DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shi and FZO1

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_009738.1	Gene:	FZO1 / 852477	SGDID:	S000000383	Length:	855	Species:	Saccharomyces cerevisiae

Alignment Length:	547	Identity:	102/547 - (18%)
Similarity:	198/547 - (36%)	Gaps:	154/547 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 DTLPGLRDKLQKQMLTLEKEVEEFKHFQP----GDASIKTKAMLQMIQQ--------LQSDFER- 337
            |.||.||....|..| :..::.::.:...    ..:.:||:|.:..:|:        :.::.||
Yeast    68 DLLPSLRSSNSKAHL-ISSQLSQWNYNNNRVLLKRSILKTQAFMDQLQEENNIRPIFIAANDERE 131

  Fly   338 -------TIEGSGSALVNTNELSG----GAKINRIFHERLRFEIVKMACDEKELRREISFAIRNI 391
                   .|:..|.  .||.|.:|    ...::::||.    :||.:......|::.:......:
Yeast   132 KLHVLQLNIKLDGQ--YNTKEKNGFNIEKKALSKLFHS----QIVSVTNHLNALKKRVDDVSSKV 190

  Fly   392 HGIRVGLFTPDM------AFEAIVKRQIALLKEPVIKCVD-----LVVQELSVVVRMCTAKMSRY 445
                  ..|.|:      ...:::|::  ||.|..:.|.:     |..:|...:..:....::..
Yeast   191 ------FITGDVNTGKSALCNSLLKQR--LLPEDQLPCTNVFSEILEARENDGIEEVHAIPLNIA 247

  Fly   446 PRLREETERIITTHVRQRE-HSCKEQILLLIDFELAYMNTNH---EDFIGFANAQNKSENANKTG 506
            |.|:|..:.....:.:..| |:.||    |.|  |...|..:   :.:|             |..
Yeast   248 PTLKEAIDMYSIQNPKTYEIHTLKE----LPD--LVPQNGKYALLKIYI-------------KDD 293

  Fly   507 TRQLGNQVIRKGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRP-----YWFVLTSESISWY 566
            .|.....::|.|.:         ||.|..|..||:.....:...||.     ..||:.:|:
Yeast   294 KRPASTSLLRNGTV---------DISLIDSPGLNMDSLQTAEVMSRQEEIDLVIFVVNAEN---- 345

  Fly   567 KDEDEKEKKFMLPLDGLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKDYKQL-------ELSCET 624
                      .|.|..       :.|:|::.|....:|.     |.|.:.::       ||..:.
Yeast   346 ----------QLTLSA-------KEFISLASREKKLMFF-----VVKKFDKIRDKQRCKELILKQ 388

  Fly   625 VEDV--ESWK--ASFL--------RAGVYPEKQETQENGDESASEE----SSSDPQLERQVETIR 673
            :.|:  |::|  |.|:        ....|..:.:.:::||....::    |..||..:...:::|
Yeast   389 IRDLSPETYKRAADFVHFVSKNGDELPHYHNENDNEDHGDRKPDDDPYSSSDPDPDFDSLEDSLR 453

  Fly   674 NLV---DSYMKIV-TKTTRDMVPKAIMMLIINNAKDFINGELLAHLYASGDQAQMMEESAESATR 734
            |.|   .|..|:: .||....:...|:|:..:|.|.:...|:            .:.|..|  |.
Yeast   454 NFVLKKRSLSKLLPAKTYLSKLLSDIIMISKSNMKMYSEEEI------------KINEQLE--TL 504

  Fly   735 REEMLRMYRACKDALQIIGDVSMATVS 761
            |.|:|.....|.|....:..::..|::
Yeast   505 RPEILSARAKCNDLTTSVDQMAEQTIT 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491
		CrfC	73..>498	CDD:223771	45/250 (18%)
		Dynamin_M	212..498	CDD:279383	45/250 (18%)
		PH_dynamin	512..644	CDD:269958	29/155 (19%)
		PH	552..638	CDD:278594	19/109 (17%)
		GED	664..755	CDD:128597	20/94 (21%)
		DUF4527	<758..819	CDD:291689	1/4 (25%)
		Drf_FH1	<761..>846	CDD:283903	0/1 (0%)
FZO1	NP_009738.1	CrfC	128..841	CDD:223771	91/486 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900