DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shi and Dnm3

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_006496664.1	Gene:	Dnm3 / 103967	MGIID:	1341299	Length:	873	Species:	Mus musculus

Alignment Length:	881	Identity:	578/881 - (65%)
Similarity:	682/881 - (77%)	Gaps:	70/881 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 65
            |:.||.:||:|||||::||....|:|||||||||||||||||||||||:|||||||||||||||:
Mouse     6 MEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLV 70

  Fly    66 LQLINGVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLI 130
            |||:....||.||||.|||||:.|||:|.|||.|||||||.|||||:||||||||||||||||||
Mouse    71 LQLVTSKAEYAEFLHCKGKKFTDFDEVRHEIEAETDRVTGMNKGISSIPINLRVYSPHVLNLTLI 135

  Fly   131 DLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRT 195
            ||||:|||.:||||.|||.||:.||.|||.:|.|||||||||||||||||||||||||||||:||
Mouse   136 DLPGITKVPVGDQPPDIEYQIRDMIMQFITRENCLILAVTPANTDLANSDALKLAKEVDPQGLRT 200

  Fly   196 IGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSY 260
            ||||||||||||||||||:||||||||||||:||||||||||:|:|||..|:.||||||||||:|
Mouse   201 IGVITKLDLMDEGTDARDVLENKLLPLRRGYVGVVNRSQKDIDGKKDIKAAMLAERKFFLSHPAY 265

  Fly   261 RHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKAML 325
            ||:|||:|||:||:|||||||||||||||..|:|||.|:|::|.|||.||:|:|.|.:.||||:|
Mouse   266 RHIADRMGTPHLQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEVEAFKNFKPEDPTRKTKALL 330

  Fly   326 QMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVKMACDEKELRREISFAIRN 390
            ||:||...|||:.|||||.. |:|.|||||||||||||||..||||||..:|||||||||:||:|
Mouse   331 QMVQQFAVDFEKRIEGSGDQ-VDTLELSGGAKINRIFHERFPFEIVKMEFNEKELRREISYAIKN 394

  Fly   391 IHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVRMCTAKMSRYPRLREETERI 455
            |||||.||||||||||||||:||..||.|.:|.||||:|||...|:.||.:::.:|||.||||||
Mouse   395 IHGIRTGLFTPDMAFEAIVKKQIVKLKGPSLKSVDLVMQELINTVKKCTKRLANFPRLCEETERI 459

  Fly   456 ITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIGFANAQNKSENANKTGTRQLGNQ------- 513
            :..|:|:||...|:|:|||||.:::|:||||||||||||||.:|...:|..|  :|||
Mouse   460 VANHIREREGKTKDQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQVHKKST--IGNQGTNLPPS 522

  Fly   514 ---VIRKGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLTSESISWYKDEDEKEKK 575
               |||||.:.:.|:||||                   |||:.||||||:||:|||||::|||||
Mouse   523 RQIVIRKGWLTVSNIGIMK-------------------GGSKGYWFVLTAESLSWYKDDEEKEKK 568

  Fly   576 FMLPLDGLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKDYKQLELSCETVEDVESWKASFLRAGV 640
            :|||||.||:||:|:|||| |:.| ||||:.:.|||||||:.|||:|::.|||:|||||.|||||
Mouse   569 YMLPLDNLKVRDVEKGFMS-SKHV-FALFNTEQRNVYKDYRFLELACDSQEDVDSWKASLLRAGV 631

  Fly   641 YPEKQ------ETQENGDESASEESSSDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLI 699
            ||:|.      |..|||.   :|..|.|||||||||||||||||||.|:.|..||::||.||.|:
Mouse   632 YPDKSVGSNKTENDENGQ---AENFSMDPQLERQVETIRNLVDSYMSIINKCIRDLIPKTIMHLM 693

  Fly   700 INNAKDFINGELLAHLYASGDQAQMMEESAESATRREEMLRMYRACKDALQIIGDVSMATVSSPL 764
            |||.|||||.||||.||:|.||..:||||||.|.||:||||||:|.|:||.||||::.||||:|.
Mouse   694 INNVKDFINSELLAQLYSSEDQNTLMEESAEQAQRRDEMLRMYQALKEALAIIGDINTATVSTPA 758

  Fly   765 PPPVKNDWLPSGLDNPRLSPPSPGGVRGKPGPPAQSSLGGRNPPLP-PSTGR-PAPAIPN-RPGG 826
            ||||.:.|    |.:.|.|||        |.|..|..| ..:.||| |::|| ||||||: .|..
Mouse   759 PPPVDDSW----LQHSRRSPP--------PSPTTQRRL-TISAPLPRPTSGRGPAPAIPSPGPHS 810

  Fly   827 GAPPLPGGRPGGSLP----------PPMLPSRVSGA 852
            ||||:| .|||...|          ||.:|||.:.|
Mouse   811 GAPPVP-FRPGPLPPFPNSSDSFGAPPQVPSRPTRA 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	195/238 (82%)
		CrfC	73..>498	CDD:223771	319/424 (75%)
		Dynamin_M	212..498	CDD:279383	202/285 (71%)
		PH_dynamin	512..644	CDD:269958	79/141 (56%)
		PH	552..638	CDD:278594	58/85 (68%)
		GED	664..755	CDD:128597	65/90 (72%)
		DUF4527	<758..819	CDD:291689	27/62 (44%)
		Drf_FH1	<761..>846	CDD:283903	40/97 (41%)
Dnm3	XP_006496664.1	DYNc	6..245	CDD:197491	195/238 (82%)
		Dynamin_M	216..502	CDD:366427	203/286 (71%)
		PH_dynamin	526..635	CDD:269958	77/129 (60%)
		GED	660..749	CDD:366984	63/88 (72%)
		MISS	<757..845	CDD:318115	42/101 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	441	1.000	Domainoid score	I540
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1128	1.000	Inparanoid score	I223
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52581
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	1	1.000	-	-		FOG0001563
OrthoInspector	1	1.000	-	-		otm44141
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2499
SonicParanoid	1	1.000	-	-		X876
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870