DRSC/TRiP Functional Genomics Resources

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Protein Alignment shi and MFN1

DIOPT Version :9

Sequence 1:NP_001259588.1 Gene:shi / 45928 FlyBaseID:FBgn0003392 Length:896 Species:Drosophila melanogaster
Sequence 2:NP_284941.2 Gene:MFN1 / 55669 HGNCID:18262 Length:741 Species:Homo sapiens


Alignment Length:836 Identity:143/836 - (17%)
Similarity:273/836 - (32%) Gaps:276/836 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 QDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLILQLINGVTEYG 76
            :|..:.:|..:.....::|..|..|:|||||:...:....||.|.|.:|...|.::..:|...| 
Human    61 KDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDGDKAY- 124

  Fly    77 EFLHIKG----KKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVL------NLTLID 131
              |..:|    |...:.:::...:..:.|...|         ..:||:.|...      :|.|:|
Human   125 --LMTEGSDEKKSVKTVNQLAHALHMDKDLKAG---------CLVRVFWPKAKCALLRDDLVLVD 178

  Fly   132 LPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRTI 196
            .||          .|:..::...|.:|.......:|.....:| |.|::.....|..:......|
Human   179 SPG----------TDVTTELDSWIDKFCLDADVFVLVANSEST-LMNTEKHFFHKVNERLSKPNI 232

  Fly   197 GVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKD------IEGRKDIHQALAAERKFFL 255
            .::.  :..|......:.:|:            |.|...:      :|..|.::...|..|.||:
Human   233 FILN--NRWDASASEPEYMED------------VRRQHMERCLHFLVEELKVVNALEAQNRIFFV 283

  Fly   256 SHPSYRHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQ---KQMLTLEK----EVEEFKHFQ 313
            |                           .::.|...:.|.|   :..:.|.:    .::||::|:
Human   284 S---------------------------AKEVLSARKQKAQGMPESGVALAEGFHARLQEFQNFE 321

  Fly   314 P------GDASIKTKAMLQMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVK 372
            .      ..:::|||            ||:....:...|.....:..  .:|....::..:.:  
Human   322 QIFEECISQSAVKTK------------FEQHTIRAKQILATVKNIMD--SVNLAAEDKRHYSV-- 370

  Fly   373 MACDEKELRREISFAIRNIHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQE----LSV 433
               :|:|.:.:....|||    ::.|.|.|      ||::|..:.|.|...|...:.:    |||
Human   371 ---EEREDQIDRLDFIRN----QMNLLTLD------VKKKIKEVTEEVANKVSCAMTDEICRLSV 422

  Fly   434 VVRMCTAKMSRYPRLREETERIITTHV-----RQREHSCKEQILLLI------------------ 475
            :|....::....|.:.:..:..:..|:     |.....|.:::..|:                  
Human   423 LVDEFCSEFHPNPDVLKIYKSELNKHIEDGMGRNLADRCTDEVNALVLQTQQEIIENLKPLLPAG 487

  Fly   476 ------------DFELAYMNTNH--------ED---------------FIGFANAQNKSENANKT 505
                        .|:|:| |.|:        ||               |:|..|||.        
Human   488 IQDKLHTLIPCKKFDLSY-NLNYHKLCSDFQEDIVFRFSLGWSSLVHRFLGPRNAQR-------- 543

  Fly   506 GTRQLGNQVIRKGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLTSESISWYKDED 570
                                     :.||.|.|:   |..|.:..|.|     |:.:.....|..
Human   544 -------------------------VLLGLSEPI---FQLPRSLASTP-----TAPTTPATPDNA 575

  Fly   571 EKEKKFMLPLDGLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKD----------------YKQLE 619
            .:|:..:..:.||         .|::.|.:..:....| .::|.                |....
Human   576 SQEELMITLVTGL---------ASVTSRTSMGIIIVGG-VIWKTIGWKLLSVSLTMYGALYLYER 630

  Fly   620 LSCETVEDVESWKASFLRAGVYPEKQETQENGDESASEESSSDPQLERQVETIRNLVDSYMKIVT 684
            ||..|.....::|..|:       ...|::.....:|..::...|:::|:.|....:...:.|..
Human   631 LSWTTHAKERAFKQQFV-------NYATEKLRMIVSSTSANCSHQVKQQIATTFARLCQQVDITQ 688

  Fly   685 KTTRDMV---PKAIMML--IINNAKDFINGELLAHLYASGDQAQMMEESAESATRR 735
            |...:.:   ||.|..|  |.||:|...|            :|..:|...|:.|::
Human   689 KQLEEEIARLPKEIDQLEKIQNNSKLLRN------------KAVQLENELENFTKQ 732

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
shiNP_001259588.1 DYNc 1..240 CDD:197491 45/243 (19%)
CrfC 73..>498 CDD:223771 83/515 (16%)
Dynamin_M 212..498 CDD:279383 59/366 (16%)
PH_dynamin 512..644 CDD:269958 23/147 (16%)
PH 552..638 CDD:278594 16/101 (16%)
GED 664..755 CDD:128597 18/77 (23%)
DUF4527 <758..819 CDD:291689
Drf_FH1 <761..>846 CDD:283903
MFN1NP_284941.2 Part of a helix bundle domain, formed by helices from N-terminal and C-terminal regions. /evidence=ECO:0000269|PubMed:16959974, ECO:0000269|PubMed:28114303 9..73 2/11 (18%)
DLP_2 76..328 CDD:206739 56/315 (18%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 82..89 3/6 (50%)