DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shi and Dnm1l

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_038943816.1	Gene:	Dnm1l / 114114	RGDID:	620416	Length:	761	Species:	Rattus norvegicus

Alignment Length:	819	Identity:	302/819 - (36%)
Similarity:	446/819 - (54%)	Gaps:	128/819 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 65
            |::||.::|||||.|.::|..: :.||||.|||.||:|||||||:.||:|.||||:|:|||||||
  Rat     1 MEALIPVINKLQDVFNTVGADI-IQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGVVTRRPLI 64

  Fly    66 LQLI--------------NG---------------------VTEYGEFLHIKGKKFSSFDEIRKE 95
            |||:              ||                     ..|:|:|||.|.|.::.|||||:|
  Rat    65 LQLVHVSPEDKRKTTGEENGKFQSWNPATWKNSRHLSKGVEAEEWGKFLHTKNKLYTDFDEIRQE 129

  Fly    96 IEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLIDLPGLTKVAIGDQPVDIEQQIKQMIFQFIR 160
            ||:||:|::|:|||:|..||:|:|:||:|:||||:||||:|||.:||||.|||.||:::|.:||.
  Rat   130 IENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFIS 194

  Fly   161 KETCLILAVTPANTDLANSDALKLAKEVDPQGVRTIGVITKLDLMDEGTDARDILENKLLPLRRG 225
            ....:|||||.||||:|.|:|||:::||||.|.||:.|||||||||.||||.|:|..:::|::.|
  Rat   195 NPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLG 259

  Fly   226 YIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSYRHMADRLGTPYLQRVLNQQLTNHIRDTLPG 290
            .||||||||.||..:|.:..::..|..|.  ...|..:|:|.||.||.|.||:.|.:||||.||.
  Rat   260 IIGVVNRSQLDINNKKSVTDSIRDEYAFL--QKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPE 322

  Fly   291 LRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKAMLQMIQQLQSDFERTIEGSGSALVNTNELSGG 355
            |:.::  .:|..:.:.....:.:|.|.  |:..:||:|.:..:::..||||: :..:.|:||.||
  Rat   323 LKTRI--NVLAAQYQSLLNSYGEPVDD--KSATLLQLITKFATEYCNTIEGT-AKYIETSELCGG 382

  Fly   356 AKINRIFHERL--RFEIVKMACDEKELRREISFAIRNIHGIRVGLFTPDMAFEAIVKRQIALLKE 418
            |:|..||||..  ..|.|........:  :|..||||..|.|..||.|:::||.:|||||..|:|
  Rat   383 ARICYIFHETFGRTLESVDPLGGLNTI--DILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEE 445

  Fly   419 PVIKCVDLVVQELSVVVRMC----TAKMSRYPRLREETERIITTHVRQREHSCKEQILLLIDFEL 479
            |.::||:||.:|:..:::.|    |.::.|:|:|.:....::|..:|:|.....|.:..|:..||
  Rat   446 PSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIEL 510

  Fly   480 AYMNTNHEDF---IGFANAQNKSENANKTGTRQLGNQVIRKGHMVIQNLGIMKDIKLGRSGPLNV 541
            ||:||.|.||   .|..|...:.:..|:. .|:|.:.|.|.           |..|:..:
  Rat   511 AYINTKHPDFADACGLMNNNIEEQRRNRL-ARELPSAVSRD-----------KSSKVPSA----- 558

  Fly   542 RFFSPSTGGSRPYWFVLTSESISWYKDEDEKEKKFMLPLDGLKLRDIEQGFMSMSRRVTFALFSP 606
              .:|::....|   ..::|:                  ||..::|        :||.|..:.|.
  Rat   559 --LAPASQEPSP---AASAEA------------------DGKLIQD--------NRRETKNVASA 592

  Fly   607 DG--------------------RNVYKDYKQLELSCETVEDVESWKASFLRAGVYPEKQETQENG 651
            .|                    |.:.|..|..||..|.    :|.....:.|.  |:|.......
  Rat   593 GGGIGDGGRIGDGGQEPTTGNWRGMLKTSKAEELLAEE----KSKPIPIMPAS--PQKGHAVNLL 651

  Fly   652 DESASEESSSDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLIINNAKDFINGELLAHLY 716
            |...........:.:|..|.|..|:.||..||.|..:|.||||:|..::|:.||.:..||:..||
  Rat   652 DVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLY 716

  Fly   717 ASGDQAQMMEESAESATRREEMLRMYRACKDALQIIGDV 755
            .|.....::.||.:.|.||:|...|.:|.:.|.|||.::
  Rat   717 KSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEI 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	147/273 (54%)
		CrfC	73..>498	CDD:223771	192/433 (44%)
		Dynamin_M	212..498	CDD:279383	105/294 (36%)
		PH_dynamin	512..644	CDD:269958	24/151 (16%)
		PH	552..638	CDD:278594	17/105 (16%)
		GED	664..755	CDD:128597	35/90 (39%)
		DUF4527	<758..819	CDD:291689
		Drf_FH1	<761..>846	CDD:283903
Dnm1l	XP_038943816.1	DLP_1	23..321	CDD:206738	155/299 (52%)
		Dynamin_M	245..529	CDD:395818	105/292 (36%)
		GED	667..755	CDD:396682	35/87 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820