DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment shi and DNM2

DIOPT Version :9

Sequence 1:NP_001259588.1 Gene:shi / 45928 FlyBaseID:FBgn0003392 Length:896 Species:Drosophila melanogaster
Sequence 2:NP_001005360.1 Gene:DNM2 / 1785 HGNCID:2974 Length:870 Species:Homo sapiens


Alignment Length:881 Identity:578/881 - (65%)
Similarity:684/881 - (77%) Gaps:62/881 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 65
            |:.||.:||||||||:|:|....|||||||||||||||||||||||||:||||||||||||||||
Human     6 MEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLI 70

  Fly    66 LQLINGVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLI 130
            ||||...||:.||||.|.|||:.|||:|:|||.|||||||:|||||.:|||||||||||||||||
Human    71 LQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLI 135

  Fly   131 DLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRT 195
            ||||:|||.:||||.|||.|||.||.|||.:|:.|||||||||.||||||||||||||||||:||
Human   136 DLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRT 200

  Fly   196 IGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSY 260
            ||||||||||||||||||:|||||||||||||||||||||||||:|||..|||||||||||||:|
Human   201 IGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAY 265

  Fly   261 RHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKAML 325
            ||||||:|||:||:.||||||||||::||.||.|||.|:|:|||||||:|:|:|.|.:.||||:|
Human   266 RHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALL 330

  Fly   326 QMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVKMACDEKELRREISFAIRN 390
            ||:||...|||:.|||||.. |:|.||||||:||||||||..||:|||..|||:||||||:||:|
Human   331 QMVQQFGVDFEKRIEGSGDQ-VDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKN 394

  Fly   391 IHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVRMCTAKMSRYPRLREETERI 455
            |||:|.||||||:|||||||:|:..||||.:||||||:|||...||.||:|:|.|||||||||||
Human   395 IHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYPRLREETERI 459

  Fly   456 ITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIGFANAQNKSENANKTGTRQLGNQ----VIR 516
            :||::|:||...|:|||||||.|.:|:||||||||||||||.:|...||  .|.:.||    |||
Human   460 VTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNK--KRAIPNQGEILVIR 522

  Fly   517 KGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLTSESISWYKDEDEKEKKFMLPLD 581
            :|.:.|.|:.:||                   |||:.||||||:||:||||||:|||||:|||||
Human   523 RGWLTINNISLMK-------------------GGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLD 568

  Fly   582 GLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKDYKQLELSCETVEDVESWKASFLRAGVYPEKQE 646
            .||:||:|:||  ||.:..||:|:.:.||||||.:|:||:|::.|||:|||||||||||||||.:
Human   569 NLKIRDVEKGF--MSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQ 631

  Fly   647 TQENGDESASEESSSDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLIINNAKDFINGEL 711
            . ||.|.:.....|.||||||||||||||||||:.|:.|:.||::||.||.|:|||.|.||:.||
Human   632 A-ENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHEL 695

  Fly   712 LAHLYASGDQAQMMEESAESATRREEMLRMYRACKDALQIIGDVSMATVSSPLPPPVKNDWLPSG 776
            ||:||:|.||:.:|||||:.|.||::|||||.|.|:||.||||:|.:|||:|:||||.:.||.|.
Human   696 LAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSA 760

  Fly   777 LDN---PRLSPPS-------PGGVRG-KPGPP-------AQSSLGGRNPPLPPSTGR-------- 815
            ..:   |:..|.|       |..||| .||||       |.:|...  ||:|...|.        
Human   761 SSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSA--PPIPSRPGPQSVFANSD 823

  Fly   816 --PA-PAIPNRPGGGAPPLPGGRPGGSLPPPMLPSR 848
              || |.||:||....|.:|.|.|  |..||..|||
Human   824 LFPAPPQIPSRPVRIPPGIPPGVP--SRRPPAAPSR 857

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shiNP_001259588.1 DYNc 1..240 CDD:197491 198/238 (83%)
CrfC 73..>498 CDD:223771 326/424 (77%)
Dynamin_M 212..498 CDD:279383 212/285 (74%)
PH_dynamin 512..644 CDD:269958 75/135 (56%)
PH 552..638 CDD:278594 56/85 (66%)
GED 664..755 CDD:128597 60/90 (67%)
DUF4527 <758..819 CDD:291689 30/89 (34%)
Drf_FH1 <761..>846 CDD:283903 40/113 (35%)
DNM2NP_001005360.1 DYNc 6..245 CDD:197491 198/238 (83%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 38..45 6/6 (100%)
G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 64..66 1/1 (100%)
G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 136..139 2/2 (100%)
G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 205..208 2/2 (100%)
Dynamin_M 216..502 CDD:395818 213/286 (74%)
G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 235..238 2/2 (100%)
PH_dynamin 520..629 CDD:269958 73/129 (57%)
GED 651..739 CDD:396682 57/87 (66%)
PHA03247 <737..868 CDD:223021 48/125 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 741..870 45/121 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 442 1.000 Domainoid score I542
eggNOG 1 0.900 - - E1_COG0699
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1133 1.000 Inparanoid score I221
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52581
OrthoDB 1 1.010 - - D141880at33208
OrthoFinder 1 1.000 - - FOG0001563
OrthoInspector 1 1.000 - - otm42088
orthoMCL 1 0.900 - - OOG6_100232
Panther 1 1.100 - - O PTHR11566
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X876
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.840

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