DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shi and Dnm3

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_017454151.1	Gene:	Dnm3 / 171574	RGDID:	727949	Length:	873	Species:	Rattus norvegicus

Alignment Length:	880	Identity:	573/880 - (65%)
Similarity:	676/880 - (76%)	Gaps:	68/880 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 65
            |:.||.:||:|||||::||....|:|||||||||||||||||||||||:|||||||||||||||:
  Rat     6 MEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLV 70

  Fly    66 LQLINGVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLI 130
            |||:....||.||||.|||||:.|||:|.|||.|||||||.|||||::|||||||||||||||||
  Rat    71 LQLVTSKAEYAEFLHCKGKKFTDFDEVRHEIEAETDRVTGMNKGISSVPINLRVYSPHVLNLTLI 135

  Fly   131 DLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRT 195
            ||||:|||.:||||.|||.||:.||.|||.:|.|||||||||||||||||||||||||||||:||
  Rat   136 DLPGITKVPVGDQPPDIEYQIRDMIMQFITRENCLILAVTPANTDLANSDALKLAKEVDPQGLRT 200

  Fly   196 IGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSY 260
            ||||||||||||||||||:||||||||||||:||||||||||:|:|||..|:.||||||||||:|
  Rat   201 IGVITKLDLMDEGTDARDVLENKLLPLRRGYVGVVNRSQKDIDGKKDIKAAMLAERKFFLSHPAY 265

  Fly   261 RHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKAML 325
            ||:|||:|||:||:|||||||||||||||..|:|||.|:|::|.|||.||:|:|.|.:.||||:|
  Rat   266 RHIADRMGTPHLQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEVEAFKNFKPEDPTRKTKALL 330

  Fly   326 QMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVKMACDEKELRREISFAIRN 390
            ||:||...|||:.|||||.. |:|.|||||||||||||||..||||||..:|||||||||:||:|
  Rat   331 QMVQQFAVDFEKRIEGSGDQ-VDTLELSGGAKINRIFHERFPFEIVKMEFNEKELRREISYAIKN 394

  Fly   391 IHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVRMCTAKMSRYPRLREETERI 455
            |||||.||||||||||||||:||..||.|.:|.||||:|||...|:.||.:::.:|||.||||||
  Rat   395 IHGIRTGLFTPDMAFEAIVKKQIVKLKGPSLKSVDLVMQELINTVKKCTKRLANFPRLCEETERI 459

  Fly   456 ITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIGFANAQNKSENANKTGTRQLGNQ------- 513
            :..|:|:||...|:|:|||||.:::|:||||||||||||||.:|...:|..|  :|||
  Rat   460 VANHIREREGKTKDQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHKKST--IGNQGTNLPPS 522

  Fly   514 ---VIRKGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLTSESISWYKDEDEKEKK 575
               |||||.:.:.|:||||                   |||:.||||||:||:|||||::|||||
  Rat   523 RQIVIRKGWLTVSNIGIMK-------------------GGSKGYWFVLTAESLSWYKDDEEKEKK 568

  Fly   576 FMLPLDGLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKDYKQLELSCETVEDVESWKASFLRAGV 640
            :|||||.||:||:|:|||| |:.| ||||:.:.|||||||:.|||:|::.|||:|||||.|||||
  Rat   569 YMLPLDNLKVRDVEKGFMS-SKHV-FALFNTEQRNVYKDYRSLELACDSQEDVDSWKASLLRAGV 631

  Fly   641 YPEKQ------ETQENGDESASEESSSDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLI 699
            ||:|.      |..|||.   :|..|.|||||||||||||||||||.|:.|..||::||.||.|:
  Rat   632 YPDKSFGSNKTENDENGQ---AENFSMDPQLERQVETIRNLVDSYMSIINKCIRDLIPKTIMHLM 693

  Fly   700 INNAKDFINGELLAHLYASGDQAQMMEESAESATRREEMLRMYRACKDALQIIGDVSMATVSSPL 764
            |||.|||||.||||.||:|.||..:||||.|.|.||:||||||:|.|:||.||||::..|||:|.
  Rat   694 INNVKDFINSELLAQLYSSEDQNTLMEESVEQAQRRDEMLRMYQALKEALAIIGDINTVTVSTPA 758

  Fly   765 PPPVKNDWLPSGLDNPRLSPPSPGGVRGKPGPPAQSSLGGRNP-PLPPSTGRPAPAIPN-RPGGG 827
            ||||.:.|    |.:.|.|||        |.|..|..|....| |.|.|:..||||||: .|..|
  Rat   759 PPPVDDSW----LQHSRRSPP--------PSPTTQRRLTLSAPLPRPASSRGPAPAIPSPGPHSG 811

  Fly   828 APPLPGGRPGGSLP----------PPMLPSRVSGA 852
            |||:| .|||...|          ||.:|||.:.|
  Rat   812 APPVP-FRPGPLPPFPNSSDSYGAPPQVPSRPTRA 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	194/238 (82%)
		CrfC	73..>498	CDD:223771	318/424 (75%)
		Dynamin_M	212..498	CDD:279383	202/285 (71%)
		PH_dynamin	512..644	CDD:269958	79/141 (56%)
		PH	552..638	CDD:278594	58/85 (68%)
		GED	664..755	CDD:128597	64/90 (71%)
		DUF4527	<758..819	CDD:291689	24/61 (39%)
		Drf_FH1	<761..>846	CDD:283903	38/96 (40%)
Dnm3	XP_017454151.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	441	1.000	Domainoid score	I523
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1133	1.000	Inparanoid score	I209
OMA	1	1.010	-	-		QHG52581
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	1	1.000	-	-		FOG0001563
OrthoInspector	1	1.000	-	-		otm46234
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X876
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880