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Protein Alignment shi and Mfn2

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_570964.4	Gene:	Mfn2 / 64476	RGDID:	628843	Length:	757	Species:	Rattus norvegicus

Alignment Length:	867	Identity:	149/867 - (17%)
Similarity:	283/867 - (32%)	Gaps:	302/867 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ITIVNKLQDAFTSLGVHMQ------------------------LDLP------------------ 27
            :|...|:...|..||.::|                        ||:.
  Rat    33 VTAKKKINGIFEQLGAYIQESAGFLEDTHRNTELDPVTTEEQVLDVKGYLSKVRGISEVLARRHM 97

  Fly    28 QIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLILQLINGVTEYGEFLHIKG----KKFSS 88
            ::|..|..|.|||:|:...:....||.|.|..|.   ....:.|...:..||..:|    |...:
  Rat    98 KVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTN---CFLRVGGTDGHEAFLLTEGSEEKKSVKT 159

  Fly    89 FDEIRKEIEDETDRVTGSNKGI----SNIPINLRVYSPHVLNLTLIDLPGLTKVAIGDQPVDIEQ 149
            .:::...:..:.....||...:    |..|: |:.      :|.|:|.||          :|:..
  Rat   160 VNQLAHALHQDEQLHAGSLVSVMWPNSKCPL-LKD------DLVLMDSPG----------IDVTT 207

  Fly   150 QIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKE------VDPQGVRTIGVITKLDLMDEG 208
            ::...|.:|.......:|        :|||::..:..|      |..:..|     ..:.:::..
  Rat   208 ELDSWIDKFCLDADVFVL--------VANSESTLMQTEKQFFHKVSERLSR-----PNIFILNNR 259

  Fly   209 TDARDILENKLLPLRRGY-----------IGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSYRH 262
            .||.......:..:||.:           :|||:|:|             |.:|.||:|
  Rat   260 WDASASEPEYMEEVRRQHMERCTSFLVDELGVVDRAQ-------------AGDRIFFVS------ 305

  Fly   263 MADRLGTPYLQRVLNQQLTNHIRDTLP----GLRDKLQKQMLTLEKEVEEFKHFQP------GDA 317
                     .:.||:.::..  ...:|    .|.:..|.:|.       ||::|:.      ..:
  Rat   306 ---------AKEVLSARVQK--AQGMPEGGGALAEGFQVRMF-------EFQNFERRFEECISQS 352

  Fly   318 SIKTKAMLQMIQQLQ-SDFERTIEGSGSALVNTNELSGGAKINRIF--------HERLRF---EI 370
            ::|||.....::..| ::..|.|..|         |...|:..|::        .:||||   ::
  Rat   353 AVKTKFEQHTVRAKQIAEAVRLIMDS---------LHIAAQEQRVYCLEMREERQDRLRFIDKQL 408

  Fly   371 VKMACDEKELRREISFAIRNIHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELS--- 432
            ..:|.|.|               :|:...|.:      |:||::......|:.:.::|.|..
  Rat   409 ELLAQDYK---------------LRIKQMTEE------VERQVSTAMAEEIRRLSVLVDEYQMDF 452

  Fly   433 ----VVVRMCTAKMSRY------PRLREETERIITTHVRQREH------------SCKEQILLLI 475
                ||:::...::.|:      ..:.:.....|.:.::..:.            |.:.||.:|:
  Rat   453 HPSPVVLKVYKNELHRHIEEGLGRNMSDRCSTAIASSLQTMQQDMIDGLKPLLPVSVRNQIDMLV 517

  Fly   476 D---FELAYMNTNHEDFIGFANAQNKSENANKTGTRQLGNQVIRKGHMVIQNLGIMKDIKLGRSG 537
            .   |.|:| :.|.:...  |:.|...|.....|...|.|:.:                     |
  Rat   518 PRQCFSLSY-DLNCDKLC--ADFQEDIEFHFSLGWTMLVNRFL---------------------G 558

  Fly   538 PLNVRFFSPSTGGSRPYWFVLTSESISWYKDEDEK------EKKFMLPLDGLKLRDIE------Q 590
            |.|.|                  .::..|.|:.::      ....|.||....|...|      .
  Rat   559 PKNSR------------------RALLGYNDQVQRPLPLTPANPSMPPLPQGSLTQEELMVSMVT 605

  Fly   591 GFMSMSRRVTFALFSPDGRNVYKD------------------YKQLELSCETVEDVESWKASFLR 637
            |..|::.|.:..:....| .|:|.                  |::|..:....|  .::|..|:.
  Rat   606 GLASLTSRTSMGILVVGG-VVWKAVGWRLIALSFGLYGLLYVYERLTWTTRAKE--RAFKRQFVE 667

  Fly   638 AGVYPEKQE-----TQENGDESASEE-SSSDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIM 696
            ..  .||.:     |..|......:| |.:...|.:||:..|:.::..:..:.|....:......
  Rat   668 YA--SEKLQLIISYTGSNCSHQVQQELSGTFAHLCQQVDITRDNLEQEIAAMNKKVEALDSLQSK 730

  Fly   697 MLIINNAKDFINGEL--LAHLY 716
            ..::.|...:::.||  ..|.|
  Rat   731 AKLLRNKAGWLDSELNMFIHQY 752

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.