DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shi and drp-1

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_741403.2	Gene:	drp-1 / 177336	WormBaseID:	WBGene00001093	Length:	712	Species:	Caenorhabditis elegans

Alignment Length:	788	Identity:	299/788 - (37%)
Similarity:	434/788 - (55%)	Gaps:	115/788 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSLITIVNKLQDAFTSLG-VHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPL 64
            |::||.:||||||.|.:|| ...|:.||||.|||.|||||||||||.||:||||||:||||||||
Worm     1 MENLIPVVNKLQDVFATLGRKEDQIQLPQIVVVGSQSAGKSSVLENLVGRDFLPRGTGIVTRRPL 65

  Fly    65 ILQL-------------ING---VTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNI 113
            ||||             .||   ..::..|.|...|.|:.||.:|||||||||||||.|||||.:
Worm    66 ILQLNHVALDDESKRRRSNGTLLTDDWAMFEHTGSKVFTDFDAVRKEIEDETDRVTGVNKGISLL 130

  Fly   114 PINLRVYSPHVLNLTLIDLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLAN 178
            ||:|::||..|::|:|:||||:||:.:|||||:||:||::||..:|...:.:||||||||.|.|.
Worm   131 PISLKIYSHRVVSLSLVDLPGITKIPVGDQPVNIEEQIREMILLYISNPSSIILAVTPANQDFAT 195

  Fly   179 SDALKLAKEVDPQGVRTIGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDI 243
            |:.:|||:|||..|.||:.|:|||||||:||||.|:|..|::|::.|.||||||||::|...|.|
Worm   196 SEPIKLAREVDAGGQRTLAVLTKLDLMDQGTDAMDVLMGKVIPVKLGIIGVVNRSQQNILDNKLI 260

  Fly   244 HQALAAERKFFLSHPSYRHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKL-------QKQMLT 301
            ..|:..|:.|.  ...|..:|.|.|||||.:.||..|.:|||:.||.|:.::       |..::.
Worm   261 VDAVKDEQSFM--QKKYPTLASRNGTPYLAKRLNMLLMHHIRNCLPALKARVSIMNAQCQSDLVA 323

  Fly   302 LEKEVEEFKHFQPGDASIKTKAMLQMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERL 366
            ..:.||:           |.:.:||:|.:..:.:..||||: :..:.|.||.|||:|..|||:..
Worm   324 FGEPVED-----------KNRTLLQIITRFATAYTSTIEGT-ARNIETTELCGGARICYIFHDTF 376

  Fly   367 RFEIVKMACDEKELRREISFAIRNIHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQEL 431
            ...:..:...|...:.:|..||||..|.|..||.|:::||.:|||||..|:||.::||:||.:|:
Worm   377 GRSLESVNPLENLTQLDILTAIRNATGPRPALFVPEVSFELLVKRQIQRLEEPSLRCVELVHEEM 441

  Fly   432 SVVVRMC----TAKMSRYPRLREETERIITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIGF 492
            ..:|:.|    ..:|.|:|||.::...:::..:::|.....|.:..|:..||||:||.|.:|
Worm   442 QRMVQHCGFTTQQEMIRFPRLYDKINEVVSGVLKERLKPTNELVENLVAIELAYINTKHPEF--- 503

  Fly   493 ANAQNKSENANKTGTRQLGNQVIRKGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFV 557
                   ..||..        .:.|..:::       |.:.|||     |....|||
Worm   504 -------TEANLV--------TLLKEELLL-------DDRHGRS-----RNRHASTG-------- 533

  Fly   558 LTSESISWYKDEDEKEKKFMLPLDGLKLRDI-----EQGFMSMSRRVTFALFSPDGRNVYKDYKQ 617
              ..::|.:.::.      :.|:.|:...|:     :|...|.::|.:.......|.
Worm   534 --ERAVSAHGEQQ------LQPVPGVNGVDLNAVLQQQQQQSQNQRASNGFLGLFGN-------- 582

  Fly   618 LELSCETVEDVESWKASFLRAGVYPEKQETQENGDESASEESSSDPQLERQVETIRNLVDSYMKI 682
             ..:.......|...|:||     ||..||| .|.:..|.|       :|.|..|..|:.:|..|
Worm   583 -AAASSKTSPQEKQSANFL-----PEVPETQ-LGRKLTSRE-------QRDVAIIERLIRNYFII 633

  Fly   683 VTKTTRDMVPKAIMMLIINNAKDFINGELLAHLYASGDQAQMMEESAESATRREEMLRMYRACKD 747
            |.|..:|.||||||.|::|..:|.:..||:..||...:...::.|:.:.|.||.:.|...:|.:.
Worm   634 VRKNIQDSVPKAIMALLVNFVRDNLQSELVRQLYKPDEMDDLLAETEDMAQRRRDTLETMKALQQ 698

  Fly   748 ALQIIGDV 755
            |..||.:|
Worm   699 ASVIISEV 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	149/255 (58%)
		CrfC	73..>498	CDD:223771	183/435 (42%)
		Dynamin_M	212..498	CDD:279383	101/296 (34%)
		PH_dynamin	512..644	CDD:269958	22/136 (16%)
		PH	552..638	CDD:278594	12/90 (13%)
		GED	664..755	CDD:128597	31/90 (34%)
		DUF4527	<758..819	CDD:291689
		Drf_FH1	<761..>846	CDD:283903
drp-1	NP_741403.2	DLP_1	25..304	CDD:206738	155/280 (55%)
		CrfC	90..705	CDD:223771	245/696 (35%)
		Dynamin_M	229..503	CDD:279383	100/287 (35%)
		GED	618..706	CDD:280391	31/87 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820