DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment shi and MX1

DIOPT Version :9

Sequence 1:NP_001259588.1 Gene:shi / 45928 FlyBaseID:FBgn0003392 Length:896 Species:Drosophila melanogaster
Sequence 2:NP_001138397.1 Gene:MX1 / 4599 HGNCID:7532 Length:662 Species:Homo sapiens


Alignment Length:627 Identity:190/627 - (30%)
Similarity:309/627 - (49%) Gaps:98/627 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 LQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLIL---QLIN-- 70
            |.|:..:|||...|.||.|||:|.||:|||||||...|. .||||||||||.||:|   :|:|  
Human    55 LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGV-ALPRGSGIVTRCPLVLKLKKLVNED 118

  Fly    71 ---GVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLIDL 132
               |...|.::    ..:.|...|:.|||....:.:.|...|||:..|.|.:.|..|.:||||||
Human   119 KWRGKVSYQDY----EIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDL 179

  Fly   133 PGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRTIG 197
            ||:|:||:|:||.||..:||.:|.::|:::..:.|.|.|:|.|:|.::||.:|:||||:|.||||
Human   180 PGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIG 244

  Fly   198 VITKLDLMDEGTDAR--DILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSY 260
            ::||.||:|:||:.:  |::.|.:..|::||:.|..|.|::|:.:..:.:||..|:.||.:||.:
Human   245 ILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSEALQREKIFFENHPYF 309

  Fly   261 RHMAD--RLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKA 323
            |.:.:  :...|.|...|..:|..||..:||.|.:::::....:.:|::::....|.|.:.|...
Human   310 RDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPEDENEKMFF 374

  Fly   324 MLQMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVKMAC--------DEKEL 380
            ::..:.....|.        :||:...|..|...| |:| .|||.|..|.:.        ..|.|
Human   375 LIDKVNAFNQDI--------TALMQGEETVGEEDI-RLF-TRLRHEFHKWSTIIENNFQEGHKIL 429

  Fly   381 RREISFAIRNIHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVRMC------- 438
            .|:|........|..:..|.....||.|||:||..|:||.:..:..|..    :||:.       
Human   430 SRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTD----MVRLAFTDVSIK 490

  Fly   439 ----------TAKMSRYPRLREETER----IITTHVRQRE-HSCKEQILLLIDFELAYMNTNHE- 487
                      ||| |:...:|.|.||    :|..|.:..: ..|::|:     :..|......: 
Human   491 NFEEFFNLHRTAK-SKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQV-----YRGALQKVREKE 549

  Fly   488 ----------DFIGFANAQNKSENANKTGTRQLGNQVIRKGHMVIQNLGIMKDIKLGRSGPLNVR 542
                      ||..|     :|.:|..:...::..      |::..:....|  ::....||.::
Human   550 LEEEKKKKSWDFGAF-----QSSSATDSSMEEIFQ------HLMAYHQEASK--RISSHIPLIIQ 601

  Fly   543 FFSPSTGGSRPYWFVL----TSESISWY---KDEDEKEKKFM 577
            ||...|.|.:....:|    ..::.||.   :.:...::||:
Human   602 FFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDTSDKRKFL 643

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shiNP_001259588.1 DYNc 1..240 CDD:197491 106/238 (45%)
CrfC 73..>498 CDD:223771 137/469 (29%)
Dynamin_M 212..498 CDD:279383 78/330 (24%)
PH_dynamin 512..644 CDD:269958 13/73 (18%)
PH 552..638 CDD:278594 5/33 (15%)
GED 664..755 CDD:128597
DUF4527 <758..819 CDD:291689
Drf_FH1 <761..>846 CDD:283903
MX1NP_001138397.1 DLP_1 68..340 CDD:206738 115/276 (42%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 77..84 4/6 (67%)
G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 102..104 1/1 (100%)
G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 178..181 2/2 (100%)
G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 247..250 2/2 (100%)
Dynamin_M 260..546 CDD:395818 75/305 (25%)
G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 279..282 0/2 (0%)
Bundle signaling element (BSE) 341..366 2/24 (8%)
Middle domain 366..533 44/181 (24%)
Stalk 367..632 63/297 (21%)
Critical for lipid-binding 554..557 0/2 (0%)
GED 571..660 CDD:128597 13/81 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0699
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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