DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shi and drp2

DIOPT Version :9

Sequence 1:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_001096188.1	Gene:	drp2 / 100124737	XenbaseID:	XB-GENE-994502	Length:	930	Species:	Xenopus tropicalis

Alignment Length:	804	Identity:	149/804 - (18%)
Similarity:	247/804 - (30%)	Gaps:	302/804 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 DQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKE------VD--PQGVRTIGV 198
            ||...:|:.::|:      :|  |.:::..|...:...::::.:.|      :|  |..::|
Frog   192 DQHRHLERTLEQI------QE--LGISMKEAGDSIGQGESVQASWEPIGDLFIDSLPDHIQT--- 245

  Fly   199 ITKLDLMDEGTDARDI--LENKL---LPLRRGYIGVVN-RSQKDIEGR---------------KD 242
             ||| ..:|.:..:|:  |.|.|   |.|...::.:.| |..::|..|               :|
Frog   246 -TKL-FKEELSPIKDMVKLANDLAHQLALCDVHLSMENARELENINSRWKQLQTSVGERLRQLQD 308

  Fly   243 IHQALAAERKFFLS------------------------------HPSYRHMADRLG-------TP 270
            .|:....|.:.|||                              ||....:...||       :.
Frog   309 AHRDFGPESQHFLSSSVQVPWERAISPNKVPYYINHQAQTTCWDHPKMTELYQALGDLNNIKFSA 373

  Fly   271 Y--------LQRVLNQQLTNHIRDTLPGLR-----DKLQKQMLTLEKEVEEFKHFQPGDASIKTK 322
            |        :|:.|...|.     |||.|.     |.||.....|:
Frog   374 YRTAMKLRRVQKALRLDLV-----TLPLLTQIFTCDTLQSPERNLD------------------- 414

  Fly   323 AMLQMIQQLQSDFERTIEGSGSALVNTN-----------ELSGGAKINRIFHERLRFEIVKM--- 373
             :|.:|:.|.|.:||..|..| .|||..           .:..||:..||.....:..||.:
Frog   415 -VLDVIRCLSSLYERLEEERG-LLVNVPLCVDLTLNWLLNVFDGARNGRIRVLSFKAGIVSLCDC 477

  Fly   374 ------------------ACDEKELRREISFAIR--------------NIHG-----IRVGLFTP 401
                              .||:::|...:..||:              |:..     .|.|..|.
Frog   478 DVKGKLQYLFSQVASPGNTCDQRQLGLLLHEAIQIPRQLGEVAAFGGSNVEPSVRSCFRFGNGTA 542

  Fly   402 DMAFEAIVK----RQIALLKEPVIKCVDLVV----QELSVVVRMCTAKMSRYPRLREETERIITT 458
            .:.....::    ...:::..||:..|.|..    |....|.:.|..|..||..|::....|.
Frog   543 HLELAQFLEWGCLEPQSMVWLPVLHRVTLAETVKHQAKCSVCKQCPMKGFRYRSLKQFGVDIC-- 605

  Fly   459 HVRQREHSCKEQILLLIDFELAYMNTNHEDFIGFANAQNKSEN--------ANKTGTRQLGNQVI 515
                  .||      .:..:...:|..|...:.:.......|.        .||..|||..::..
Frog   606 ------QSC------FLTGQAGKVNKLHYPIMEYYTPTTSGEKMRDFATTLKNKFRTRQYFSRHP 658

  Fly   516 RKGHMVIQNLGIMKDIKLGRSGPL-----------------------NVRFF----SPSTGGSRP 553
            ::|::.:|::...:......|.|:                       |..||    ||.......
Frog   659 QRGYLPVQSVLEAEVADTPASSPMLPHADTHSRIEHFASRLAEMESQNCSFFTDSLSPDDSLDED 723

  Fly   554 YWFVLTSESISWYKDED---------------------------EKEKKFML-PLDGLKLRDIEQ 590
            .:.:..|..|:   |.|                           |.|.:.:. .|..||.:..|.
Frog   724 QYLLRHSSPIT---DRDPSNTPQIPGNLNPEEEQGELEKILAHLEHENRILQGELKRLKWQHAEA 785

  Fly   591 GFMSMSRRVTFALFSPD-GRN---------------VYKDYK-QLELSCETVEDVESWKASFLRA 638
            |.:|....|     ||| |.|               :.:.:| :||...:.:||......|.||
Frog   786 GEVSALGEV-----SPDVGGNGVGEAQSEELLSEARILRHHKNRLETRMQILEDHNKQLESQLR- 844

  Fly   639 GVYPEKQE--TQENGDESASEESSSDPQLERQVETIRNL----------VDSYMKIVTKTTRDMV 691
                ..:|  .|.|.||.....|||.|..:.:.....|.          |:|..:.|.....|::
Frog   845 ----RLRELLLQPNTDEGKPSSSSSSPDSQSKCPAEGNAGTPDTEAADDVESRTREVGLCLEDIM 905

  Fly   692 PKAIMMLIINNAKDFINGELLAHL 715
            .|      :.||........:||:
Frog   906 EK------LRNAFPNTTDSDIAHV 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shi	NP_001259588.1	DYNc	1..240	CDD:197491	24/111 (22%)
		CrfC	73..>498	CDD:223771	89/493 (18%)
		Dynamin_M	212..498	CDD:279383	74/415 (18%)
		PH_dynamin	512..644	CDD:269958	35/203 (17%)
		PH	552..638	CDD:278594	25/130 (19%)
		GED	664..755	CDD:128597	10/62 (16%)
		DUF4527	<758..819	CDD:291689
		Drf_FH1	<761..>846	CDD:283903
drp2	NP_001096188.1	SPEC	82..310	CDD:238103	26/130 (20%)
		WW	328..356	CDD:238122	2/27 (7%)
		EFh_DRP-2	393..554	CDD:320006	34/181 (19%)
		EF-hand-like motif	393..431	CDD:320006	14/57 (25%)
		EF-hand-like motif	439..473	CDD:320006	5/33 (15%)
		EF-hand-like motif	479..515	CDD:320006	5/35 (14%)
		EF-hand-like motif	528..554	CDD:320006	3/25 (12%)
		ZZ	579..627	CDD:294208	11/61 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900