DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shi and MGM1

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_014854.2	Gene:	MGM1 / 854386	SGDID:	S000005737	Length:	881	Species:	Saccharomyces cerevisiae

Alignment Length:	758	Identity:	184/758 - (24%)
Similarity:	322/758 - (42%)	Gaps:	197/758 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 65
            |..:.||:||:.    |...|  |.||.|.|:|.||:|||||||:.||::|||:||.:|||||:.
Yeast   191 MIEIRTILNKVD----SSSAH--LTLPSIVVIGSQSSGKSSVLESIVGREFLPKGSNMVTRRPIE 249

  Fly    66 LQLI-----NGVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVL 125
            |.|:     |.||  .:|..::......|.|:::.:. |.:....:::.:|..||.|.:.|..|.
Yeast   250 LTLVNTPNSNNVT--ADFPSMRLYNIKDFKEVKRMLM-ELNMAVPTSEAVSEEPIQLTIKSSRVP 311

  Fly   126 NLTLIDLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDP 190
            :|:|:||||..:|...|||::::.:|:.:..:::.... :|||::.|:.|||||.|||.:|..||
Yeast   312 DLSLVDLPGYIQVEAADQPIELKTKIRDLCEKYLTAPN-IILAISAADVDLANSSALKASKAADP 375

  Fly   191 QGVRTIGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRS---------------------- 233
            :|:|||||||||||:|. ..||.||.||..||..||:||:.::
Yeast   376 KGLRTIGVITKLDLVDP-EKARSILNNKKYPLSMGYVGVITKTPSSINRKHLGLFGEAPSSSLSG 439

  Fly   234 ------------QKDIEGRKDI--HQALAAERKFFLSHPSY--------RHMADRLGTPYLQRVL 276
                        :::..|.|.|  ||   .|:.:|..:..|        :.:.::     |.::|
Yeast   440 IFSKGQHGQSSGEENTNGLKQIVSHQ---FEKAYFKENKKYFTNCQVSTKKLREK-----LIKIL 496

  Fly   277 NQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKAMLQM-IQQLQSDFERTIE 340
            ...::|.:..|...::.:|.......:.|..: :|..|....:....:|:: |::.|..|.|
Yeast   497 EISMSNALEPTSTLIQQELDDTSYLFKVEFND-RHLTPKSYLLNNIDVLKLGIKEFQEKFHR--- 557

  Fly   341 GSGSALVNTNELSGGAKINRIFHERLRFEIVKMACDEKEL------------------------- 380
                     |||.               .|::...|:|.|
Yeast   558 ---------NELK---------------SILRAELDQKVLDVLATRYWKDDNLQDLSSSKLESDT 598

  Fly   381 -----RREISFAIRNIHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELS-VVVRMCT 439
                 .:::..|...:..:.:|..:..:...||:|....:|:...:|..:|:...:| ..:.:..
Yeast   599 DMLYWHKKLELASSGLTKMGIGRLSTMLTTNAILKELDNILESTQLKNHELIKDLVSNTAINVLN 663

  Fly   440 AKMSRYPRLREETERII-----TTHVRQREHS-CKEQILLLIDFELAYMNTNHEDFIGFANAQNK 498
               |:|....::.|..|     ...:.:|:.| .::..:.||..||...|:.::..
Yeast   664 ---SKYYSTADQVENCIKPFKYEIDLEERDWSLARQHSINLIKEELRQCNSRYQAI--------- 716

  Fly   499 SENANKTGTRQLGNQVIRKGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLTSESI 563
               .|..|:::|.|.:   |:  ::|...::...||.|..|..|       ||...:.....:.:
Yeast   717 ---KNAVGSKKLANVM---GY--LENESNLQKETLGMSKLLLER-------GSEAIFLDKRCKVL 766

  Fly   564 SW-------------YKD----------EDEKEKKFMLPLDGLKLRDIEQGF-MSMSRRVT---- 600
            |:             .||          .|:.....:|.|:...|.|....| :.:.||:|
Yeast   767 SFRLKMLKNKCHSTIEKDRCPEVFLSAVSDKLTSTAVLFLNVELLSDFFYNFPIELDRRLTLLGD 831

  Fly   601 -----FALFSPD-GRNV--YKDYKQLELSCETVEDVESWKASF 635
                 ||...|. .|::  .|..:.|||:.|.::.:..:|.|:
Yeast   832 EQVEMFAKEDPKISRHIELQKRKELLELALEKIDSILVFKKSY 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	100/277 (36%)
		CrfC	73..>498	CDD:223771	110/506 (22%)
		Dynamin_M	212..498	CDD:279383	59/367 (16%)
		PH_dynamin	512..644	CDD:269958	33/160 (21%)
		PH	552..638	CDD:278594	23/120 (19%)
		GED	664..755	CDD:128597
		DUF4527	<758..819	CDD:291689
		Drf_FH1	<761..>846	CDD:283903
MGM1	NP_014854.2	CrfC	93..826	CDD:223771	171/708 (24%)
MGM1	NP_014854.2	DLP_1	208..468	CDD:206738	98/267 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870