Protein Alignment shi and DNM1

DIOPT Version :10

• Sequence 1: NP_001259588.1
• Gene: shi / 45928
• FlyBaseID: FBgn0003392
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: NP_001361198.1
• Gene: DNM1 / 1759
• HGNCID: 2972
• Length: 867
• Species: Homo sapiens
• Alignment Length: 883
• Identity: 586/883 - (66%)
• Similarity: 693/883 - (78%)
• Gaps: 74/883 - (8%)

  Fly     1 MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 65
            |:.||.:||:|||||:::|.:..|||||||||||||||||||||||||:|||||||||||||||:
Human     6 MEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLV 70

  Fly    66 LQLINGVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLI 130
            |||:|..|||.||||.|||||:.|:|:|.|||.|||||||:|||||.:||||||||||||||||:
Human    71 LQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLV 135

  Fly   131 DLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRT 195
            ||||:|||.:||||.|||.||:.|:.||:.||.||||||:|||:|||||||||:||||||||.||
Human   136 DLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRT 200

  Fly   196 IGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSY 260
            ||||||||||||||||||:|||||||||||||||||||||||:|:|||..|||||||||||||||
Human   201 IGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFFLSHPSY 265

  Fly   261 RHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKAML 325
            ||:|||:||||||:||||||||||||||||||:|||.|:|::||||||:|:|:|.|.:.||||:|
Human   266 RHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVEEYKNFRPDDPARKTKALL 330

  Fly   326 QMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVKMACDEKELRREISFAIRN 390
            ||:||...|||:.|||||.. ::|.||||||:||||||||..||:|||..||||||||||:||:|
Human   331 QMVQQFAVDFEKRIEGSGDQ-IDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAIKN 394

  Fly   391 IHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVRMCTAKMSRYPRLREETERI 455
            |||||.||||||||||.|||:|:..::||.:||||:|:.||...||.||.|:.:|||||||.|||
Human   395 IHGIRTGLFTPDMAFETIVKKQVKKIREPCLKCVDMVISELISTVRQCTKKLQQYPRLREEMERI 459

  Fly   456 ITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIGFANAQNKSENANKTGTRQLGNQ----VIR 516
            :|||:|:||...|||::||||.|||||||||||||||||||.:|...||..|.  |||    |||
Human   460 VTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTS--GNQDEILVIR 522

  Fly   517 KGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLTSESISWYKDEDEKEKKFMLPLD 581
            ||.:.|.|:||||                   |||:.||||||:|::|||||::|||||:||.:|
Human   523 KGWLTINNIGIMK-------------------GGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVD 568

  Fly   582 GLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKDYKQLELSCETVEDVESWKASFLRAGVYPEK-- 644
            .|||||:|:|||| |:.: ||||:.:.|||||||:||||:|||.|:|:||||||||||||||:
Human   569 NLKLRDVEKGFMS-SKHI-FALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAGVYPERVG 631

  Fly   645 -----QETQENGDESASEESSSDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLIINNAK 704
                 .||:|||.:|...  |.|||||||||||||||||||.||.||.||::||.||.|:|||.|
Human   632 DKEKASETEENGSDSFMH--SMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTK 694

  Fly   705 DFINGELLAHLYASGDQAQMMEESAESATRREEMLRMYRACKDALQIIGDVSMATVSSPLPPPVK 769
            :||..||||:||:.|||..:||||||.|.||:||||||.|.|:||.||||::..|||:|:||||.
Human   695 EFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVD 759

  Fly   770 NDWL-----PSGLDNPRLS----------PPSPGGVRG-KPG-PPAQSSLGGRNPPLPPSTGRPA 817
            :.||     |:|..:|..|          ||:..|.|| .|| |||.|:|||            |
Human   760 DSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPARPGSRGPAPGPPPAGSALGG------------A 812

  Fly   818 PAIPNRPGGGAPPLPGGRPGGSLPPPMLPSRVSGAVGG 855
            |.:|:||  ||.|.|.|      |||.:|||.:.|..|
Human   813 PPVPSRP--GASPDPFG------PPPQVPSRPNRAPPG 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	191/238 (80%)
		Dynamin_M	210..498	CDD:460033	215/287 (75%)
		PH_dynamin	512..644	CDD:269958	80/135 (59%)
		GED	664..755	CDD:128597	65/90 (72%)
		FAP	725..>855	CDD:429334	68/146 (47%)
DNM1	NP_001361198.1	DYNc	6..245	CDD:197491	191/238 (80%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	38..45		6/6 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	64..66		1/1 (100%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	136..139		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	205..208		2/2 (100%)
		Dynamin_M	215..502	CDD:460033	215/287 (75%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	235..238		2/2 (100%)
		PH_dynamin	520..629	CDD:269958	78/129 (60%)
		GED	655..745	CDD:460495	64/89 (72%)
		PHA03247	<747..852	CDD:223021	46/116 (40%)