DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shi and VPS1

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_012926.1	Gene:	VPS1 / 853870	SGDID:	S000001709	Length:	704	Species:	Saccharomyces cerevisiae

Alignment Length:	806	Identity:	311/806 - (38%)
Similarity:	415/806 - (51%)	Gaps:	156/806 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DSLITIVNKLQDAFTSLGVHMQ--LDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPL 64
            :.||:.:||||||...||...|  :|||||.|||.||:||||||||.||:||||||:||||||||
Yeast     3 EHLISTINKLQDALAPLGGGSQSPIDLPQITVVGSQSSGKSSVLENIVGRDFLPRGTGIVTRRPL 67

  Fly    65 ILQLIN--------------------------------------------GVTEYGEFLHIKGKK 85
            :|||||                                            ...|:|||||:.|||
Yeast    68 VLQLINRRPKKSEHAKVNQTANELIDLNINDDDKKKDESGKHQNEGQSEDNKEEWGEFLHLPGKK 132

  Fly    86 FSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLIDLPGLTKVAIGDQPVDIEQQ 150
            |.:||||||||..|||:|||:|.|||::|||||:||||||.|||:||||||||.:||||.|||:|
Yeast   133 FYNFDEIRKEIVKETDKVTGANSGISSVPINLRIYSPHVLTLTLVDLPGLTKVPVGDQPPDIERQ 197

  Fly   151 IKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRTIGVITKLDLMDEGTDARDIL 215
            ||.|:.::|.|...:||:|..|||||||||.||||:||||:|.|||||:||:||||:|||..|||
Yeast   198 IKDMLLKYISKPNAIILSVNAANTDLANSDGLKLAREVDPEGTRTIGVLTKVDLMDQGTDVIDIL 262

  Fly   216 ENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSYRHMADRLGTPYLQRVLNQQL 280
            ..:::|||.|||.|:||.|||||.:|.|.:||..|||||.:||||...|...|||||.:.||..|
Yeast   263 AGRVIPLRYGYIPVINRGQKDIEHKKTIREALENERKFFENHPSYSSKAHYCGTPYLAKKLNSIL 327

  Fly   281 TNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKAMLQMIQQLQSDFERTIEGSGSA 345
            .:|||.|||.::.|::   .||:|...|..:..|......:..:|.||....:::...::|....
Yeast   328 LHHIRQTLPEIKAKIE---ATLKKYQNELINLGPETMDSASSVVLSMITDFSNEYAGILDGEAKE 389

  Fly   346 LVNTNELSGGAKINRIFHERLRFEIVKMACDEKELRREISFAIRNIHGIRVGLFTPDMAFEAIVK 410
            | ::.||||||:|:.:|||..:..:..:...::....:|...:.|..|....||....|||.:||
Yeast   390 L-SSQELSGGARISYVFHETFKNGVDSLDPFDQIKDSDIRTIMYNSSGSAPSLFVGTEAFEVLVK 453

  Fly   411 RQIALLKEPVIKCVDLVVQELSVVVRM-----CTAKMSRYPRLREETERIITTHVRQREHSCKEQ 470
            :||...:||.::.|.||..||   |||     ...|.||||.|||.........::.......|.
Yeast   454 QQIRRFEEPSLRLVTLVFDEL---VRMLKQIISQPKYSRYPALREAISNQFIQFLKDATIPTNEF 515

  Fly   471 ILLLIDFELAYMNTNHEDFIGFANAQNKSENANKTGTRQLGNQVIRKGHMVIQNLGIMKDIKLGR 535
            ::.:|..|..|:||.|.|.:                          ||...:    :|.:.||
Yeast   516 VVDIIKAEQTYINTAHPDLL--------------------------KGSQAM----VMVEEKL-- 548

  Fly   536 SGPLNVRFFSPSTGGSRPYWFVLTSESISWYKDEDEKEKKFMLPLDGLKLRDIEQGFMS-MSRRV 599
             .|..|. ..|.||...|     |..|.|.....:||...|             .||.| .:::.
Yeast   549 -HPRQVA-VDPKTGKPLP-----TQPSSSKAPVMEEKSGFF-------------GGFFSTKNKKK 593

  Fly   600 TFALFSPDGRNVYKDYKQLELSCETVEDVESWKASFLRAGVYPEKQETQENGDESASEESSSDPQ 664
            ..||.||                          ...|:|.....::||.|
Yeast   594 LAALESP--------------------------PPVLKATGQMTERETME--------------- 617

  Fly   665 LERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLIINNAKDFINGELLAHLYASGDQAQMMEESA 729
                .|.|:.|:.||..||.:|..|::|||:|:.:|..:|..|...||..||...|..::.:|:.
Yeast   618 ----TEVIKLLISSYFSIVKRTIADIIPKALMLKLIVKSKTDIQKVLLEKLYGKQDIEELTKEND 678

  Fly   730 ESATRREEMLRMYRACKDALQIIGDV 755
            .:..||:|..:|....::|.||:..|
Yeast   679 ITIQRRKECKKMVEILRNASQIVSSV 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	165/283 (58%)
		CrfC	73..>498	CDD:223771	202/429 (47%)
		Dynamin_M	212..498	CDD:279383	104/290 (36%)
		PH_dynamin	512..644	CDD:269958	26/132 (20%)
		PH	552..638	CDD:278594	15/86 (17%)
		GED	664..755	CDD:128597	29/90 (32%)
		DUF4527	<758..819	CDD:291689
		Drf_FH1	<761..>846	CDD:283903
VPS1	NP_012926.1	DLP_1	27..336	CDD:206738	180/308 (58%)
		Dynamin_M	258..541	CDD:395818	106/315 (34%)
		GED	616..704	CDD:396682	30/106 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	240	1.000	Domainoid score	I373
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X876
TreeFam	0	0.000	Not matched by this tool.
	6	5.810