DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shi and dnm1b

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_005165639.1	Gene:	dnm1b / 100333543	ZFINID:	ZDB-GENE-100920-3	Length:	859	Species:	Danio rerio

Alignment Length:	870	Identity:	584/870 - (67%)
Similarity:	691/870 - (79%)	Gaps:	53/870 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 65
            |:.||.:||::||||:::|.:..|||||||||||||||||||||||||||||||||||||||||:
Zfish     6 MEDLIPLVNRMQDAFSAIGQNANLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLV 70

  Fly    66 LQLINGVTEYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVLNLTLI 130
            |||||..|||.||||.|||||:.|||:|:|||.||||:||.|||||.:|||||||||:||||||:
Zfish    71 LQLINCPTEYAEFLHCKGKKFTDFDEVRQEIEAETDRITGQNKGISPVPINLRVYSPNVLNLTLV 135

  Fly   131 DLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRT 195
            ||||:|||.:||||.|||.||:.|:.||:.||.||:|||:|||:|||||||||:||||||||:||
Zfish   136 DLPGMTKVPVGDQPADIEAQIRDMLMQFVTKENCLLLAVSPANSDLANSDALKIAKEVDPQGMRT 200

  Fly   196 IGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIHQALAAERKFFLSHPSY 260
            |||||||||||||||||:||||||||||||||||||||||||:|:|||..|::|||||||:||||
Zfish   201 IGVITKLDLMDEGTDAREILENKLLPLRRGYIGVVNRSQKDIDGKKDITAAMSAERKFFLTHPSY 265

  Fly   261 RHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEFKHFQPGDASIKTKAML 325
            ||:|||:||||||:.|||||||||||||||||:|||.|:|::||||||:|||:|.|.|.||||:|
Zfish   266 RHLADRMGTPYLQKALNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVEEYKHFRPDDPSRKTKALL 330

  Fly   326 QMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVKMACDEKELRREISFAIRN 390
            ||:||...|||:.|||||.. |:|.||||||:||||||||..||:|||..||||||:|||:||:|
Zfish   331 QMVQQFAVDFEKCIEGSGDQ-VDTVELSGGARINRIFHERFPFELVKMEFDEKELRKEISYAIKN 394

  Fly   391 IHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVRMCTAKMSRYPRLREETERI 455
            |||||.||||||||||.|||||||.:|||..||||||:.||...||.||.|:::||.||||.|||
Zfish   395 IHGIRTGLFTPDMAFETIVKRQIAKIKEPCQKCVDLVITELVNTVRQCTKKLAQYPMLREEMERI 459

  Fly   456 ITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIGFANAQNKSENANKTGTRQLGNQ----VIR 516
            :|.|:|.||...|.|::||||.|||||||||||||||||||.:|...||  .:..|||    |||
Zfish   460 VTQHIRDRESRTKNQVMLLIDIELAYMNTNHEDFIGFANAQQRSSQMNK--KKAAGNQDEIMVIR 522

  Fly   517 KGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLTSESISWYKDEDEKEKKFMLPLD 581
            ||.:.|.|:||||                   ||::.||||:|:|::|||||::|||||:|||||
Zfish   523 KGWLTINNIGIMK-------------------GGAKEYWFVMTAENLSWYKDDEEKEKKYMLPLD 568

  Fly   582 GLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKDYKQLELSCETVEDVESWKASFLRAGVYPE--- 643
            .|||||||:.||| |:.| ||||:.:.|||||||:||||:.:|.|:|:||||||||||||||
Zfish   569 NLKLRDIEKSFMS-SKHV-FALFNTEQRNVYKDYRQLELASDTQEEVDSWKASFLRAGVYPERIT 631

  Fly   644 -KQETQENGDESASE--ESSSDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLIINNAKD 705
             |::..:..|||:|:  ..|.|||||||||||||||||||.||.||.||::||.||.|:|||.||
Zfish   632 DKEKQSDTSDESSSDGFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKD 696

  Fly   706 FINGELLAHLYASGDQAQMMEESAESATRREEMLRMYRACKDALQIIGDVSMATVSSPLPPPVKN 770
            ||:.||||:||:.|||..:||||||.|..||||||||.|.|:||.||||:|.:|||:.:||||.:
Zfish   697 FIHAELLANLYSCGDQNTLMEESAEQAQHREEMLRMYHALKEALNIIGDISTSTVSTAMPPPVDD 761

  Fly   771 DWL-----PSGLDNPRLSPPSPGGVRGKPGPPAQSSLGGRNPPLPPSTGRPAPAIPNRPGGGAPP 830
            .||     |||..:| :|.|:|.. |..||||..   |||..|.||:.|  ||.:|:||  ||.|
Zfish   762 SWLQVQGGPSGRRSP-MSSPTPQR-RAPPGPPRP---GGRTAPGPPTIG--APPVPSRP--GASP 817

  Fly   831 LPGGRPGGSLPPPMLPSRVSGAVGG 855
            .|.|     .|||.:|||.:.|..|
Zfish   818 DPFG-----APPPQVPSRPNRAPPG 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	190/238 (80%)
		CrfC	73..>498	CDD:223771	322/424 (76%)
		Dynamin_M	212..498	CDD:279383	213/285 (75%)
		PH_dynamin	512..644	CDD:269958	80/139 (58%)
		PH	552..638	CDD:278594	58/85 (68%)
		GED	664..755	CDD:128597	66/90 (73%)
		DUF4527	<758..819	CDD:291689	29/65 (45%)
		Drf_FH1	<761..>846	CDD:283903	39/89 (44%)
dnm1b	XP_005165639.1	DYNc	6..245	CDD:197491	190/238 (80%)
		CrfC	78..745	CDD:223771	479/690 (69%)
		Dynamin_M	217..502	CDD:279383	213/285 (75%)
		PH_dynamin	519..629	CDD:269958	77/130 (59%)
		GED	658..746	CDD:280391	63/87 (72%)
		WWbp	<714..837	CDD:304964	69/136 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	438	1.000	Domainoid score	I538
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123905
Inparanoid	1	1.050	1121	1.000	Inparanoid score	I214
OMA	1	1.010	-	-		QHG52581
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	1	1.000	-	-		FOG0001563
OrthoInspector	1	1.000	-	-		otm24243
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2499
SonicParanoid	1	1.000	-	-		X876
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.870