DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shi and mxb

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_009304072.1	Gene:	mxb / 360143	ZFINID:	ZDB-GENE-030721-6	Length:	627	Species:	Danio rerio

Alignment Length:	496	Identity:	161/496 - (32%)
Similarity:	265/496 - (53%)	Gaps:	54/496 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 DAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLILQLINGVTE--- 74
            |...||||...|.||.|||:|.||:|||||||...|.. ||||||||||.||.|::|....:
Zfish    24 DNLRSLGVEKDLALPAIAVIGDQSSGKSSVLEALSGVP-LPRGSGIVTRCPLELKMIRSKEDEKW 87

  Fly    75 YGEFLHIKGKKFSSFD---EIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLIDLPGLT 136
            :|...:...::  .||   |:.|:|.:..|.:.|:..|||...|:|::.|.:|.:||||||||:.
Zfish    88 HGRISYQNHEE--DFDDPAEVEKKIREAQDEMAGAGVGISEELISLQITSANVPDLTLIDLPGIA 150

  Fly   137 KVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRTIGVITK 201
            :||:..||.:|..|||::|..||.|:..:.|.|.|.|.|:|.::||::|:..||:|.||:|::||
Zfish   151 RVAVKGQPENIGDQIKRLIRMFITKQETINLVVVPCNVDIATTEALQMAQAEDPEGERTLGILTK 215

  Fly   202 LDLMDEGTDAR--DILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSYRHMA 264
            .||:|:||:..  ||:.|:::.|.:||:.|..|.||:|..:..:::|...|..||..||.:|.:.
Zfish   216 PDLVDKGTEGTVVDIVHNEVIHLTKGYMIVRCRGQKEIMDQVTLNEATETESAFFKDHPHFRKLY 280

  Fly   265 DR--LGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKAMLQM 327
            :.  ...|.|...|..:|.:||:.:||.|.:::|.::...:||:|.:....|.|.:.:....:..
Zfish   281 EEGFATIPKLAEKLTIELVHHIQRSLPRLEEQIQTKLAETQKELEAYGDGPPSDPAERLSFFIDK 345

  Fly   328 IQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIV-------------KMACDEKE 379
            :.....|   |:.     |....|:...:|: .||.| ||.|..             |:..:|:.
Zfish   346 VTAFTCD---TLN-----LTTGEEVKSASKL-LIFPE-LRQEFAYWNSFLDSSGYSFKLKIEEEV 400

  Fly   380 LRREISFAIRNIHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCV----DLVVQELSVVVRMCTA 440
            ...|:.:..|.:.|     |.....||.:|:.|:.||:||.:|.:    |:|.::.   :::..:
Zfish   401 DNYEVKYRGRELPG-----FINYKTFEGLVREQMKLLEEPALKMLKNVSDMVKKKF---IQLAQS 457

  Fly   441 KMSRYPRLREETERIITTHVR--QREHSCKEQILLLIDFEL 479
            ..:.:|.|.    :|..|.:.  :::..|..:.:|...|::
Zfish   458 SFTGFPILL----KIAKTKIEAIKQDKECLAESMLRTQFKM 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	104/234 (44%)
		CrfC	73..>498	CDD:223771	125/436 (29%)
		Dynamin_M	212..498	CDD:279383	68/291 (23%)
		PH_dynamin	512..644	CDD:269958
		PH	552..638	CDD:278594
		GED	664..755	CDD:128597
		DUF4527	<758..819	CDD:291689
		Drf_FH1	<761..>846	CDD:283903
mxb	XP_009304072.1	DLP_1	35..307	CDD:206738	112/274 (41%)
		Dynamin_M	228..509	CDD:279383	68/289 (24%)
		GED	537..625	CDD:128597
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810