DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shi and dnm2a

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_021326548.1	Gene:	dnm2a / 559334	ZFINID:	ZDB-GENE-050913-84	Length:	885	Species:	Danio rerio

Alignment Length:	896	Identity:	578/896 - (64%)
Similarity:	686/896 - (76%)	Gaps:	85/896 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 65
            |:.||.::|||||||:|:|....|||||||||||||||||||||||||:||||||||||||||||
Zfish     6 MEELIPLINKLQDAFSSIGQSCNLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLI 70

  Fly    66 LQLINGVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLI 130
            |||:|...||.||||.||:||..|||:|:|||.||||:||||||||.||||||||||:|||||||
Zfish    71 LQLVNNKAEYAEFLHCKGRKFVDFDEVRQEIEAETDRITGSNKGISPIPINLRVYSPNVLNLTLI 135

  Fly   131 DLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRT 195
            ||||:||||:||||.|||.||:.||.|||.:|:||||||||||.|||||||||:||||||||:||
Zfish   136 DLPGMTKVAVGDQPPDIEHQIRDMIMQFITRESCLILAVTPANMDLANSDALKVAKEVDPQGLRT 200

  Fly   196 IGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSY 260
            ||||||||||||||||||||||||||||||||||||||||||:|||||..|||||||||||||||
Zfish   201 IGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIDGRKDIRAALAAERKFFLSHPSY 265

  Fly   261 RHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKAML 325
            ||||:|:|||:||:.|||||||||||||||||.|||.|:|:|||||||:|:|:|.|.:.||||:|
Zfish   266 RHMAERMGTPHLQKALNQQLTNHIRDTLPGLRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALL 330

  Fly   326 QMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVKMACDEKELRREISFAIRN 390
            ||:||...|||:.|||||.. |:|.||||||:||||||||..||:||:..||||||||||.||:|
Zfish   331 QMVQQFGVDFEKCIEGSGDQ-VDTAELSGGARINRIFHERFPFELVKIVFDEKELRREISHAIKN 394

  Fly   391 IHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVRMCTAKMSRYPRLREETERI 455
            :||:|.||||||:|||||||:||..||||.:||:|||:|||....|.||.|:|.|||||||||||
Zfish   395 VHGVRTGLFTPDLAFEAIVKKQIIKLKEPCLKCIDLVIQELINTFRQCTNKLSSYPRLREETERI 459

  Fly   456 ITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIGFAN--------------AQNKSENANKTG 506
            :||:||:||...|:|:|||||.||:|:||||||||||||              :.|.::..|...
Zfish   460 VTTYVREREGKTKDQVLLLIDTELSYINTNHEDFIGFANLDLRRLDDGTIPGYSNNSAQQRNIVN 524

  Fly   507 TR-----QLG-------NQVIRKGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLT 559
            .:     |||       .:|||||.:.: |:.|||                   |||:.||||||
Zfish   525 KKRAIPNQLGGLREGEAEKVIRKGWLTL-NISIMK-------------------GGSKEYWFVLT 569

  Fly   560 SESISWYKDEDEKEKKFMLPLDGLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKDYKQLELSCET 624
            :||:||||||:|||||:|||||.|||||:|:||||...  .||:|:.:.||||||.:|:||:|::
Zfish   570 AESLSWYKDEEEKEKKYMLPLDNLKLRDVEKGFMSTKH--IFAIFNTEQRNVYKDLRQIELACDS 632

  Fly   625 VEDVESWKASFLRAGVYPEKQETQENGDESASEES-SSDPQLERQVETIRNLVDSYMKIVTKTTR 688
            .||::|||||||||||||||.:.:  .:|:|..:| |.||||||||||||||||||:.||.||.|
Zfish   633 QEDMDSWKASFLRAGVYPEKDQVE--SEEAAPADSFSMDPQLERQVETIRNLVDSYIGIVNKTIR 695

  Fly   689 DMVPKAIMMLIINNAKDFINGELLAHLYASGDQAQMMEESAESATRREEMLRMYRACKDALQIIG 753
            |::||.||.|:||:|||||:.||||:||:||||..:|||||:.|.||:||||||.|.|:||.|||
Zfish   696 DLMPKTIMHLMINSAKDFIHSELLAYLYSSGDQNSLMEESADQAQRRDEMLRMYHAIKEALSIIG 760

  Fly   754 DVSMATVSSPLPPPVKNDWLPSGLDNPRLSPPS-------PGGVRG-KPGPPAQSSLGGRNPPLP 810
            |:|.:|:|:|:||||.:.|:|.....|:..||:       |..||| .|||          |||.
Zfish   761 DISTSTISTPVPPPVNDSWIPETSPTPQRRPPTSAPPPNRPPAVRGPTPGP----------PPLN 815

  Fly   811 PSTGRPAPAIPNRPGG-------------GAPPLPGGRPGGSLPPPMLPSR 848
            |:....||.||:|||.             .|||....||  :..||.:|||
Zfish   816 PTPSFAAPPIPSRPGQPMNAFGNSSQDPFSAPPQIPSRP--ARIPPGVPSR 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	197/238 (83%)
		CrfC	73..>498	CDD:223771	327/438 (75%)
		Dynamin_M	212..498	CDD:279383	213/299 (71%)
		PH_dynamin	512..644	CDD:269958	74/131 (56%)
		PH	552..638	CDD:278594	56/85 (66%)
		GED	664..755	CDD:128597	65/90 (72%)
		DUF4527	<758..819	CDD:291689	24/68 (35%)
		Drf_FH1	<761..>846	CDD:283903	36/105 (34%)
dnm2a	XP_021326548.1	DYNc	6..245	CDD:197491	197/238 (83%)
		Dynamin_M	216..498	CDD:307257	212/282 (75%)
		PH_dynamin	544..652	CDD:269958	74/129 (57%)
		GED	674..762	CDD:308047	62/87 (71%)
		Atrophin-1	<764..882	CDD:331285	40/113 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	438	1.000	Domainoid score	I538
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1121	1.000	Inparanoid score	I214
OMA	1	1.010	-	-		QHG52581
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	1	1.000	-	-		FOG0001563
OrthoInspector	1	1.000	-	-		otm24243
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X876
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840