DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shi and mxf

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_017206546.2	Gene:	mxf / 561067	ZFINID:	ZDB-GENE-030721-9	Length:	646	Species:	Danio rerio

Alignment Length:	494	Identity:	158/494 - (31%)
Similarity:	257/494 - (52%)	Gaps:	48/494 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLILQL------ 68
            :|.|:...:|:...:.||.|||||.||:|||||||...|. .||||||||||.||.|:|
Zfish    40 ELIDSLRFIGLDEDIGLPSIAVVGDQSSGKSSVLEALSGV-ALPRGSGIVTRCPLELKLQKIKTG 103

  Fly    69 -INGVTEYGEFLHIKGKKFSSFDEIRKE--IEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLI 130
             .:|...|      .|.|.:..|.::.:  :....|.:.|:..||.:..|.|.:.||.|.:||||
Zfish   104 PWSGTISY------DGHKEAFSDPLKVDSLVRAAQDDLAGTTVGICDELITLEISSPDVCDLTLI 162

  Fly   131 DLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRT 195
            ||||:|:|.:..||.||..|||.:|.::|.|...:||.|.|.|.|:|.::||::|::|||:|:||
Zfish   163 DLPGITRVPVNGQPDDIGDQIKSLILKYIDKSETIILVVVPCNVDIATTEALRMAQQVDPEGLRT 227

  Fly   196 IGVITKLDLMDEGT--DARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHP 258
            :.::||.||:|.|.  |..:|::.|::||.:|||.|..|.|.||..|....:|:..|:.||.||.
Zfish   228 LAILTKPDLIDRGAEIDVLNIVQGKVIPLSKGYIIVRCRGQSDINNRVPFEKAMEDEQNFFRSHH 292

  Fly   259 SYRH-MAD-RLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKT 321
            .:.. :|| ...|..|...|.::|.:||:.::|.|.:::|.::|.:::|::.:....|
Zfish   293 YFSSLLADGNASTQCLALKLTRELGDHIKKSIPTLTEEIQNKVLNVQRELKNYDQGPP------- 350

  Fly   322 KAMLQMIQQLQSDFERTIEGSGSALVNTNELSGGAK----------INRIFHERLRFEIVKMACD 376
                 |.::|...|...|..:.|..:|....:|.::          :.|.:...||...|..
Zfish   351 -----MNEELMGPFLSEIILNFSDQINELSRTGHSQDKNLYTLLRPVFRKWDNHLRSTEVLF--- 407

  Fly   377 EKELRREISFAIRNIH-GIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVR-MCT 439
             ||...|:......|| |..:..|:....:|.:::..:|.|:||.::.::.|.:.:....| .|.
Zfish   408 -KERVTEMIEKYNEIHRGRELLTFSEFCEYECVIQNHVAALQEPAMETLNDVREIVQNKFREACY 471

  Fly   440 AKMSRYPRLREETERIITTHVRQREHSCKEQILLLIDFE 478
            ....:||.:|.....:|.....::|...:::|...|:.|
Zfish   472 LSFDQYPPMRYIISNMINDIQSKQEAKAEKRIKEFINME 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	103/240 (43%)
		CrfC	73..>498	CDD:223771	123/424 (29%)
		Dynamin_M	212..498	CDD:279383	67/281 (24%)
		PH_dynamin	512..644	CDD:269958
		PH	552..638	CDD:278594
		GED	664..755	CDD:128597
		DUF4527	<758..819	CDD:291689
		Drf_FH1	<761..>846	CDD:283903
mxf	XP_017206546.2	DLP_1	56..325	CDD:206738	115/275 (42%)
		Dynamin_M	245..517	CDD:307257	67/282 (24%)
		GED	570..644	CDD:321988
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810