DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzr and CDC20

DIOPT Version :9

Sequence 1:	NP_524852.2	Gene:	fzr / 45922	FlyBaseID:	FBgn0262699	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	NP_011399.1	Gene:	CDC20 / 852762	SGDID:	S000003084	Length:	610	Species:	Saccharomyces cerevisiae

Alignment Length:	327	Identity:	128/327 - (39%)
Similarity:	190/327 - (58%)	Gaps:	17/327 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 RKISRIPFKVLDAPELQDDFYLNLVDWSSQNVLAVGLGSCVYLWSACTSQVTRLCDLSPDANTVT 218
            |||:..|.::||||..||||||||:.||.:||||:.|.:.:|||:|.|..|:.|.|.  :..|:.
Yeast   243 RKINTNPERILDAPGFQDDFYLNLLSWSKKNVLAIALDTALYLWNATTGDVSLLTDF--ENTTIC 305

  Fly   219 SVSWNERGNTVAVGTHHGYVTVWDVAANKQINKL-NGHSARVGALAWNSDILSSGSRDRWIIQRD 282
            ||:|::....:::|...|...:|||.....|..: :|...|:|:|:|...::::|||...|...|
Yeast   306 SVTWSDDDCHISIGKEDGNTEIWDVETMSLIRTMRSGLGVRIGSLSWLDTLIATGSRSGEIQIND 370

  Fly   283 TRTPQLQSERRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSVNPVQSYTEHMAAVKAIA 347
            .|..| ......|.|..|||||.:..|...||||||||.:.:|:..:..|..|...|.|||||::
Yeast   371 VRIKQ-HIVSTWAEHTGEVCGLSYKSDGLQLASGGNDNTVMIWDTRTSLPQFSKKTHTAAVKALS 434

  Fly   348 WSPHHHGLLASGGGTADRCIRFWNTLTGQPMQCVDTGSQVCNLAWSK-HSS--------ELVSTH 403
            |.|:...:||||||..|:.|.|||::||..:..::|||||.:|.|.: |:|        |:|:|.
Yeast   435 WCPYSPNILASGGGQTDKHIHFWNSITGARVGSINTGSQVSSLHWGQSHTSTNGGMMNKEIVATG 499

  Fly   404 GYSQNQILVWKYPSLTQVAKLT-GHSYRVLYLALSPDGEAIVTGAGDETLRFWNVFS---KARSQ 464
            |..:|.|.|:.|.:..:||::. .|..|:....|||||..:.|..|||.|:|:.:|.   ..||:
Yeast   500 GNPENAISVYNYETKFKVAEVVHAHEARICCSQLSPDGTTLATVGGDENLKFYKIFDPRCTGRSR 564

  Fly   465 KE 466
            ::
Yeast   565 ED 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr	NP_524852.2	WD40	<174..469	CDD:225201	116/307 (38%)
		WD40	178..456	CDD:238121	109/288 (38%)
		WD40 repeat	217..254	CDD:293791	9/37 (24%)
		WD40 repeat	260..296	CDD:293791	10/35 (29%)
		WD40 repeat	301..337	CDD:293791	16/35 (46%)
		WD40 repeat	344..382	CDD:293791	17/37 (46%)
		WD40 repeat	387..425	CDD:293791	15/46 (33%)
		WD40 repeat	431..457	CDD:293791	11/25 (44%)
CDC20	NP_011399.1	WD40	<240..560	CDD:225201	126/319 (39%)
		WD40 repeat	265..301	CDD:293791	17/37 (46%)
		WD40 repeat	304..340	CDD:293791	9/35 (26%)
		WD40 repeat	348..381	CDD:293791	10/33 (30%)
		WD40 repeat	388..422	CDD:293791	15/33 (45%)
		WD40 repeat	430..476	CDD:293791	23/45 (51%)
		WD40 repeat	528..562	CDD:293791	12/33 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810