DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shi and DRP3B

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_001154516.1	Gene:	DRP3B / 815898	AraportID:	AT2G14120	Length:	809	Species:	Arabidopsis thaliana

Alignment Length:	819	Identity:	295/819 - (36%)
Similarity:	429/819 - (52%)	Gaps:	123/819 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLILQ 67
            |:|.|||||||.|..||....:.|||:||||.||:|||||||..||:||||||:.|.|||||.||
plant    20 SVIPIVNKLQDIFAQLGSQSTIALPQVAVVGSQSSGKSSVLEALVGRDFLPRGNDICTRRPLRLQ 84

  Fly    68 LI--------NGVTEYGEFLHIKG-KKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPH 123
            |:        ....|:|||||... ::...|.|||:|||.||:||:|.|||:|:|||.|:::||:
plant    85 LVQTKPSSDGGSDEEWGEFLHHDPVRRIYDFSEIRREIEAETNRVSGENKGVSDIPIGLKIFSPN 149

  Fly   124 VLNLTLIDLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEV 188
            ||:::|:||||:|||.:||||.|||.:|:.||..:|::.:||||||:||||||||||||::|...
plant   150 VLDISLVDLPGITKVPVGDQPSDIEARIRTMILTYIKEPSCLILAVSPANTDLANSDALQIAGNA 214

  Fly   189 DPQGVRTIGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKF 253
            ||.|.||||||||||:||.|||||:.|..|.:|||.||:|||||||:||...:.|..||.||.||
plant   215 DPDGHRTIGVITKLDIMDRGTDARNHLLGKTIPLRLGYVGVVNRSQEDILMNRSIKDALVAEEKF 279

  Fly   254 FLSHPSYRHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDAS 318
            |.|.|.|..:.||||.|.|.:.|||.|..||:..||.|:.::...:....||.|.:     ||.:
plant   280 FRSRPVYSGLTDRLGVPQLAKKLNQVLVQHIKALLPSLKSRINNALFATAKEYESY-----GDIT 339

  Fly   319 I----KTKAMLQMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERL--RFEIVKMA--- 374
            .    :...:|..|.:....:..|:||. |..::|:||||||:|..||....  ..|::.:.
plant   340 ESRGGQGALLLSFITKYCEAYSSTLEGK-SKEMSTSELSGGARILYIFQSVFVKSLEVITVCRYL 403

  Fly   375 -------CDE----------------KELRR-EISFAIRNIHGIRVGLFTPDMAFEAIVKRQIAL 415
                   |.|                ::|.. :|..||:|..|.|..||.||:.||.:|:|||:.
plant   404 CLVSGAICTEGRQFVSGFQFLEVDPCEDLTADDIRTAIQNATGPRSALFVPDVPFEVLVRRQISR 468

  Fly   416 LKEPVIKCVDLVVQELSVVVRMCTAK-MSRYPRLREETERIITTHVRQREHSCKEQILLLIDFEL 479
            |.:|.::|...:..||..:...|..| :.|:|.|::..:.:|...:|:.....:..|..||:.|:
plant   469 LLDPSLQCARFIFDELVKISHQCMMKELQRFPVLQKRMDEVIGNFLREGLEPSQAMIRDLIEMEM 533

  Fly   480 AYMNTNHEDFIGFANAQNKSENANKTG-----------------TRQLGNQVIRKGHMVIQNLGI 527
            .|:||:|.:|||...|..::....|:.                 |...|:|:..:..:..|..||
plant   534 DYINTSHPNFIGGTKAVEQAMQTVKSSRIPHPVARPRDTVEPERTASSGSQIKTRSFLGRQANGI 598

  Fly   528 MKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLTSESISWYKDEDEKEKKFMLPLDGLKLRDIEQGF 592
            :.|    ::.|.......|:..|           |.||                        .||
plant   599 ITD----QAVPTAADAERPAPAG-----------STSW------------------------SGF 624

  Fly   593 MSMSRRVTFALFSPDGRNVYKDYKQLELSCETVEDVESWKASFLRAGVYPEKQETQENGDESASE 657
            .|:.|       ..||:...|:....:...||.::|....::     :|.::..|.....|:.||
plant   625 SSIFR-------GSDGQAAAKNNLLNKPFSETTQEVYQNLST-----IYLKEPPTILKSSETHSE 677

  Fly   658 ESSSDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLIINNAKDFINGELLAHLYASGDQA 722
            :.|.      ::|..:.|:.||..||.|...|:||||||..::|..|..::...:..||......
plant   678 QESV------EIEITKLLLKSYYDIVRKNVEDLVPKAIMHFLVNYTKRELHNVFIEKLYRENLIE 736

  Fly   723 QMMEESAESATRREEMLRMYRACKDALQIIGDVSMATVS 761
            ::::|..|.|.:|:......|..:.|.:.:.::.:...|
plant   737 ELLKEPDELAIKRKRTQETLRILQQANRTLDELPLEAES 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	149/245 (61%)
		CrfC	73..>498	CDD:223771	195/459 (42%)
		Dynamin_M	212..498	CDD:279383	108/319 (34%)
		PH_dynamin	512..644	CDD:269958	22/131 (17%)
		PH	552..638	CDD:278594	13/85 (15%)
		GED	664..755	CDD:128597	24/90 (27%)
		DUF4527	<758..819	CDD:291689	1/4 (25%)
		Drf_FH1	<761..>846	CDD:283903	1/1 (100%)
DRP3B	NP_001154516.1	DLP_1	41..315	CDD:206738	160/273 (59%)
		CrfC	98..766	CDD:223771	249/730 (34%)
		Dynamin_M	238..552	CDD:279383	108/319 (34%)
		GED	682..769	CDD:280391	24/86 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264244at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820