DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MUSK and kin-15

DIOPT Version :9

Sequence 1:	XP_005252051.1	Gene:	MUSK / 4593	HGNCID:	7525	Length:	879	Species:	Homo sapiens
Sequence 2:	NP_741035.2	Gene:	kin-15 / 174498	WormBaseID:	WBGene00002199	Length:	488	Species:	Caenorhabditis elegans

Alignment Length:	465	Identity:	126/465 - (27%)
Similarity:	204/465 - (43%)	Gaps:	86/465 - (18%)

- Green bases have known domain annotations that are detailed below.

Human   460 LPHLDYNKENLKTFPPMTSSKPSVDIPNLPSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITT 524
            |.||.|:....::|         .:.|::.|..|:...:...:.:.::|.|:      ::|....
Worm    18 LMHLVYSNSTFESF---------TENPHISSQISNVLYMDQMFIIYILICIL------LILISVI 67

Human   525 LYCCRRRKQWK-------NKKRESAAV----TLTTLPSELLLDRLHPN---PMYQRMPLLLNPKL 575
            :|..:|..|..       ..:|.:..|    .:..||.  |||....|   |:.:|.   :|.::
Worm    68 VYLSKRYSQQMMQSSDNITNRRSNPEVRNKSNIYDLPP--LLDVTSVNEETPIVKRP---INERI 127

Human   576 LSLEY-PRNNIEYVR------DIGEGAFGRVFQARAPGLLPY-----EPFTM----VAVKMLKEE 624
            .:||: ||..|:..:      .:|.|.||.|    ..|||..     |..|:    ||||...:.
Worm   128 ENLEFDPRFEIDQAKLEISEDKLGSGFFGEV----CYGLLSMRTSNTETDTLQKLSVAVKQSNDP 188

Human   625 ASADMQADFQREAALMAEFD-NPNIVKLLGVCAVGKPMC---LLFEYMAYGDLNEFL-------- 677
            ...:.:...:.|..||.... ||||:.::|.........   |:.|::..|||.:||
Worm   189 TQENQEKMIEDETKLMCAIGRNPNILAIIGAVTANSGSARNLLIVEFVECGDLLKFLEEKKSIFK 253

Human   678 -------------RSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSER 729
                         :|:...|.....:.|..:...:.|     |..::.|..:.|:|.||.||:..
Worm   254 DELVYEKNGYLLPKSIRRKTYMFNENEDDVIEESLDS-----LCTSDLLSFSYQIAEGMEYLASI 313

Human   730 KFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANE--NDAIPIRWMPPESIFYNRYTTE 792
            ..||||||.||.|:.:|..::||||||:|......||:..:  ...:|.|||.||.:...:.|.:
Worm   314 PCVHRDLALRNVLLNKNKTIRIADFGLARKYQVDGYYRITKGVGTPMPARWMAPEVMREGKCTEK 378

Human   793 SDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRP 857
            ||||:|||.|:|:||.|..||..:::.:|..:|..||.|..|:.|..::|:.|:..|:.....||
Worm   379 SDVWSYGVSLYEMFSLGELPYSNVSNSDVFEHVVQGNQLPMPQYCHPKMYDRMKQFWNFDATFRP 443

Human   858 SFTSIHRILE 867
            ||:......|
Worm   444 SFSKCVEFFE 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MUSK	XP_005252051.1	I-set	28..117	CDD:254352
		Ig	36..117	CDD:299845
		I-set	121..203	CDD:254352
		Ig	135..201	CDD:299845
		I-set	223..306	CDD:254352
		Ig	239..306	CDD:143165
		CRD_FZ	325..467	CDD:295308	4/6 (67%)
		PTKc_Musk	579..868	CDD:133181	100/332 (30%)
		Pkinase_Tyr	585..866	CDD:285015	96/322 (30%)
kin-15	NP_741035.2	STYKc	147..452	CDD:214568	95/313 (30%)
kin-15	NP_741035.2	PTKc	148..453	CDD:270623	95/313 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910