DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shi and Dnm2

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_006510036.1	Gene:	Dnm2 / 13430	MGIID:	109547	Length:	880	Species:	Mus musculus

Alignment Length:	891	Identity:	578/891 - (64%)
Similarity:	682/891 - (76%)	Gaps:	72/891 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 65
            |:.||.:||||||||:|:|....|||||||||||||||||||||||||:||||||||||||||||
Mouse     6 MEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLI 70

  Fly    66 LQLINGVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLI 130
            ||||...|||.||||.|.|||:.|||:|:|||.|||||||:|||||.:|||||||||||||||||
Mouse    71 LQLIFSKTEYAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLI 135

  Fly   131 DLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRT 195
            ||||:|||.:||||.|||.|||.||.|||.:|:.|||||||||.||||||||||||||||||:||
Mouse   136 DLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRT 200

  Fly   196 IGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSY 260
            ||||||||||||||||||:|||||||||||||||||||||||||:|||..|||||||||||||:|
Mouse   201 IGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAY 265

  Fly   261 RHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKAML 325
            ||||||:|||:||:.||||||||||::||.||.|||.|:|:|||||||:|:|:|.|.:.||||:|
Mouse   266 RHMADRMGTPHLQKTLNQQLTNHIRESLPTLRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALL 330

  Fly   326 QMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVKMACDEKELRREISFAIRN 390
            ||:||...|||:.|||||.. |:|.||||||:||||||||..||:|||..|||:||||||:||:|
Mouse   331 QMVQQFGVDFEKRIEGSGDQ-VDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKN 394

  Fly   391 IHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVRMCTAKMSRYPRLREETERI 455
            |||:|.||||||:|||||||:|:..||||.:||||||:|||...||.||:|:|.|||||||||||
Mouse   395 IHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELISTVRQCTSKLSSYPRLREETERI 459

  Fly   456 ITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIGFAN----------AQNKSENANKTGTRQL 510
            :||::|:||...|:|||||||.|.:|:||||||||||||          ||.:|...||  .|.:
Mouse   460 VTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANCFYTEELVTGAQQRSTQLNK--KRAI 522

  Fly   511 GNQ----VIRKGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLTSESISWYKDEDE 571
            .||    |||:|.:.|.|:.:||                   |||:.||||||:||:||||||:|
Mouse   523 PNQGEILVIRRGWLTINNISLMK-------------------GGSKEYWFVLTAESLSWYKDEEE 568

  Fly   572 KEKKFMLPLDGLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKDYKQLELSCETVEDVESWKASFL 636
            ||||:|||||.||:||:|:||  ||.:..||:|:.:.||||||.:|:||:|::.|||:|||||||
Mouse   569 KEKKYMLPLDNLKIRDVEKGF--MSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFL 631

  Fly   637 RAGVYPEKQETQENGDESASEESSSDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLIIN 701
            ||||||||.:. ||.|.:.....|.||||||||||||||||||:.|:.|:.||::||.||.|:||
Mouse   632 RAGVYPEKDQA-ENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMIN 695

  Fly   702 NAKDFINGELLAHLYASGDQAQMMEESAESATRREEMLRMYRACKDALQIIGDVSMATVSSPLPP 766
            |.|.||:.||||:||:|.||:.:||||||.|.||::|||||.|.|:||.||||:|.:|||:|:||
Mouse   696 NTKAFIHHELLAYLYSSADQSSLMEESAEQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPP 760

  Fly   767 PVKNDWL-------PSGLDNP--RLSPPS-PGGVRG-KPGPP-------AQSSLGGRNPPLPPST 813
            ||.:.||       |:....|  .:.||. |..||| .||||       |.||...  ||:|...
Mouse   761 PVDDTWLQNTSGHSPTPQRRPVSSVHPPGRPPAVRGPTPGPPLIPMPVGATSSFSA--PPIPSRP 823

  Fly   814 GRPA-----------PAIPNRPGGGAPPLPGGRPGGSLPPPMLPSR 848
            |..:           |.||:||....|.:|.|.|  |...|..|||
Mouse   824 GPQSVFANNDPFSAPPQIPSRPARIPPGIPPGVP--SRRAPAAPSR 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	199/238 (84%)
		CrfC	73..>498	CDD:223771	327/434 (75%)
		Dynamin_M	212..498	CDD:279383	212/295 (72%)
		PH_dynamin	512..644	CDD:269958	75/135 (56%)
		PH	552..638	CDD:278594	56/85 (66%)
		GED	664..755	CDD:128597	61/90 (68%)
		DUF4527	<758..819	CDD:291689	29/89 (33%)
		Drf_FH1	<761..>846	CDD:283903	38/113 (34%)
Dnm2	XP_006510036.1	DYNc	6..245	CDD:197491	199/238 (84%)
		Dynamin_M	216..498	CDD:366427	209/282 (74%)
		PH_dynamin	530..639	CDD:269958	73/129 (57%)
		GED	660..749	CDD:366984	59/88 (67%)
		PHA03247	<747..878	CDD:223021	46/125 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	441	1.000	Domainoid score	I540
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1128	1.000	Inparanoid score	I223
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52581
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	1	1.000	-	-		FOG0001563
OrthoInspector	1	1.000	-	-		otm44141
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2499
SonicParanoid	1	1.000	-	-		X876
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870