DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shi and Dnm1

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_038960068.1	Gene:	Dnm1 / 140694	RGDID:	71096	Length:	868	Species:	Rattus norvegicus

Alignment Length:	900	Identity:	589/900 - (65%)
Similarity:	701/900 - (77%)	Gaps:	74/900 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 65
            |:.||.:||:|||||:::|.:..|||||||||||||||||||||||||:|||||||||||||||:
  Rat     6 MEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLV 70

  Fly    66 LQLINGVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLI 130
            |||:|..|||.||||.|||||:.|:|:|.|||.|||||||:|||||.:||||||||||||||||:
  Rat    71 LQLVNSTTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLV 135

  Fly   131 DLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRT 195
            ||||:|||.:||||.|||.||:.|:.||:.||.||||||:|||:|||||||||:||||||||.||
  Rat   136 DLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKIAKEVDPQGQRT 200

  Fly   196 IGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSY 260
            ||||||||||||||||||:|||||||||||||||||||||||:|:|||..|||||||||||||||
  Rat   201 IGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAERKFFLSHPSY 265

  Fly   261 RHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKAML 325
            ||:|||:||||||:||||||||||||||||||:|||.|:|::||||:|:|:|:|.|.:.||||:|
  Rat   266 RHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVDEYKNFRPDDPARKTKALL 330

  Fly   326 QMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVKMACDEKELRREISFAIRN 390
            ||:||...|||:.|||||.. ::|.||||||:||||||||..||:|||..||||||||||:||:|
  Rat   331 QMVQQFAVDFEKRIEGSGDQ-IDTYELSGGARINRIFHERFPFELVKMEFDEKELRREISYAIKN 394

  Fly   391 IHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVRMCTAKMSRYPRLREETERI 455
            |||||.||||||:||||.||:|:..||||.|||||:||.||:..:|.|:.|:.:|||||||.|||
  Rat   395 IHGIRTGLFTPDLAFEATVKKQVQKLKEPSIKCVDMVVSELTSTIRKCSEKLQQYPRLREEMERI 459

  Fly   456 ITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIGFANAQNKSENANKTGTRQLGNQ----VIR 516
            :|||:|:||...|||::||||.|||||||||||||||||||.:|...||..|.  |||    |||
  Rat   460 VTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQRSNQMNKKKTS--GNQDEILVIR 522

  Fly   517 KGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLTSESISWYKDEDEKEKKFMLPLD 581
            ||.:.|.|:||||                   |||:.||||||:|::|||||::|||||:||.:|
  Rat   523 KGWLTINNIGIMK-------------------GGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVD 568

  Fly   582 GLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKDYKQLELSCETVEDVESWKASFLRAGVYPEK-- 644
            .|||||:|:|||| |:.: ||||:.:.|||||||:||||:|||.|:|:||||||||||||||:
  Rat   569 NLKLRDVEKGFMS-SKHI-FALFNTEQRNVYKDYRQLELACETQEEVDSWKASFLRAGVYPERVG 631

  Fly   645 -----QETQENGDESASEESSSDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLIINNAK 704
                 .||:|||.:|...  |.|||||||||||||||||||.||.||.||::||.||.|:|||.|
  Rat   632 DKEKASETEENGSDSFMH--SMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTK 694

  Fly   705 DFINGELLAHLYASGDQAQMMEESAESATRREEMLRMYRACKDALQIIGDVSMATVSSPLPPPVK 769
            :||..||||:||:.|||..:||||||.|.||:||||||.|.|:||.||||::..|||:|:||||.
  Rat   695 EFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVD 759

  Fly   770 NDWL-----PSGLDNPRLS----------PPSPGGVRG-KPG-PPAQSSLGGRNPPLPPSTGRPA 817
            :.||     |:|..:|..|          ||:..|.|| .|| |||.|:|||            |
  Rat   760 DSWLQVQSVPAGRRSPTSSPTPQRRAPAVPPARPGSRGPAPGPPPAGSALGG------------A 812

  Fly   818 PAIPNRPGGGAPPLPGGRPGGSLPPPMLPSRVSGAVGGAIVQQSGANRYVPESMR 872
            |.:|:||  ||.|.|.|      |||.:|||.:.|..|...::..|:...|.:.|
  Rat   813 PPVPSRP--GASPDPFG------PPPQVPSRPNRAPPGVPSRKGPASPTRPAAPR 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	191/238 (80%)
		CrfC	73..>498	CDD:223771	324/424 (76%)
		Dynamin_M	212..498	CDD:279383	213/285 (75%)
		PH_dynamin	512..644	CDD:269958	80/135 (59%)
		PH	552..638	CDD:278594	58/85 (68%)
		GED	664..755	CDD:128597	65/90 (72%)
		DUF4527	<758..819	CDD:291689	29/77 (38%)
		Drf_FH1	<761..>846	CDD:283903	39/101 (39%)
Dnm1	XP_038960068.1	DYNc	6..245	CDD:197491	191/238 (80%)
		Dynamin_M	216..502	CDD:395818	214/286 (75%)
		PH_dynamin	520..629	CDD:269958	78/129 (60%)
		GED	657..745	CDD:396682	62/87 (71%)
		PHA03247	<747..864	CDD:223021	48/132 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	441	1.000	Domainoid score	I523
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123905
Inparanoid	1	1.050	1133	1.000	Inparanoid score	I209
OMA	1	1.010	-	-		QHG52581
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	1	1.000	-	-		FOG0001563
OrthoInspector	1	1.000	-	-		otm46234
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	LDO	PTHR11566
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X876
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.980