DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shi and DL1E

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_567094.1	Gene:	DL1E / 825189	AraportID:	AT3G60190	Length:	624	Species:	Arabidopsis thaliana

Alignment Length:	778	Identity:	237/778 - (30%)
Similarity:	362/778 - (46%)	Gaps:	187/778 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSLITIVNKLQDAFTSLGVH-----------MQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPR 54
            |:|||.:||::|.|.|.||.:           :...||.:|||||||:|||||||:.||:|||||
plant     4 MESLIGLVNRIQRACTVLGDYGGGTGSNAFNSLWEALPTVAVVGGQSSGKSSVLESIVGRDFLPR 68

  Fly    55 GSGIVTRRPLILQL---INGVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPIN 116
            ||||||||||:|||   .:|..||.||||:..|:|:.|..:|:||:|||||:||.||.||.:||:
plant    69 GSGIVTRRPLVLQLHKTDDGTEEYAEFLHLPKKQFTDFALVRREIQDETDRITGKNKQISPVPIH 133

  Fly   117 LRVYSPHVLNLTLIDLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDA 181
            |.:|||:|:||||||||||||||:..||..|.:.|:.|:..::.|..|:|||::|||.|:|.|||
plant   134 LSIYSPNVVNLTLIDLPGLTKVAVEGQPETIAEDIESMVRTYVDKPNCIILAISPANQDIATSDA 198

  Fly   182 LKLAKEVDPQGVRTIGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQA 246
            :||||:|||.|.||.||:|||||||:||:|.::||.:...|:..::|:|||||.||....|:..|
plant   199 IKLAKDVDPTGERTFGVLTKLDLMDKGTNALEVLEGRSYRLQHPWVGIVNRSQADINKNVDMMLA 263

  Fly   247 LAAERKFFLSHPSYRHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKH 311
            ...||::|.:.|.|.|:|.::|:.||.::|::.|.:.||..:|.:...:.|.:..||:|::....
plant   264 RRKEREYFDTSPDYGHLASKMGSEYLAKLLSKHLESVIRTRIPSILSLINKSIEELERELDRMGR 328

  Fly   312 FQPGDASIKTKAMLQMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVKMACD 376
            ....||..:...:|:|.:.....|:..::|.         ..||.:|..:|..:|...:.|:..|
plant   329 PVAVDAGAQLYTILEMCRAFDKIFKEHLDGG---------RPGGDRIYGVFDNQLPAALKKLPFD 384

  Fly   377 EKELRREISFAIRNIHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVRMC--- 438
            .....:.:...:....|.:..|..|:..:..:::..:...:.|....||.|...|..:||..
plant   385 RHLSLQSVKKIVSEADGYQPHLIAPEQGYRRLIEGALGYFRGPAEASVDAVHYVLKELVRKSISE 449

  Fly   439 TAKMSRYPRLREETERIITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIGFANAQNKSENAN 503
            |.::.|:|.|:.|......:.:.:.....|:.::.|:|.|.||
plant   450 TEELKRFPSLQVELAAAANSSLEKFREESKKSVIRLVDMESAY---------------------- 492

  Fly   504 KTGTRQLGNQVIRKGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLTSESISWYKD 568
                                               |...||.
plant   493 -----------------------------------LTAEFFR----------------------- 499

  Fly   569 EDEKEKKFMLPLDGLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKDYKQLELSCETVEDVESWKA 633
                    .||      ::||       |.||
plant   500 --------KLP------QEIE-------RPVT--------------------------------- 510

  Fly   634 SFLRAGVYPEKQETQENGDESASEESSSDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMML 698
                      ..:.|.....||:.:...|....|    |.:.|.:|:.:|:.|.|:.:|||.:..
plant   511 ----------NSKNQTASPSSATLDQYGDGHFRR----IASNVSAYVNMVSDTLRNTIPKACVYC 561

  Fly   699 IINNAKDFINGELLAHLYA-----SGDQ-AQMMEESAESATRREE---MLRMYRACKDALQII 752
            .:..||    ..||.:.|:     .|.| .|:::|......||.|   .|.:|:..:|.:..:
plant   562 QVRQAK----LALLNYFYSQISKREGKQLGQLLDEDPALMDRRLECAKRLELYKKARDEIDAV 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	143/252 (57%)
		CrfC	73..>498	CDD:223771	150/427 (35%)
		Dynamin_M	212..498	CDD:279383	66/288 (23%)
		PH_dynamin	512..644	CDD:269958	10/131 (8%)
		PH	552..638	CDD:278594	7/85 (8%)
		GED	664..755	CDD:128597	25/98 (26%)
		DUF4527	<758..819	CDD:291689
		Drf_FH1	<761..>846	CDD:283903
DL1E	NP_567094.1	DLP_1	40..306	CDD:206738	148/265 (56%)
		Dynamin_M	228..493	CDD:395818	67/330 (20%)
		GED	531..620	CDD:396682	25/96 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	234	1.000	Domainoid score	I626
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264244at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820