DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shi and DNM1

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_001361198.1	Gene:	DNM1 / 1759	HGNCID:	2972	Length:	867	Species:	Homo sapiens

Alignment Length:	883	Identity:	586/883 - (66%)
Similarity:	693/883 - (78%)	Gaps:	74/883 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 65
            |:.||.:||:|||||:::|.:..|||||||||||||||||||||||||:|||||||||||||||:
Human     6 MEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLV 70

  Fly    66 LQLINGVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLI 130
            |||:|..|||.||||.|||||:.|:|:|.|||.|||||||:|||||.:||||||||||||||||:
Human    71 LQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLV 135

  Fly   131 DLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRT 195
            ||||:|||.:||||.|||.||:.|:.||:.||.||||||:|||:|||||||||:||||||||.||
Human   136 DLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRT 200

  Fly   196 IGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSY 260
            ||||||||||||||||||:|||||||||||||||||||||||:|:|||..|||||||||||||||
Human   201 IGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFFLSHPSY 265

  Fly   261 RHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKAML 325
            ||:|||:||||||:||||||||||||||||||:|||.|:|::||||||:|:|:|.|.:.||||:|
Human   266 RHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVEEYKNFRPDDPARKTKALL 330

  Fly   326 QMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVKMACDEKELRREISFAIRN 390
            ||:||...|||:.|||||.. ::|.||||||:||||||||..||:|||..||||||||||:||:|
Human   331 QMVQQFAVDFEKRIEGSGDQ-IDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAIKN 394

  Fly   391 IHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVRMCTAKMSRYPRLREETERI 455
            |||||.||||||||||.|||:|:..::||.:||||:|:.||...||.||.|:.:|||||||.|||
Human   395 IHGIRTGLFTPDMAFETIVKKQVKKIREPCLKCVDMVISELISTVRQCTKKLQQYPRLREEMERI 459

  Fly   456 ITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIGFANAQNKSENANKTGTRQLGNQ----VIR 516
            :|||:|:||...|||::||||.|||||||||||||||||||.:|...||..|.  |||    |||
Human   460 VTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTS--GNQDEILVIR 522

  Fly   517 KGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLTSESISWYKDEDEKEKKFMLPLD 581
            ||.:.|.|:||||                   |||:.||||||:|::|||||::|||||:||.:|
Human   523 KGWLTINNIGIMK-------------------GGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVD 568

  Fly   582 GLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKDYKQLELSCETVEDVESWKASFLRAGVYPEK-- 644
            .|||||:|:|||| |:.: ||||:.:.|||||||:||||:|||.|:|:||||||||||||||:
Human   569 NLKLRDVEKGFMS-SKHI-FALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAGVYPERVG 631

  Fly   645 -----QETQENGDESASEESSSDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLIINNAK 704
                 .||:|||.:|...  |.|||||||||||||||||||.||.||.||::||.||.|:|||.|
Human   632 DKEKASETEENGSDSFMH--SMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTK 694

  Fly   705 DFINGELLAHLYASGDQAQMMEESAESATRREEMLRMYRACKDALQIIGDVSMATVSSPLPPPVK 769
            :||..||||:||:.|||..:||||||.|.||:||||||.|.|:||.||||::..|||:|:||||.
Human   695 EFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVD 759

  Fly   770 NDWL-----PSGLDNPRLS----------PPSPGGVRG-KPG-PPAQSSLGGRNPPLPPSTGRPA 817
            :.||     |:|..:|..|          ||:..|.|| .|| |||.|:|||            |
Human   760 DSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPARPGSRGPAPGPPPAGSALGG------------A 812

  Fly   818 PAIPNRPGGGAPPLPGGRPGGSLPPPMLPSRVSGAVGG 855
            |.:|:||  ||.|.|.|      |||.:|||.:.|..|
Human   813 PPVPSRP--GASPDPFG------PPPQVPSRPNRAPPG 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	191/238 (80%)
		CrfC	73..>498	CDD:223771	324/424 (76%)
		Dynamin_M	212..498	CDD:279383	213/285 (75%)
		PH_dynamin	512..644	CDD:269958	80/135 (59%)
		PH	552..638	CDD:278594	58/85 (68%)
		GED	664..755	CDD:128597	65/90 (72%)
		DUF4527	<758..819	CDD:291689	29/77 (38%)
		Drf_FH1	<761..>846	CDD:283903	39/101 (39%)
DNM1	NP_001361198.1	DYNc	6..245	CDD:197491	191/238 (80%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	38..45		6/6 (100%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	64..66		1/1 (100%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	136..139		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	205..208		2/2 (100%)
		Dynamin_M	216..502	CDD:395818	214/286 (75%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	235..238		2/2 (100%)
		PH_dynamin	520..629	CDD:269958	78/129 (60%)
		GED	657..745	CDD:396682	62/87 (71%)
		PHA03247	<747..852	CDD:223021	46/116 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	442	1.000	Domainoid score	I542
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123905
Inparanoid	1	1.050	1133	1.000	Inparanoid score	I221
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52581
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	1	1.000	-	-		FOG0001563
OrthoInspector	1	1.000	-	-		otm42088
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	LDO	PTHR11566
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2499
SonicParanoid	1	1.000	-	-		X876
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870