Protein Alignment fzr and AMA1

DIOPT Version :10

• Sequence 1: NP_524852.2
• Gene: fzr / 45922
• FlyBaseID: FBgn0262699
• Length: 478
• Species: Drosophila melanogaster
• Sequence 2: NP_011741.5
• Gene: AMA1 / 853140
• SGDID: S000003457
• Length: 593
• Species: Saccharomyces cerevisiae
• Alignment Length: 540
• Identity: 156/540 - (28%)
• Similarity: 252/540 - (46%)
• Gaps: 113/540 - (20%)

  Fly     3 SPEY--EKRILKHYSPVARNLFNNFESSTTPTSLDRFIPCRAYNNWQTNFASINKSNDNSPQTSK 65
            |||:  |.|...||..::..  |.|..|:..:|.:..:         |...|...|.::..:.:|
Yeast    69 SPEFFNELRNTGHYESISTT--NEFSMSSISSSSESQV---------TRSGSARASRNDYSKLTK 122

  Fly    66 KQRDCGETARDSLAYSCLLKNELLGSAIDD-----VKTAGE--ERN---ENAYTP---AAKRSLF 117
            :|:|    .|.::|:|       ||..:.|     ..|:.|  |:|   :|.:.|   |..||.|
Yeast   123 EQKD----HRKNIAHS-------LGFQLPDRVFTFETTSAEILEKNKAIKNCFGPGSCAEIRSTF 176

  Fly   118 KYQ--SPTKQDYNGECPY--SLSPVSAKSQKLLRSPRKATRKISRIPFKVLDAPELQDDFYLNLV 178
            .:.  ||....|     |  :.:..||..|:.::.|.|..:  |.||::|||||.|::|||.||:
Yeast   177 DFSTLSPDVARY-----YIANSNARSASPQRQIQRPAKRVK--SHIPYRVLDAPCLRNDFYSNLI 234

  Fly   179 DWS--SQNVLAVGLGSCVYLWSACTSQVTRLCD--LSPDANTVTSVSWNERGNTVAVGTHHGYVT 239
            .||  :.||| ||||..||:||.....|:.|..  ||...:.||.||:........|||..|.:.
Yeast   235 SWSRTTNNVL-VGLGCSVYIWSEKEGAVSILDHQYLSEKRDLVTCVSFCPYNTYFIVGTKFGRIL 298

  Fly   240 VWDVAANKQINKLNGHSAR-----------------VGALAW--------------NSDI-LSSG 272
            ::|       .|...||:.                 :..|.|              |.:: |...
Yeast   299 LYD-------QKEFFHSSNTNEKEPVFVFQTESFKGICCLEWFKPGEICKFYVGEENGNVSLFEI 356

  Fly   273 SRDRWIIQRDTRTPQLQSERRLA--------GHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHS 329
            ....:.|:..::..:|:.|..:.        ...|:|||:..:.....||.|||||...:|:...
Yeast   357 KSLHFPIKNWSKRQKLEDENLIGLKLHSTYQAQAQQVCGISLNEHANLLAVGGNDNSCSLWDISD 421

  Fly   330 VN-PVQSYT-EHMAAVKAIAWSPHHHGLLASGGGTADRCIRFWNTLTGQPMQCVDTGSQVCNLAW 392
            :: |::.:. .|.|||||||:.|....|||:|||:.||||:||:|.||..:..:.|..||.:|.|
Yeast   422 LDKPIKKFVLPHKAAVKAIAFCPWSKSLLATGGGSKDRCIKFWHTSTGTLLDEICTSGQVTSLIW 486

  Fly   393 SKHSSELVSTHGY--SQNQILV--WKYPSLTQVAKL-TGHSYRVLYLALSPDGEAIVTGAGDETL 452
            |....::|:|.|:  ::|.:|:  :.||.|:::.:: :.:..|||...:||...||.....|||:
Yeast   487 SLRHKQIVATFGFGDTKNPVLITLYSYPKLSKLLEVRSPNPLRVLSAVISPSSMAICVATNDETI 551

  Fly   453 RFWNVFSKARSQKENKSVLN 472
            ||:.:::      :.:.::|
Yeast   552 RFYELWN------DKEEIIN 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fzr	NP_524852.2	WD40	<194..457	CDD:441893	90/311 (29%)
		WD40 repeat	217..254	CDD:293791	10/36 (28%)
		WD40 repeat	260..296	CDD:293791	7/58 (12%)
		WD40 repeat	301..337	CDD:293791	12/36 (33%)
		WD40 repeat	344..382	CDD:293791	20/37 (54%)
		WD40 repeat	387..425	CDD:293791	12/42 (29%)
		WD40 repeat	431..457	CDD:293791	11/25 (44%)
AMA1	NP_011741.5	WD40 repeat	234..271	CDD:293791	16/37 (43%)
		WD40	266..561	CDD:475233	84/307 (27%)
		WD40 repeat	276..321	CDD:293791	12/51 (24%)
		WD40 repeat	328..374	CDD:293791	6/45 (13%)
		WD40 repeat	394..432	CDD:293791	11/37 (30%)
		WD40 repeat	437..474	CDD:293791	21/36 (58%)
		WD40 repeat	482..523	CDD:293791	11/40 (28%)