Protein Alignment MUSK and F09G2.1

DIOPT Version :9

• Sequence 1: XP_005252051.1
• Gene: MUSK / 4593
• HGNCID: 7525
• Length: 879
• Species: Homo sapiens
• Sequence 2: NP_001343836.1
• Gene: F09G2.1 / 179108
• WormBaseID: WBGene00017310
• Length: 994
• Species: Caenorhabditis elegans
• Alignment Length: 1004
• Identity: 204/1004 - (20%)
• Similarity: 369/1004 - (36%)
• Gaps: 306/1004 - (30%)

Human     9 LVHILTL--------VAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYP-------QPE 58
            |:|:.|:        .|..|.:    .|:||.|            .:||...::.       |..
 Worm    12 LLHLCTVSLVLCDQFCATDGND----TPIITDP------------NYMCNDANFTNLRNPPLQNS 60

Human    59 ISWTRNKILIKL--FDTRYSIREN-GQLLTILSVEDSDDGIYCCTANNGVGGAVES--------- 111
            .|:|.|..::.|  .|:.::..|| .|::..:|  |:.|   .| ...|||.||.:
 Worm    61 SSYTNNCDVVFLLDLDSTFTTEENYTQVIQFIS--DATD---TC-MKRGVGYAVFAFPMFNDTHE 119

Human   112 ---CGALQVK--------------------MKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVS 153
               |...|.|                    ::|...:...:..:|..||.|      |:|:.:..
 Worm   120 TVCCSPSQCKTAFGFMNYRDYVGKYDDMEPVQPSTNQYNFSFVLINDLKRV------GSPQSACL 178

Human   154 WIKGDSPLRENSRIAVLESGSLRIHN------VQKEDAGQYR--CVAKNSLGTAYSKVVKLEVEE 210
            :         |:.:.:..    |:.|      |..|.|...|  |:....:....|::
 Worm   179 Y---------NNYVLITN----RLFNITDQTLVLAEIAKILRTGCITFTIIAVGNSEI------- 223

Human   211 ESEPEQDTKVFARILRAPESHNVTFGSF-----------------------VTLH-C-------- 243
                  |||:...:.:....:.....||                       |||. |
 Worm   224 ------DTKMMYDVYKTVTLNTYVVQSFNCLDILKDCIKPCGTGGSQQCYDVTLDVCATPTTAEP 282

Human   244 ----TATGIPVPT----------ITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIA 294
                |:|..|.||          ||::   .|:::.:.||..      |||..:|:.| |..|
 Worm   283 TTTVTSTSTPKPTLDPEYLNDWQITYL---FAITNRTSQEQF------SRLVKYISDP-LEDC-- 335

Human   295 TNKHGEKFSTAKAAATISIAEWSKPQKDNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPEEAQE 359
                     :.||    .|..:......|.|:                        .:|.::...
 Worm   336 ---------SGKA----MIIRFLARNNSNSGW------------------------ISDVDQVAP 363

Human   360 LLVHTAWNELKVVSP--VCRPAAEALLCNHIFQECS-------PGVVPTP-IPICREYCLAVKEL 414
            .|...:::|:.:.|.  ...|..:.:..:.:::..|       .|.|..| :.:..::   |..:
 Worm   364 YLQQLSYDEVLIASDNRTLLPGNDNVTFDLVWEAVSTSPCYNEDGTVHVPKVVLLTDF---VSNV 425

Human   415 FCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLPSMHWDPTACARLPHLDY----NKENLKTFPP 475
            |.|:             |.:.:          ||.:.:...:........|    :|..:|.| .
 Worm   426 FVAQ-------------YNTTL----------LPLLEFYEFSIIAFTEEAYDGYKSKLAMKAF-Q 466

Human   476 MTSSKPSVDIPNL---PSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNK 537
            :|:.:...|...|   |...|:..::     |.:||...|. |:.:|:.:|.||  |::..|..|
 Worm   467 ITNDEGYGDTNELKLCPKQGSNVTTI-----MFIIIGTCSG-AMLILILLTVLY--RQKYMWMRK 523

Human   538 KRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQA 602
            .:......:..:....:.|  |....:.:: ::.|.||                |.||:|.||:.
 Worm   524 LKRFKTSHVADIDDNDIFD--HWELSWDKL-VVKNEKL----------------GHGAYGHVFKG 569

Human   603 RAPGLLP-YEPFTMV----------AVKMLKEEASADMQADFQREAALMAEFD-NPNIVKLLGVC 655
            :..|:.| .|.:...          |||||.:.|:...:.:|:.|..||.... |.::|.:||..
 Worm   570 KIVGVPPAIEKYNRAEALDYTDCDCAVKMLPKYATDAAKQEFRHEIELMKNLGFNEHLVNMLGCI 634

Human   656 AVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVA 720
            .|....||:.|:..:.||..::::..    |     ||.:...|.....   |..|.|..|.|:.
 Worm   635 TVSAKSCLVLEHCCHRDLLRYVKNKK----C-----DLEISRSVDDTID---SHKEFLNFAWQIT 687

Human   721 AGMAYLSERKFVHRDLATRNCLVGEN---MVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPE 782
            .||.:|.:::.:|||||.||.|:.|.   ...|::||||:.....::..:...:|.:||:|:..|
 Worm   688 QGMRFLVDKRIIHRDLAARNILITEQCGMKSAKVSDFGLAILSEPSENGEVTGSDRLPIKWLALE 752

Human   783 SIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRL 847
            .:....::.:||||::|:|::|::|.|..|:..:...|:|.:::.|.....|.....::..:|..
 Worm   753 CLEKAEFSFKSDVWSFGIVIFEMYSLGDVPFAEIEPTELIAHLKSGARPKFPLLATDKIEEIMSS 817

Human   848 CWSKLPADRPSFTSIHRILERMCER-AEG 875
            |||:...:||.|..:.::.....|: .||
 Worm   818 CWSEKSEERPDFDELSKLFATQLEQTTEG 846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MUSK	XP_005252051.1	I-set	28..117	CDD:254352	25/110 (23%)
		Ig	36..117	CDD:299845	21/102 (21%)
		I-set	121..203	CDD:254352	16/89 (18%)
		Ig	135..201	CDD:299845	13/73 (18%)
		I-set	223..306	CDD:254352	23/128 (18%)
		Ig	239..306	CDD:143165	21/89 (24%)
		CRD_FZ	325..467	CDD:295308	17/155 (11%)
		PTKc_Musk	579..868	CDD:133181	81/303 (27%)
		Pkinase_Tyr	585..866	CDD:285015	81/295 (27%)
F09G2.1	NP_001343836.1	PTKc	556..837	CDD:270623	83/308 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910