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Protein Alignment shi and Mfn1

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_077162.2	Gene:	Mfn1 / 67414	MGIID:	1914664	Length:	741	Species:	Mus musculus

Alignment Length:	816	Identity:	145/816 - (17%)
Similarity:	266/816 - (32%)	Gaps:	283/816 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 HMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLILQLINGVTEYGEFLHIKG-- 83
            ||     ::|..|..|:|||||:...:....||.|.|..|...|.::..:|...|   |..:|
Mouse    75 HM-----KVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKAY---LMTEGSD 131

  Fly    84 --KKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVL------NLTLIDLPGLTKVAI 140
              |...:.:::...:..:.|...|         ..:.|:.|...      :|.|:|.||
Mouse   132 EKKSVKTVNQLAHALHMDKDLKAG---------CLVHVFWPKAKCALLRDDLVLVDSPG------ 181

  Fly   141 GDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRTIGVITKLDLM 205
                .|:..::...|.:|.......:|.....:| |.|::.....|..:......|.::.  :..
Mouse   182 ----TDVTTELDIWIDKFCLDADVFVLVANSEST-LMNTEKHFFHKVNERLSKPNIFILN--NRW 239

  Fly   206 DEGTDARDILENKLLPLRRGYIGVVNRSQKD------IEGRKDIHQALAAERKFFLSHPSYRHMA 264
            |......:.:|:            |.|...:      :|..|.:..:.|..|.||:|
Mouse   240 DASASEPEYMED------------VRRQHMERCLHFLVEELKVVSPSEARNRIFFVS-------- 284

  Fly   265 DRLGTPYLQRVLNQQLTNHIRDTLP----GLRDKLQKQMLTLEKEVEEFKHFQP------GDASI 319
                   .:.|||.:  .|....:|    .|.:..|.::       :||::|:.      ..:::
Mouse   285 -------AKEVLNSR--KHKAQGMPEGGGALAEGFQARL-------QEFQNFEQTFEECISQSAV 333

  Fly   320 KTKAMLQMIQQLQ-SDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVKMACDEKELRRE 383
            |||.....|:..| .|..:.|..|    ||.     .|...|::           :.:|:|.:.:
Mouse   334 KTKFEQHTIRAKQILDTVKNILDS----VNV-----AAAEKRVY-----------SMEEREDQID 378

  Fly   384 ISFAIRNIHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQE----LSVVV--------- 435
            ....|||    ::.|.|.|      ||::|..:.|.|...|...:.:    |||:|
Mouse   379 RLDFIRN----QMNLLTLD------VKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHP 433

  Fly   436 -------------------------RMCTAK-----MSRYPRLREETERIITTHVRQREHS---C 467
                                     ..||.:     :.....:.|..:.::...::.:.|:   |
Mouse   434 TPSVLKVYKSELNKHIEDGMGRNLADRCTNEVNASILQSQQEIIENLKPLLPAGIQNKLHTLIPC 498

  Fly   468 KE----------------QILLLIDFELAYMNTNHEDFIGFANAQNKSENANKTGTRQLGNQVIR 516
            |:                |..::..|.|.:.:..|. |:|..|||.
Mouse   499 KKFDLSYDLNCHKLCSDFQEDIVFRFSLGWSSLVHR-FLGSTNAQR------------------- 543

  Fly   517 KGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLTSESISWYKDEDEKEKKFMLPLD 581
                          :.||.|.|:   |..|.:..|.|     |:.|.....|...:|:..:..:.
Mouse   544 --------------VLLGLSEPI---FQVPRSLASTP-----TAPSNPAAPDNAAQEELMITLIT 586

  Fly   582 GLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKD------------------YKQLELSCETVEDV 628
            ||         .|::.|.:..:....| .::|.                  |::|..:....|
Mouse   587 GL---------ASLTSRTSMGIIVVGG-VIWKTVGWKLISVTLSMYGALYLYERLTWTTRAKE-- 639

  Fly   629 ESWKASFLRAGVYPEKQE-----TQENGDESASEESS------------SDPQLERQVETIRNLV 676
            .::|..|:....  ||.:     |..|......:|.:            :...||.::..:...:
Mouse   640 RAFKQQFVNYAT--EKLQMIVSFTSANCSHQVQQEMATTFARLCQQVDVTQKHLEEEIARLSKEI 702

  Fly   677 DSYMKIV--TKTTRDMVPKAIMM--LIINNAKDFIN 708
            |...||.  :|..|:   ||:.:  .:.|.:|.|::
Mouse   703 DQLEKIQNNSKLLRN---KAVQLESELENFSKQFLH 735

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.