Protein Alignment shi and fzo-1

DIOPT Version :10

• Sequence 1: NP_001259588.1
• Gene: shi / 45928
• FlyBaseID: FBgn0003392
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: NP_495161.1
• Gene: fzo-1 / 173990
• WormBaseID: WBGene00001509
• Length: 774
• Species: Caenorhabditis elegans
• Alignment Length: 615
• Identity: 120/615 - (19%)
• Similarity: 207/615 - (33%)
• Gaps: 231/615 - (37%)

  Fly     2 DSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLIL 66
            ||:.||:    |.|       |.|..::...|..|.|||:.:...:.:..||:|.|..|  ...|
 Worm    87 DSIKTIM----DTF-------QRDNMKVVFFGRTSNGKSTTINAMLHEKVLPQGMGHTT--CCFL 138

  Fly    67 QLINGVTEYGEF----------LHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPIN----- 116
            |:.....|.|..          :.:.||       |...:.||.          |::|..
 Worm   139 QVEGSEGEVGHLQLDDNPQKIDMKMLGK-------IGHALSDEN----------SDLPAMGQDSL 186

  Fly   117 LRVYSP--------HVL--NLTLIDLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCL----IL 167
            |:|:.|        .:|  ::.::|.||          ||:..:....|     .:.||    .:
 Worm   187 LKVFHPKKSESGECRLLQNDVVILDSPG----------VDLSPEFDSWI-----DKHCLDADVFV 236

  Fly   168 AVTPANTDLANSDA---LKLAKEVDPQGVRTIG---------------------------VITKL 202
            .|:.|.:.|..::.   |::||::....|..:.                           ::.:|
 Worm   237 LVSNAESTLTQAEKNFFLRVAKKLSKPNVFILNNRWDASAAETENIEDVKKQHLTRFRQFLVDEL 301

  Fly   203 DLMDEG--------TDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPS 259
            ::..|.        ..:|::||::|...     |:|.::.: .||    |...|.|.:.|..|
 Worm   302 EVCSEREVNDRIFFVSSREVLESRLKAR-----GLVQKAYQ-AEG----HGTRALEFQNFERH-- 354

  Fly   260 YRHMADR--LGTPY-------------LQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEE- 308
            :.|...|  :.|.:             ::..||..||:....     |.|||..:....:...|
 Worm   355 FEHCISRSAIHTKFEAHNRRAHEMIGKMRLNLNSVLTSAAEQ-----RSKLQNNLNESTRTFNEC 414

  Fly   309 ---FKHFQPGDASIKTKAMLQMIQQLQSD----------------------FERTIEGSGSALVN 348
               |..|:        ||..:..:||:::                      ||:..:||.|.:..
 Worm   415 RVNFTQFE--------KAYREQTEQLRAEVHLKVSADFFEEIARLDAIIDRFEQPFDGSSSGMTK 471

  Fly   349 TNE---------LSG-------GAKINRIFH-ERLRFEIVKMACDEK---------ELRREISFA 387
            ..|         ||.       |..::||:: |...|:.|.....|.         ..|....|:
 Worm   472 YKEDLAIFVDKCLSSDLEARCTGGLMSRIWNLENDMFQYVTKILAEPYQNKLEEVWRYRAPFKFS 536

  Fly   388 IRNIHGIRVGLFTPDMAF------EAIVKRQIALLK-EPVIKCVDLVVQELSVVVRMCTAKMSRY 445
            |.......|..|..|:.|      .||::|.||... :||......::..||
 Worm   537 ICVDVPALVNDFHEDLEFRFTFGLHAIIRRIIAYRSGQPVTAINTNLLTPLS------------- 588

  Fly   446 PRLREETERIITTHVRQREHSC--KEQILL 473
              |::::|:   ..||..|.|.  :||.::
 Worm   589 --LKQQSEK---NSVRDAEASAASEEQAMM 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	57/304 (19%)
		Dynamin_M	210..498	CDD:460033	70/340 (21%)
		PH_dynamin	512..644	CDD:269958
		GED	664..755	CDD:128597
		FAP	725..>855	CDD:429334
fzo-1	NP_495161.1	P-loop containing Nucleoside Triphosphate Hydrolases	<70..>123	CDD:476819	13/46 (28%)
		DLP_2	101..359	CDD:206739	56/303 (18%)
		Fzo_mitofusin	609..767	CDD:461432	2/5 (40%)