DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shi and dyn-1

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_001024332.1	Gene:	dyn-1 / 181644	WormBaseID:	WBGene00001130	Length:	838	Species:	Caenorhabditis elegans

Alignment Length:	863	Identity:	554/863 - (64%)
Similarity:	662/863 - (76%)	Gaps:	53/863 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 65
            |.:||.::|::||||:.||..:..:||||||||||||||||||||||||||||||||||||||||
Worm     8 MQALIPVINRVQDAFSQLGTSVSFELPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 72

  Fly    66 LQLINGVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLI 130
            ||||....||.||||.||.:|..||.:|||||||||||||.|||||..||||||:||:|||||||
Worm    73 LQLIQDRNEYAEFLHKKGHRFVDFDAVRKEIEDETDRVTGQNKGISPHPINLRVFSPNVLNLTLI 137

  Fly   131 DLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRT 195
            ||||||||.:||||.||||||:.||..||.:||||||||||||:|||.||||||||||||||:||
Worm   138 DLPGLTKVPVGDQPADIEQQIRDMILTFINRETCLILAVTPANSDLATSDALKLAKEVDPQGLRT 202

  Fly   196 IGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSY 260
            |||:|||||||||||||:||||||..|||||:|||||.||||.|||||..||.||||||:|||||
Worm   203 IGVLTKLDLMDEGTDAREILENKLFTLRRGYVGVVNRGQKDIVGRKDIRAALDAERKFFISHPSY 267

  Fly   261 RHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKAML 325
            |||||||||.|||..||||||||||||||.|||.|||:|..:||:|.|:|::||.|...||||:|
Worm   268 RHMADRLGTSYLQHTLNQQLTNHIRDTLPTLRDSLQKKMFAMEKDVAEYKNYQPNDPGRKTKALL 332

  Fly   326 QMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVKMACDEKELRREISFAIRN 390
            ||:.|..:|.||:||||.:.||:||||||||:|||:||||..||||||..||||:|:||.:||||
Worm   333 QMVTQFNADIERSIEGSSAKLVSTNELSGGARINRLFHERFPFEIVKMEIDEKEMRKEIQYAIRN 397

  Fly   391 IHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVRMCTAKMSRYPRLREETERI 455
            ||||||||||||||||||.|:||..||||.:|||||||.||:.|:|.|...|:||||||:|.|||
Worm   398 IHGIRVGLFTPDMAFEAIAKKQITRLKEPSLKCVDLVVNELANVIRQCADTMARYPRLRDELERI 462

  Fly   456 ITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIGFANAQNKSENANKTGTRQLGNQVIRKGHM 520
            :.:|:|:||...|:||.|::|:|||||||||||||||:||:.|: :..::..:.|||||||||.:
Worm   463 VVSHMREREQIAKQQIGLIVDYELAYMNTNHEDFIGFSNAEAKA-SQGQSAKKNLGNQVIRKGWL 526

  Fly   521 VIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLTSESISWYKDEDEKEKKFMLPLDGLKL 585
            .:.|:..::                    ||:..||||.|:|:|||||::|||||:||||||:||
Worm   527 SLSNVSFVR--------------------GSKDNWFVLMSDSLSWYKDDEEKEKKYMLPLDGVKL 571

  Fly   586 RDIEQGFMSMSRRVTFALFSPDGRNVYKDYKQLELSCETVEDVESWKASFLRAGVYPEKQETQEN 650
            :|||.||||.:.:  ||||.|||:|:|||||||||.|..::::::|||||||||||||||:.||:
Worm   572 KDIEGGFMSRNHK--FALFYPDGKNIYKDYKQLELGCTNLDEIDAWKASFLRAGVYPEKQKAQED 634

  Fly   651 GDESASEESSSDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLIINNAKDFINGELLAHL 715
            ..:...|::|.|||||||||||||||||||:|:|||.:|:||||:|.||:|...:|:..||||||
Worm   635 ESQQEMEDTSIDPQLERQVETIRNLVDSYMRIITKTIKDLVPKAVMHLIVNQTGEFMKDELLAHL 699

  Fly   716 YASGDQAQMMEESAESATRREEMLRMYRACKDALQIIGDVSMATVSSPLPPPVKNDWLPSGLDNP 780
            |..||...:||||...|.:||||||||.|||:||:||.:|:|:|:... |||     ||.....|
Worm   700 YQCGDTDALMEESQIEAQKREEMLRMYHACKEALRIISEVNMSTLGDQ-PPP-----LPMSDYRP 758

  Fly   781 RLSPPSPGGVRGKPGPPAQSSLGGRNPPLPPSTGRPAPAIPNRPGGGAPPLPGGRP-------GG 838
            ..|.||| ..|..|.||     |||..|:||           |.|.||||.||.||       ||
Worm   759 HPSGPSP-VPRPAPAPP-----GGRQAPMPP-----------RGGPGAPPPPGMRPPPGAPGGGG 806

  Fly   839 SLPPPMLPSRVSGAVGGA 856
            .:.||::|:||.....||
Worm   807 GMYPPLIPTRVPTPSNGA 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	187/238 (79%)
		CrfC	73..>498	CDD:223771	315/424 (74%)
		Dynamin_M	212..498	CDD:279383	203/285 (71%)
		PH_dynamin	512..644	CDD:269958	71/131 (54%)
		PH	552..638	CDD:278594	55/85 (65%)
		GED	664..755	CDD:128597	60/90 (67%)
		DUF4527	<758..819	CDD:291689	21/60 (35%)
		Drf_FH1	<761..>846	CDD:283903	34/91 (37%)
dyn-1	NP_001024332.1	DLP_1	31..296	CDD:206738	219/264 (83%)
		CrfC	80..567	CDD:223771	347/507 (68%)
		Dynamin_M	219..505	CDD:279383	203/285 (71%)
		PH_dynamin	518..628	CDD:269958	71/131 (54%)
		PH	520..622	CDD:278594	63/123 (51%)
		GED	648..739	CDD:128597	60/90 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160046
Domainoid	1	1.000	420	1.000	Domainoid score	I321
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123905
Inparanoid	1	1.050	1084	1.000	Inparanoid score	I125
Isobase	1	0.950	-	0	Normalized mean entropy	S650
OMA	1	1.010	-	-		QHG52581
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	1	1.000	-	-		FOG0001563
OrthoInspector	1	1.000	-	-		oto19441
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	LDO	PTHR11566
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2499
SonicParanoid	1	1.000	-	-		X876
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890