DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shi and opa1

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_001120510.2	Gene:	opa1 / 100145638	XenbaseID:	XB-GENE-989058	Length:	1010	Species:	Xenopus tropicalis

Alignment Length:	676	Identity:	155/676 - (22%)
Similarity:	260/676 - (38%)	Gaps:	171/676 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLITIVNKLQDAFT--SLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSG-IVTRRPL 64
            |||.:.:::.|..:  ....:.|..||::.|||.|||||:||||........||||| ::||.|:
Frog   313 SLIDMYSEVLDILSDYDANYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPV 377

  Fly    65 ILQLINGVTEYGEFLHIKGKKFSS--FD--------EIRKEIEDETDRVTGSNKGISNIPINLRV 119
            .:.|..|..      |:...|.||  ||        .:|.|||....:...:.:.:|...|:|.|
Frog   378 KVTLSEGPH------HVAMFKDSSREFDLSKETDLAALRNEIEVRMRKSVKNGQTVSPETISLSV 436

  Fly   120 YSPHVLNLTLIDLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKL 184
            ..|.:..:.|:||||:..........|.:..|..:...::.....:||.:...:.|...|....|
Frog   437 KGPGIQRMVLVDLPGVINTVTSGMAPDTKDTIFNISKAYMLNPNAIILCIQDGSVDAERSIVTDL 501

  Fly   185 AKEVDPQGVRTIGVITKLDLMDEGTDA----RDILENKLLPLRR-GYIGVV---NRSQKDIEGRK 241
            ..::||||.|||.|:||:||.::...:    :.|:|.||.|::. ||..||   ..|.:.|:..|
Frog   502 VSQMDPQGRRTIFVLTKVDLAEKNVASPNRIQQIIEGKLFPMKALGYFAVVTGKGNSNESIDSIK 566

  Fly   242 DIHQALAAERKFFLSHPSYRHMADRLGTPYLQRVL---NQQLTNHIRDTLPGLRDKLQKQMLTLE 303
            |.      |.:||            .|:..|::.:   :|..|.::...:.....|:.::  ::|
Frog   567 DY------EEEFF------------QGSSLLKKGMLKAHQVTTKNLSLAVSDCFWKMVRE--SIE 611

  Fly   304 KEVEEFKHFQPGDASIKTKAMLQMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRF 368
            ::.:.||         .|:..|:  .:.::::.|..|      ::.|||...|| |.|..|.:..
Frog   612 QQADAFK---------ATRFNLE--TEWKNNYPRLRE------LDRNELFEKAK-NEILDEVISL 658

  Fly   369 EIVKMACDEKELRREI-----SFAIRNIH-----GIRVGLF--TPDMAFEAIVKRQIALLKEPVI 421
            ..|.....|:.|:|.:     :..|.||:     .:..|.|  |.|:..:....:|:.      .
Frog   659 TQVTPKHWEEILQRTMWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLP------N 717

  Fly   422 KCVDLVVQELSVVVRMCTAKMSRYPRLREETERIITTHVRQREHSCKEQILLLIDFELAYMNTNH 486
            |.|::.                 :..|::|..|.:|      |...||                |
Frog   718 KAVEVA-----------------WETLQQEFSRFMT------EQKGKE----------------H 743

  Fly   487 EDFIGFANAQNKSENANKTGTRQLGNQVIRKGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGS 551
            :|.........|.|:..    |...|:.......|||:
Frog   744 DDIFDKLKESVKEESIK----RHKWNEQAEDSLRVIQH--------------------------- 777

  Fly   552 RPYWFVLTSESISWYKDEDEKEKKFMLPLDGL--KLRDIEQGFMSM------SRRVTFALFSPDG 608
                ..|...|||   |:.:.:.......|.|  :|:|.|.....|      .|.:::...|||.
Frog   778 ----NALEDRSIS---DKQQWDAAIHFMEDTLQSRLKDTESVIRDMVGPDWKERWISWTSRSPDQ 835

  Fly   609 RNVYKDYKQLELSCETVEDVESWKAS 634
            ....:..|:||...:..||..::.|:
Frog   836 HTRNETKKELEKMLKVNEDHPAYLAN 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	79/257 (31%)
		CrfC	73..>498	CDD:223771	98/457 (21%)
		Dynamin_M	212..498	CDD:279383	59/304 (19%)
		PH_dynamin	512..644	CDD:269958	25/131 (19%)
		PH	552..638	CDD:278594	21/91 (23%)
		GED	664..755	CDD:128597
		DUF4527	<758..819	CDD:291689
		Drf_FH1	<761..>846	CDD:283903
opa1	NP_001120510.2	DLP_1	337..611	CDD:206738	84/299 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910