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Protein Alignment shi and Mfn1

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_620432.1	Gene:	Mfn1 / 192647	RGDID:	621460	Length:	741	Species:	Rattus norvegicus

Alignment Length:	816	Identity:	144/816 - (17%)
Similarity:	266/816 - (32%)	Gaps:	283/816 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 HMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLILQLINGVTEYGEFLHIKG-- 83
            ||     ::|..|..|:|||||:...:....||.|.|..|...|.::..:|...|   |..:|
  Rat    75 HM-----KVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKAY---LMTEGSD 131

  Fly    84 --KKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVL------NLTLIDLPGLTKVAI 140
              |...:.:::...:..:.|...|         ..:.|:.|...      :|.|:|.||
  Rat   132 EKKSVKTVNQLAHALHMDKDLKAG---------CLVHVFWPKAKCALLRDDLVLVDSPG------ 181

  Fly   141 GDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRTIGVITKLDLM 205
                .|:..::...|.:|.......:|.....:| |.|::.....|..:......|.::.  :..
  Rat   182 ----TDVTTELDIWIDKFCLDADVFVLVANSEST-LMNTEKHFFHKVNERLSKPNIFILN--NRW 239

  Fly   206 DEGTDARDILENKLLPLRRGYIGVVNRSQKD------IEGRKDIHQALAAERKFFLSHPSYRHMA 264
            |......:.:|:            |.|...:      :|..|.:....|..|.||:|
  Rat   240 DASASEPEYMED------------VRRQHMERCLHFLVEELKVVSPLEARNRIFFVS-------- 284

  Fly   265 DRLGTPYLQRVLNQQLTNHIRDTLP----GLRDKLQKQMLTLEKEVEEFKHFQP------GDASI 319
                   .:.|||.::..  ...:|    .|.:..|.::       :||::|:.      ..:::
  Rat   285 -------AKEVLNSRMNK--AQGMPEGGGALAEGFQARL-------QEFQNFEQTFEECISQSAV 333

  Fly   320 KTKAMLQMIQQLQ-SDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVKMACDEKELRRE 383
            |||.....|:..| .|..:.|..|    ||.     .|...|::           :.:|:|.:.:
  Rat   334 KTKFEQHTIRAKQILDTVKNILDS----VNV-----AAAEKRVY-----------SMEEREDQID 378

  Fly   384 ISFAIRNIHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQE----LSVVV--------- 435
            ....|||    ::.|.|.|      ||::|..:.|.|...|...:.:    |||:|
  Rat   379 RLDFIRN----QMNLLTMD------VKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHP 433

  Fly   436 -------------------------RMCTAK-----MSRYPRLREETERIITTHVRQREHS---C 467
                                     ..||::     :.....:.|..:.::...::.:.|:   |
  Rat   434 TPSVLKVYKSELNKHIEDGMGRNLADRCTSEVNASILQSQQEIIENLKPLLPAGIQNKLHTLIPC 498

  Fly   468 KE----------------QILLLIDFELAYMNTNHEDFIGFANAQNKSENANKTGTRQLGNQVIR 516
            |:                |..::..|.|.:.:..|. |:|..|||.
  Rat   499 KKFDLSYDLNCHKLCSDFQEDIVFRFSLGWSSLVHR-FLGSTNAQR------------------- 543

  Fly   517 KGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLTSESISWYKDEDEKEKKFMLPLD 581
                          :.||.|.|:   |..|.:..|.|     |:.|.....|...:|:..:..:.
  Rat   544 --------------VLLGLSEPI---FQVPRSLASTP-----TAPSNPAAPDNAAQEELMITLIT 586

  Fly   582 GLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKD------------------YKQLELSCETVEDV 628
            ||         .|::.|.:..:....| .::|.                  |::|..:....|
  Rat   587 GL---------ASLTSRTSMGIIVVGG-VIWKTVGWKLISVTLSMYGALYLYERLTWTTRAKE-- 639

  Fly   629 ESWKASFLRAGVYPEKQE-----TQENGDESASEESS------------SDPQLERQVETIRNLV 676
            .::|..|:....  ||.:     |..|......:|.:            :...||.::..:...:
  Rat   640 RAFKQQFVNYAT--EKLQMIVKFTSANCSHQVQQEMATTFARLCQQVDVTQKHLEEEIARLSKEI 702

  Fly   677 DSYMKIV--TKTTRDMVPKAIMM--LIINNAKDFIN 708
            |...||.  :|..|:   ||:.:  .:.|.:|.|::
  Rat   703 DQLEKIQNNSKLLRN---KAVQLERELENFSKQFLH 735

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.