DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shi and opa1

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_009300789.1	Gene:	opa1 / 492332	ZFINID:	ZDB-GENE-041114-7	Length:	1034	Species:	Danio rerio

Alignment Length:	517	Identity:	123/517 - (23%)
Similarity:	218/517 - (42%)	Gaps:	98/517 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLITIVNKLQDAFTSL--GVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSG-IVTRRPL 64
            |||.:.:::.|..:..  ..:.|..||::.|||.|||||:||||........||||| ::||.|:
Zfish   337 SLIDMYSEVLDILSDYDSNYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPV 401

  Fly    65 ILQLINGVTEYGEFLHIKGKKFSS--FD--------EIRKEIEDETDRVTGSNKGISNIPINLRV 119
            .:.|..|..      |:...|.||  ||        .:|.|||....:.....:.:|...|:|.|
Zfish   402 KVTLSEGPH------HVAMFKDSSREFDLGKEEDLAALRHEIELRMRKSVKEGQTVSPETISLSV 460

  Fly   120 YSPHVLNLTLIDLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKL 184
            ..|.:..:.|:||||:..........|.::.|..:...:::....:||.:...:.|...|....|
Zfish   461 KGPGIQRMVLVDLPGVISTVTTGMAADTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDL 525

  Fly   185 AKEVDPQGVRTIGVITKLDLMDEG----TDARDILENKLLPLRR-GYIGVV---NRSQKDIEGRK 241
            ..::||||.|||.|:||:||.::.    :..:.|:|.||.|::. ||..||   ....:.|:..|
Zfish   526 VSQMDPQGKRTIFVLTKVDLAEKNLASPSRIQQIVEGKLFPMKALGYFAVVTGKGSPNESIDSIK 590

  Fly   242 DIHQALAAERKFFLSHPSYRHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEV 306
            |.      |..||   .:.|.:.|  |.....:|..:.|:..:.|..    .|:.::  ::|::.
Zfish   591 DY------EEDFF---QNSRLLKD--GMLKAHQVTTKNLSLAVSDCF----WKMVRE--SVEQQA 638

  Fly   307 EEFKHFQPGDASIKTKAMLQMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIV 371
            :.||           .:...:..:.::::.|..|      ::.|||...|| |.|..|.:....|
Zfish   639 DAFK-----------ASRFNLETEWKNNYPRLRE------LDRNELYEKAK-NEILDEVISLSQV 685

  Fly   372 KMACDEKELRREI-----SFAIRNIH----------------GIRVGLFTP--------DMAFEA 407
            .....|..|::::     :..|.||:                .|::..:|.        ::|:|.
Zfish   686 TPKHWESILQKKLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLPHKALEVAWET 750

  Fly   408 IVKRQIALLKEPVIKCVDLVVQELSVVVRMCTAKMSRYPRLREETERIITTHVRQREHSCKE 469
            :.:.....:.|...|..|.:..:|...|:..:.|..::.....::.|:|       :|:..|
Zfish   751 LQEEFARFMAEYKGKDQDDIFDKLKEAVKDESIKRHKWNERAMDSLRVI-------QHNALE 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	78/257 (30%)
		CrfC	73..>498	CDD:223771	94/444 (21%)
		Dynamin_M	212..498	CDD:279383	55/291 (19%)
		PH_dynamin	512..644	CDD:269958
		PH	552..638	CDD:278594
		GED	664..755	CDD:128597
		DUF4527	<758..819	CDD:291689
		Drf_FH1	<761..>846	CDD:283903
opa1	XP_009300789.1	DLP_1	361..635	CDD:206738	85/296 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810