DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shi and mxe

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_005167721.2	Gene:	mxe / 337663	ZFINID:	ZDB-GENE-030131-9609	Length:	657	Species:	Danio rerio

Alignment Length:	627	Identity:	194/627 - (30%)
Similarity:	308/627 - (49%)	Gaps:	95/627 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLILQL------- 68
            |.|:..:|||...|:||.|||:|.||:|||||||...|. .||||:|||||.||:|:|
Zfish    60 LVDSLRALGVEKDLNLPAIAVIGDQSSGKSSVLEALSGV-ALPRGTGIVTRCPLVLKLKKITKDK 123

  Fly    69 -INGVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLIDL 132
             .:|:..|.:    |.::.....:|.|.:.:....:.|..:|||:..|.|.:.|..|.:||||||
Zfish   124 SWHGLLTYND----KIRELKDPAKIEKAVLNAQTALAGIGEGISHEMITLEIQSCDVPDLTLIDL 184

  Fly   133 PGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRTIG 197
            ||:.:||.|:||.|||:|||.:|.:||:::..:.|.|.|||.|:|.::|||:|..|||.|.||:|
Zfish   185 PGIARVATGNQPEDIEKQIKSLIEKFIKRQETISLVVVPANIDIATTEALKMASTVDPTGQRTLG 249

  Fly   198 VITKLDLMDEGTDARDI--LENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSY 260
            ::||.||:|.|.:...:  :.|:::||::||:.|..|.|:||..:..:.:||..||:||..:..:
Zfish   250 ILTKPDLVDRGMEDTVVRTVNNEVIPLKKGYMIVKCRGQQDINDKLGLVEALEKERRFFDENVHF 314

  Fly   261 RH-MADRLGT-PYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPG---DASIK 320
            |. :.||..| |.|...|.::|..||...||.|:::|:   :.|||...:.:....|   |.:.|
Zfish   315 RSLLEDRKATIPLLAERLTKELVEHIAKNLPQLQNQLE---MKLEKTSADLRGLGDGVPLDKNEK 376

  Fly   321 TKAMLQMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIV--------KMACDE 377
            :..::..|:|.....|| ::.:...:...|        .|:| .::|.|.|        |....|
Zfish   377 SNFLIMKIRQFNDVLER-VQMAEEDVEKPN--------TRVF-SKIRSEFVKWKRILDSKAIKTE 431

  Fly   378 KELRREISFAIRNIHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCV----DLVVQELSVVVRMC 438
            :.||.|:...::...|..:..|.....||.|||:.||.|.||.:|.:    |:|...:..:|...
Zfish   432 ETLRDEVQEYVKTRRGKELPGFVNYRTFENIVKKHIAELHEPALKLLKDVTDIVHSSVDHIVNAH 496

  Fly   439 TAKMSRYPR-LREETERIITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIG--FANAQN--- 497
            .:..|...| .::.||..:....::.|.....|      |.:..:..:.:|...  ...|:|
Zfish   497 FSSFSPLMRAAKDPTEDFLHEQFQRAEEKIHSQ------FRMEKIVYSQDDLYSDQLTTAKNTLR 555

  Fly   498 ----KSENAN--------------KTGTRQLGNQV--IRKGHMVIQNLGIMKDIKLGRSGPLNVR 542
                :|.|.:              .....:|.||:  |.:.||:.|.:..:::..||..|
Zfish   556 GYGLQSPNVSADVREMAYHLTSYLTIACERLANQIPLIVQYHMLNQYISQLQNAMLGLIG----- 615

  Fly   543 FFSPSTGGSRPYWFVLTSESISWYKDEDEKEKKFMLPLDGLK 584
              ..|.|      .:|..:|....|.:|.||:     |:.||
Zfish   616 --KNSPG------MLLCEDSGVARKRKDLKER-----LERLK 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	104/238 (44%)
		CrfC	73..>498	CDD:223771	135/453 (30%)
		Dynamin_M	212..498	CDD:279383	77/314 (25%)
		PH_dynamin	512..644	CDD:269958	20/75 (27%)
		PH	552..638	CDD:278594	9/33 (27%)
		GED	664..755	CDD:128597
		DUF4527	<758..819	CDD:291689
		Drf_FH1	<761..>846	CDD:283903
mxe	XP_005167721.2	DLP_1	73..345	CDD:206738	115/276 (42%)
		Dynamin_M	266..552	CDD:279383	76/304 (25%)
		GED	568..653	CDD:280391	21/95 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910