DRSC/TRiP Functional Genomics Resources

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Protein Alignment shi and DNM1L

DIOPT Version :9

Sequence 1:NP_001259588.1 Gene:shi / 45928 FlyBaseID:FBgn0003392 Length:896 Species:Drosophila melanogaster
Sequence 2:NP_001265393.1 Gene:DNM1L / 10059 HGNCID:2973 Length:749 Species:Homo sapiens


Alignment Length:807 Identity:303/807 - (37%)
Similarity:447/807 - (55%) Gaps:116/807 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 65
            |::||.::|||||.|.::|..: :.||||.|||.||:|||||||:.||:|.||||:|||||||||
Human     1 MEALIPVINKLQDVFNTVGADI-IQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLI 64

  Fly    66 LQLIN---------------------------GV--TEYGEFLHIKGKKFSSFDEIRKEIEDETD 101
            |||::                           ||  .|:|:|||.|.|.::.|||||:|||:||:
Human    65 LQLVHVSQEDKRKTTGEENDPATWKNSRHLSKGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETE 129

  Fly   102 RVTGSNKGISNIPINLRVYSPHVLNLTLIDLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLI 166
            |::|:|||:|..||:|:::||:|:||||:||||:|||.:||||.|||.||:::|.:||.....:|
Human   130 RISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSII 194

  Fly   167 LAVTPANTDLANSDALKLAKEVDPQGVRTIGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVN 231
            ||||.||||:|.|:|||:::||||.|.||:.|||||||||.||||.|:|..:::|::.|.|||||
Human   195 LAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVN 259

  Fly   232 RSQKDIEGRKDIHQALAAERKFFLSHPSYRHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQ 296
            |||.||..:|.:..::..|..|.  ...|..:|:|.||.||.|.||:.|.:||||.||.|:.:: 
Human   260 RSQLDINNKKSVTDSIRDEYAFL--QKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRI- 321

  Fly   297 KQMLTLEKEVEEFKHFQPGDASIKTKAMLQMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRI 361
             .:|..:.:.....:.:|.|.  |:..:||:|.:..:::..||||: :..:.|:||.|||:|..|
Human   322 -NVLAAQYQSLLNSYGEPVDD--KSATLLQLITKFATEYCNTIEGT-AKYIETSELCGGARICYI 382

  Fly   362 FHERL--RFEIVKMACDEKELRREISFAIRNIHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCV 424
            |||..  ..|.|........:  :|..||||..|.|..||.|:::||.:|||||..|:||.::||
Human   383 FHETFGRTLESVDPLGGLNTI--DILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCV 445

  Fly   425 DLVVQELSVVVRMC----TAKMSRYPRLREETERIITTHVRQREHSCKEQILLLIDFELAYMNTN 485
            :||.:|:..:::.|    |.::.|:|:|.:....::|..:|:|.....|.:..|:..||||:||.
Human   446 ELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTK 510

  Fly   486 HEDF---IGFANAQNKSENANKTGTRQLGNQVIRKGHMVIQNLGIMKDIKLGRSGPLNVRFFSPS 547
            |.||   .|..|...:.:..|:. .|:|.:.|.|.           |..|:..:       .:|:
Human   511 HPDFADACGLMNNNIEEQRRNRL-ARELPSAVSRD-----------KSSKVPSA-------LAPA 556

  Fly   548 TGGSRPYWFVLTSESISWYKDEDEKEKKFMLPLDGLKLRDIEQGFMSMSRRVTFALFSPDG---- 608
            :....|   ..::|:                  ||..::|        |||.|..:.|..|    
Human   557 SQEPSP---AASAEA------------------DGKLIQD--------SRRETKNVASGGGGVGD 592

  Fly   609 ----------RNVYKDYKQLELSCETVEDVESWKASFLRAGVYPEKQETQENGDESASEESSSDP 663
                      |.:.|..|..||..|.    :|.....:.|.  |:|.......|...........
Human   593 GVQEPTTGNWRGMLKTSKAEELLAEE----KSKPIPIMPAS--PQKGHAVNLLDVPVPVARKLSA 651

  Fly   664 QLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLIINNAKDFINGELLAHLYASGDQAQMMEES 728
            :.:|..|.|..|:.||..||.|..:|.||||:|..::|:.||.:..||:..||.|.....::.||
Human   652 REQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTES 716

  Fly   729 AESATRREEMLRMYRACKDALQIIGDV 755
            .:.|.||:|...|.:|.:.|.|||.::
Human   717 EDMAQRRKEAADMLKALQGASQIIAEI 743

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shiNP_001259588.1 DYNc 1..240 CDD:197491 147/267 (55%)
CrfC 73..>498 CDD:223771 191/433 (44%)
Dynamin_M 212..498 CDD:279383 105/294 (36%)
PH_dynamin 512..644 CDD:269958 25/145 (17%)
PH 552..638 CDD:278594 18/99 (18%)
GED 664..755 CDD:128597 35/90 (39%)
DUF4527 <758..819 CDD:291689
Drf_FH1 <761..>846 CDD:283903
DNM1LNP_001265393.1 DLP_1 23..315 CDD:206738 155/293 (53%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 32..39 4/6 (67%)
G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 58..60 1/1 (100%)
G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 159..162 2/2 (100%)
G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 228..231 2/2 (100%)
Dynamin_M 239..523 CDD:395818 105/292 (36%)
G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 258..261 2/2 (100%)
Middle domain. /evidence=ECO:0000269|PubMed:15208300 357..502 52/147 (35%)
Interaction with GSK3B. /evidence=ECO:0000269|PubMed:9731200 461..698 68/290 (23%)
B domain. /evidence=ECO:0000269|PubMed:15208300 515..582 19/114 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..603 17/113 (15%)
GED 655..743 CDD:396682 35/87 (40%)
Important for homodimerization. /evidence=ECO:0000269|PubMed:23584531 667..681 6/13 (46%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0699
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D141880at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100232
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.720

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