DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shi and si:dkey-32e23.4

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_005167422.1	Gene:	si:dkey-32e23.4 / 566871	ZFINID:	ZDB-GENE-081105-41	Length:	671	Species:	Danio rerio

Alignment Length:	790	Identity:	289/790 - (36%)
Similarity:	418/790 - (52%)	Gaps:	160/790 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 65
            |::||.|:|:||:.|.::|..: :.||||.|||.||:|||||||:.||:|||||||||||||||:
Zfish     1 METLIPIINRLQEVFLTVGAEI-IQLPQIVVVGSQSSGKSSVLESLVGRDFLPRGSGIVTRRPLV 64

  Fly    66 LQLIN-------------------------GV--TEYGEFLHIKGKKFSSFDEIRKEIEDETDRV 103
            |||:|                         |:  .|:|.|||.|.:.|:.|:|||||||:||||.
Zfish    65 LQLVNVPPLEERRKQDNGNGSKQNSQNNYPGIKAEEWGTFLHCKNQIFTDFNEIRKEIEEETDRS 129

  Fly   104 TGSNKGISNIPINLRVYSPHVLNLTLIDLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILA 168
            | :|||||..||.|::|||:||:|||:||||:|||.:||||.|||.|:::||..:|.....|||.
Zfish   130 T-NNKGISKEPIYLKIYSPNVLSLTLVDLPGITKVPVGDQPEDIEIQVQEMILSYISNPNSLILC 193

  Fly   169 VTPANTDLANSDALKLAKEVDPQGVRTIGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRS 233
            |:|||:|||.|||||||:|||..|.||:.|::||||||.||||.::|..:::|:|.|.|||||||
Zfish   194 VSPANSDLATSDALKLAREVDADGRRTLLVVSKLDLMDAGTDALEVLLGRVIPVRLGIIGVVNRS 258

  Fly   234 QKDIEGRKDIHQALAAERKFFLSHPSYRHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQ 298
            |.|:..:|.:..:...|:.|...|  |..:|.|.|:.||.|.|::.|.:||||.||.|:.::  .
Zfish   259 QHDLNTQKSLSDSCRDEQAFLQRH--YPSLASRCGSRYLARTLSRLLMHHIRDCLPELKTRV--T 319

  Fly   299 MLTLEKEVEEFKHFQPGDASIKTKAMLQMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFH 363
            :||.:.:.....:.||.:....|  :||::.:..:|:..||||: :..:.|:||.|||::..|||
Zfish   320 VLTAQYQSRLNSYGQPVEDHSAT--LLQIVTKFATDYCSTIEGT-ARHIQTSELCGGARMCYIFH 381

  Fly   364 ERLRFEIVKMACDE----KELRREISFAIRNIHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCV 424
            |  .|.....:.|.    .||  :|..||||..|.|..||.|:::||.:||:||..|:||.::||
Zfish   382 E--TFGRTLQSIDPLGGLTEL--DILTAIRNATGPRPALFVPEVSFELLVKKQIKRLEEPSLRCV 442

  Fly   425 DLVVQELSVVVRMC----TAKMSRYPRLREETERIITTHVRQREHSCKEQILLLIDFELAYMNTN 485
            :||.:||..:::.|    |.::.|:|:|.:....::|..:|:|.....|.:..|:..||||:||.
Zfish   443 ELVHEELQRIIQHCSSYSTQELLRFPKLHDSIVEVVTGLLRKRLPITNEMVHNLVAIELAYINTK 507

  Fly   486 HEDFIGFANAQNKSENANKTGTRQLGNQVIRKGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGG 550
            |.||...|..                                        |..:|.:......||
Zfish   508 HPDFTDAAQV----------------------------------------SASVNSQQAEAGDGG 532

  Fly   551 SRPYWFVLTSESISWYKDEDEKEKKFMLPLDGLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKDY 615
            .|            |..::...|:|..:|           ||.|.|:.:..
Zfish   533 KR------------WKNEKMPSEEKGPMP-----------GFGSPSKAINL-------------- 560

  Fly   616 KQLELSCETVEDVESWKASFLRAGVYPEKQETQENGDESASEESSSDPQLERQVETIRNLVDSYM 680
                  .:|...|                           |.:.||..|  |..|.|:.|:..|.
Zfish   561 ------LDTAVPV---------------------------SRKLSSREQ--RDCEVIQRLIKCYF 590

  Fly   681 KIVTKTTRDMVPKAIMMLIINNAKDFINGELLAHLYASGDQAQMMEESAESATRREEMLRMYRAC 745
            .||.|:.:|.|||.:|..::|..|:.:..||:..||......:::.||.|:|.:|.|:..|..|.
Zfish   591 LIVRKSIQDSVPKTVMHFLVNFVKEHLQSELVGQLYKQPLLQELLIESQETAQQRTEVAHMLEAL 655

  Fly   746 KDALQIIGDV 755
            |.|..||.::
Zfish   656 KKASNIISEI 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	148/265 (56%)
		CrfC	73..>498	CDD:223771	192/432 (44%)
		Dynamin_M	212..498	CDD:279383	104/293 (35%)
		PH_dynamin	512..644	CDD:269958	15/131 (11%)
		PH	552..638	CDD:278594	11/85 (13%)
		GED	664..755	CDD:128597	32/90 (36%)
		DUF4527	<758..819	CDD:291689
		Drf_FH1	<761..>846	CDD:283903
si:dkey-32e23.4	XP_005167422.1	DLP_1	23..312	CDD:206738	156/291 (54%)
		Dynamin_M	236..516	CDD:307257	104/290 (36%)
		GED	577..665	CDD:308047	31/87 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820