DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shi and dnm3

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_031757197.1	Gene:	dnm3 / 100489905	XenbaseID:	XB-GENE-1011531	Length:	837	Species:	Xenopus tropicalis

Alignment Length:	868	Identity:	512/868 - (58%)
Similarity:	638/868 - (73%)	Gaps:	72/868 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 65
            |:.||.:||:|||||:::|.:.|:|||||||||||||||||||||.||:               .
Frog     1 MEELIPLVNRLQDAFSAIGQNYQVDLPQIAVVGGQSAGKSSVLENLVGR---------------W 50

  Fly    66 LQLINGVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLI 130
            :.:::. |||.||||.||.|::.|.|:|:|||:||:|.||.|||||.|||:||:||||||||:||
Frog    51 IHVLSS-TEYAEFLHCKGTKYTDFSEVRQEIEEETERATGLNKGISAIPISLRIYSPHVLNLSLI 114

  Fly   131 DLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRT 195
            ||||:|||.:||||.|||.||:.||..||.:|.|||||||||||||||||||||||||||||:||
Frog   115 DLPGVTKVPVGDQPADIETQIRDMIMNFISRENCLILAVTPANTDLANSDALKLAKEVDPQGLRT 179

  Fly   196 IGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSY 260
            ||||||||||||||:|::|||||||||||||:||||||||||:|:|:|:.||.||:.|||:||:|
Frog   180 IGVITKLDLMDEGTNAQEILENKLLPLRRGYVGVVNRSQKDIDGKKNINAALQAEQMFFLTHPAY 244

  Fly   261 RHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKAML 325
            ||||||:||.:||::||||||||||:|||.||.|||.|:|:|:.|||.:|...|.|.|.||||:|
Frog   245 RHMADRMGTSHLQKMLNQQLTNHIRETLPDLRSKLQDQLLSLQHEVEVYKSINPDDPSRKTKALL 309

  Fly   326 QMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVKMACDEKELRREISFAIRN 390
            .|:|....|||:.|.|||.. |:|.|||||||||||||||..||:|||..||||||||||:||:|
Frog   310 HMVQHFAVDFEKRIAGSGDQ-VDTMELSGGAKINRIFHERFPFELVKMVFDEKELRREISYAIKN 373

  Fly   391 IHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVRMCTAKMSRYPRLREETERI 455
            |||:|.||||||:|||||||:||..||.|.:||||||:|||...::.||.|:|.||||..|||||
Frog   374 IHGVRTGLFTPDLAFEAIVKKQIVKLKGPALKCVDLVMQELINTIKKCTTKLSNYPRLCVETERI 438

  Fly   456 ITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIGFANAQNKSENANKTGTRQLGNQVIRKGHM 520
            :|.|:::.|...|:|:||:||.:|:|:||||||||||.|||.:.....|  ...:|.||||||.:
Frog   439 VTFHIKESEGKTKDQVLLMIDMQLSYINTNHEDFIGFVNAQQRCSLLQK--KTPIGIQVIRKGWL 501

  Fly   521 VIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLTSESISWYKDEDEKEKKFMLPLDGLKL 585
            .|.|:.|||                   ||::.|||:||:||:|||||::|||||:|||||.||:
Frog   502 TISNISIMK-------------------GGAKDYWFILTAESLSWYKDDEEKEKKYMLPLDNLKV 547

  Fly   586 RDIEQGFMSMSRRVTFALFSPDGRNVYKDYKQLELSCETVEDVESWKASFLRAGVYPEKQ--ETQ 648
            ||:|:|||| |:.: ||||:.:.|||||||:.|||:|::.|:|:|||||.|||||||:|.  :.:
Frog   548 RDVEKGFMS-SKHI-FALFNTEQRNVYKDYRCLELACDSQEEVDSWKASLLRAGVYPDKSMVDLE 610

  Fly   649 ENGDESASEESSSDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLIINNAKDFINGELLA 713
            ||   :.|:..|.|||||||||||||||:|||.|:.|..||::||.:|.|:||:.|:||:.||||
Frog   611 EN---TQSDNFSMDPQLERQVETIRNLVESYMTIINKGIRDLIPKTLMHLMINSVKEFIHSELLA 672

  Fly   714 HLYASGDQAQMMEESAESATRREEMLRMYRACKDALQIIGDVSMATVSSPLPPPVKNDWLPSGLD 778
            .||:..||:.:||||.|.:.:|||.|.||...|:||.||||:..:|..:|:||||.:.||
Frog   673 QLYSYEDQSTLMEESTEQSQKREEKLHMYYCLKEALHIIGDICTSTTYTPIPPPVDDSWL----- 732

  Fly   779 NPRLSP-PSPGGVRGKPGPPAQSSLGGRNPPLPPSTGRPAPAIPNRPGG--GAPPLPGGRPGGSL 840
            .|..|| .||............||:.|      ||.|...||..:.|..  ||||:| .|| |||
Frog   733 KPHRSPLESPTFQHSSSAITPMSSITG------PSAGHSLPAAISLPNAHVGAPPVP-SRP-GSL 789

  Fly   841 P-----------PPMLPSRVSGA 852
            |           ||.:|||.|.|
Frog   790 PTLPNINDPALIPPQIPSRPSRA 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	166/238 (70%)
		CrfC	73..>498	CDD:223771	299/424 (71%)
		Dynamin_M	212..498	CDD:279383	191/285 (67%)
		PH_dynamin	512..644	CDD:269958	74/131 (56%)
		PH	552..638	CDD:278594	55/85 (65%)
		GED	664..755	CDD:128597	54/90 (60%)
		DUF4527	<758..819	CDD:291689	19/61 (31%)
		Drf_FH1	<761..>846	CDD:283903	34/98 (35%)
dnm3	XP_031757197.1	DYNc	1..224	CDD:197491	166/238 (70%)
		Dynamin_M	195..481	CDD:395818	192/286 (67%)
		PH_dynamin	494..604	CDD:269958	74/130 (57%)
		GED	626..714	CDD:396682	51/87 (59%)
		PHA03247	<717..834	CDD:223021	40/109 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	437	1.000	Domainoid score	I552
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1128	1.000	Inparanoid score	I226
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	1	1.000	-	-		FOG0001563
OrthoInspector	1	1.000	-	-		otm49319
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X876
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060