DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shi and DNM3

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_016856465.1	Gene:	DNM3 / 26052	HGNCID:	29125	Length:	921	Species:	Homo sapiens

Alignment Length:	933	Identity:	576/933 - (61%)
Similarity:	680/933 - (72%)	Gaps:	126/933 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 65
            |:.||.:||:|||||::||....|:|||||||||||||||||||||||:|||||||||||||||:
Human     6 MEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLV 70

  Fly    66 LQLINGVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLI 130
            |||:....||.||||.|||||:.|||:|.|||.|||||||.|||||:||||||||||||||||||
Human    71 LQLVTSKAEYAEFLHCKGKKFTDFDEVRLEIEAETDRVTGMNKGISSIPINLRVYSPHVLNLTLI 135

  Fly   131 DLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRT 195
            ||||:|||.:||||.|||.||::||.|||.:|.|||||||||||||||||||||||||||||:||
Human   136 DLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLILAVTPANTDLANSDALKLAKEVDPQGLRT 200

  Fly   196 IGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSY 260
            ||||||||||||||||||:||||||||||||:||||||||||:|:|||..|:.||||||||||:|
Human   201 IGVITKLDLMDEGTDARDVLENKLLPLRRGYVGVVNRSQKDIDGKKDIKAAMLAERKFFLSHPAY 265

  Fly   261 RHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKAML 325
            ||:|||:|||:||:|||||||||||||||..|:|||.|:|::|.|||.:|:|:|.|.:.||||:|
Human   266 RHIADRMGTPHLQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEVEAYKNFKPEDPTRKTKALL 330

  Fly   326 QMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVKMACDEKELRREISFAIRN 390
            ||:||...|||:.|||||.. |:|.|||||||||||||||..||||||..:|||||||||:||:|
Human   331 QMVQQFAVDFEKRIEGSGDQ-VDTLELSGGAKINRIFHERFPFEIVKMEFNEKELRREISYAIKN 394

  Fly   391 IHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVRMCTAKMSRYPRLREETERI 455
            |||||.||||||||||||||:||..||.|.:|.||||:|||...|:.||.|::.:|||.||||||
Human   395 IHGIRTGLFTPDMAFEAIVKKQIVKLKGPSLKSVDLVIQELINTVKKCTKKLANFPRLCEETERI 459

  Fly   456 ITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIGFANAQNKSENANKTGTRQLGNQ------- 513
            :..|:|:||...|:|:|||||.:::|:||||||||||||||.:|...:|..|  :|||
Human   460 VANHIREREGKTKDQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHKKTT--VGNQGTNLPPS 522

  Fly   514 ---VIRKGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLTSESISWYKDED----- 570
               |||||.:.|.|:||||                   |||:.||||||:||:|||||::
Human   523 RQIVIRKGWLTISNIGIMK-------------------GGSKGYWFVLTAESLSWYKDDEIPSQT 568

  Fly   571 -------------------------------------------EKEKKFMLPLDGLKLRDIEQGF 592
                                                       |||||:|||||.||:||:|:.|
Human   569 GLLPDLQQGFPLLPHEIYSNQRCKEHLNSYFLQEVFPDHLQLKEKEKKYMLPLDNLKVRDVEKSF 633

  Fly   593 MSMSRRVTFALFSPDGRNVYKDYKQLELSCETVEDVESWKASFLRAGVYPEKQ------ETQENG 651
            || |:.: ||||:.:.|||||||:.|||:|::.|||:|||||.|||||||:|.      |..|||
Human   634 MS-SKHI-FALFNTEQRNVYKDYRFLELACDSQEDVDSWKASLLRAGVYPDKSVGNNKAENDENG 696

  Fly   652 DESASEESSSDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLIINNAKDFINGELLAHLY 716
            .   :|..|.|||||||||||||||||||.|:.|..||::||.||.|:|||.|||||.||||.||
Human   697 Q---AENFSMDPQLERQVETIRNLVDSYMSIINKCIRDLIPKTIMHLMINNVKDFINSELLAQLY 758

  Fly   717 ASGDQAQMMEESAESATRREEMLRMYRACKDALQIIGDVSMATVSSPLPPPVKNDWLPSGLDNPR 781
            :|.||..:||||||.|.||:||||||:|.|:||.||||:|.||||:|.||||.:.|    :.:.|
Human   759 SSEDQNTLMEESAEQAQRRDEMLRMYQALKEALGIIGDISTATVSTPAPPPVDDSW----IQHSR 819

  Fly   782 LSPPSPGGVRGKPGPPAQSSLGGRNPPLP-----PSTGR-PAPAIPN-RPGGGAPPLPGGRPGGS 839
            .|||        |.|..|     |.|.|.     |::|| ||||||: .|..||||:| .|||..
Human   820 RSPP--------PSPTTQ-----RRPTLSAPLARPTSGRGPAPAIPSPGPHSGAPPVP-FRPGPL 870

  Fly   840 LP----------PPMLPSRVSGA 852
            .|          ||.:|||.:.|
Human   871 PPFPSSSDSFGAPPQVPSRPTRA 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	195/238 (82%)
		CrfC	73..>498	CDD:223771	319/424 (75%)
		Dynamin_M	212..498	CDD:279383	202/285 (71%)
		PH_dynamin	512..644	CDD:269958	78/189 (41%)
		PH	552..638	CDD:278594	56/133 (42%)
		GED	664..755	CDD:128597	65/90 (72%)
		DUF4527	<758..819	CDD:291689	25/66 (38%)
		Drf_FH1	<761..>846	CDD:283903	38/101 (38%)
DNM3	XP_016856465.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	442	1.000	Domainoid score	I542
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1133	1.000	Inparanoid score	I221
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52581
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	1	1.000	-	-		FOG0001563
OrthoInspector	1	1.000	-	-		otm42088
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2499
SonicParanoid	1	1.000	-	-		X876
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.910