DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shi and DL3

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_176170.1	Gene:	DL3 / 842251	AraportID:	AT1G59610	Length:	920	Species:	Arabidopsis thaliana

Alignment Length:	938	Identity:	209/938 - (22%)
Similarity:	368/938 - (39%)	Gaps:	215/938 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 IAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLILQLI--NGVTEYGEFLHIKGKKFS-SFD 90
            :..:|...||||:||.:.:|...||.|....||.|:|:.|.  ..::.....|.|..|... |..
plant    41 VVALGNVGAGKSAVLNSLIGHPVLPTGENGATRAPIIIDLSREESLSSKAIILQIDNKNQQVSAS 105

  Fly    91 EIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLIDLPGLTKVAIGDQPVDIEQQIKQMI 155
            .:|..::|...: ..|.:|...|.:.||..:...|.  |||||||.:..:.|          .||
plant   106 ALRHSLQDRLSK-GASGRGRDEIYLKLRTSTAPPLK--LIDLPGLDQRIVDD----------SMI 157

  Fly   156 FQFIRKETCLILAVTPAN--TDLANSDALKLAKEVDPQGVRTIGVITKLDLMDEGTDA----RDI 214
            .:..:....::|.|.||:  :::::|.|||:|||.||:..||:|:|:|:|...|...:    :.:
plant   158 GEHAQHNDAILLVVVPASQASEISSSRALKIAKEYDPESTRTVGIISKIDQAAENPKSLAAVQAL 222

  Fly   215 LENKLLPLRRG--YIGVVNRSQKDIEGR-----KDIHQALAAE----RKFFLSHPSYRHMADRLG 268
            |.|:..|....  ::.::.:|......:     ..:..|..||    :......|.     .:||
plant   223 LSNQGPPKTTDIPWVALIGQSVSIASAQSGGSENSLETAWRAESESLKSILTGAPQ-----SKLG 282

  Fly   269 TPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIK----TKAM-LQMI 328
            ...|...|..|:.:.::..||.:...||.:...::.|:...     |:..:.    |:|: |::.
plant   283 RIALVDTLASQIRSRMKLRLPNILTGLQGKSQIVQDELARL-----GEQLVSSAEGTRAIALELC 342

  Fly   329 QQLQSDFERTI---EGSGSALVNTNELSGGAKINRIFHERLRFEIVKMACDEKELRREISFAIRN 390
            ::.:..|...:   ||||..:|.:.|   |...|||                |:|..:..|.:.|
plant   343 REFEDKFLLHLAGGEGSGWKVVASFE---GNFPNRI----------------KKLPLDRHFDLNN 388

  Fly   391 I-------HGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVRM---CTAKMSRY 445
            :       .|.:..|.:|:....:::|..:.|.|:|...|||.|.:.|..:|..   .|..:.||
plant   389 VKRIVLEADGYQPYLISPEKGLRSLIKTVLELAKDPARLCVDEVHRVLVDIVSASANATPGLGRY 453

  Fly   446 PRLREETERIITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIGFANAQNKSENANKTGTRQL 510
            |..:.|...|.:..:...::..|:.::.|:|.|.|::...|  ||..  .|.:.|...:  ..:|
plant   454 PPFKREVVAIASAALDGFKNEAKKMVVALVDMERAFVPPQH--FIRL--VQRRMERQRR--EEEL 512

  Fly   511 GNQVIRKGHMVIQNL----------------GIMKDIK------------------------LGR 535
            ..:..:||....|:|                |.:|.::                        .|.
plant   513 KGRSSKKGQDAEQSLLNRATSPQPDGPSSTGGSLKSLRDKLMPQDKDKDKEKETPEVSGLKTAGP 577

  Fly   536 SGPLNVRFF---SPSTGGSRPYWFVLTSES--ISWYKDEDEKEKKFMLPLDGLKLRDI--EQGFM 593
            .|.:...:.   |..|.|....||||..::  :.:.|.::|:..:..:.|:...:.:|  ::|..
plant   578 EGEITAGYLMKKSAKTNGWSRRWFVLNEKTGKLGYTKKQEERNFRGTVTLEECSIEEISDDEGEK 642

  Fly   594 SMSRRVTFALFSPDG---------------RNVYKDYKQLELSCETVEDVESWKASFLRAGVYPE 643
            |.|.:...: ..||.               :.|.|.:..|.|..|::.|...|        :...
plant   643 SKSSKDKKS-NGPDSKGPGLVFKITCRVPYKTVLKAHNALVLKAESMVDKNEW--------INKL 698

  Fly   644 KQETQENGDE--SAS-----EESSSDPQLERQVETIRNL------VDSYMKIVTKTTRDMVPKAI 695
            ::..|..|.:  |||     .|.|.|..:.:.|:....|      |..|::.|..:....||||:
plant   699 QKVIQARGGQVGSASMRQSLSEGSLDKMVRKPVDPEEELRWMSQEVRGYVEAVLNSLAANVPKAV 763

  Fly   696 MMLIINNAKDFINGELLAHLYAS-----GDQAQMMEESAESATRREEMLRMYRACKDAL--QI-I 752
            ::..:..:|:    ::|..||:|     .::.:.:.:..::..||.:..:...:....|  |: |
plant   764 VLCQVEKSKE----DMLNQLYSSISAIGNERIESLIQEDQNVKRRRDRYQKQSSLLSKLTRQLSI 824

  Fly   753 GDVSMATVSS------PLPPPVKN------DWL------PSGLDNPRLSPPSPGGVRGKPGPPAQ 799
            .|...|..||      ....|..|      ||:      .||.|:  |.....||...:...|||
plant   825 HDNRAAAASSWSDNSGTESSPRTNGGSSGEDWMNAFNAAASGPDS--LKRYGSGGHSRRYSDPAQ 887

  Fly   800 -----SSLGG--------RNPPLPPSTG 814
                 |..||        |.||.||.:|
plant   888 NGEDSSGSGGSSRRTTPNRLPPAPPQSG 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	62/221 (28%)
		CrfC	73..>498	CDD:223771	107/460 (23%)
		Dynamin_M	212..498	CDD:279383	65/314 (21%)
		PH_dynamin	512..644	CDD:269958	31/193 (16%)
		PH	552..638	CDD:278594	20/104 (19%)
		GED	664..755	CDD:128597	19/104 (18%)
		DUF4527	<758..819	CDD:291689	25/88 (28%)
		Drf_FH1	<761..>846	CDD:283903	24/85 (28%)
DL3	NP_176170.1	DLP_1	41..303	CDD:206738	71/279 (25%)
		Dynamin_M	<371..490	CDD:366427	31/134 (23%)
		PH	584..703	CDD:214574	23/127 (18%)
		GED	744..817	CDD:383023	14/76 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870