DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr and CDC20.5

DIOPT Version :9

Sequence 1:	NP_524852.2	Gene:	fzr / 45922	FlyBaseID:	FBgn0262699	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	NP_198109.2	Gene:	CDC20.5 / 832817	AraportID:	AT5G27570	Length:	450	Species:	Arabidopsis thaliana

Alignment Length:	457	Identity:	183/457 - (40%)
Similarity:	259/457 - (56%)	Gaps:	51/457 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SLDRFIPCRAYNNWQTNFASINKSNDNSPQTSKKQRDCGE-TARDSLAYSCLLKNELLGSAIDDV 96
            :.|||||.|:..::  :||       |...|..::|:..| |:....||...|
plant    29 NFDRFIPNRSAMDF--DFA-------NYALTQGRKRNVDEVTSASRKAYMTQL------------ 72

  Fly    97 KTAGEERNENAYTPAAKRSLFKYQSPTKQDYNGECPYSLSPVSAKSQKLLRSPRKATRKISRIPF 161
               .|..|:|.....|    |:.:.......|...|....|:|.|.::.:  |:.:.|
plant    73 ---AEAMNQNRTRILA----FRNKPKALLSSNHSDPPHQQPISVKPRRYI--PQNSER------- 121

  Fly   162 KVLDAPELQDDFYLNLVDWSSQNVLAVGLGSCVYLWSACTSQVTRLCDLSPDANTVTSVSWNERG 226
             |||||.:.|||||||:||.|.||||:.||..||||.|.:....:|..:..:...|||::|.:.|
plant   122 -VLDAPGIADDFYLNLLDWGSSNVLAIALGDTVYLWDASSGSTYKLVTIDEEEGPVTSINWTQDG 185

  Fly   227 NTVAVGTHHGYVTVWDVAANKQINKL-NGHSARVGALAWNSDILSSGSRDRWIIQRDTRTPQLQS 290
            ..:|:|..:..|.:||..:|:|:..| .||.:|||:||||:.||::|..|..|:..|.|......
plant   186 LDLAIGLDNSEVQLWDCVSNRQVRTLRGGHESRVGSLAWNNHILTTGGMDGKIVNNDVRIRSSIV 250

  Fly   291 ERRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSV---NPVQS----YTEHMAAVKAIAW 348
            |..| ||.:||||||||...:.||||||||.:::|:..||   ||.:.    :.||.|||:|:||
plant   251 ETYL-GHTEEVCGLKWSESGKKLASGGNDNVVHIWDHRSVASSNPTRQWLHRFEEHTAAVRALAW 314

  Fly   349 SPHHHGLLASGGGTADRCIRFWNTLTGQPMQCVDTGSQVCNLAWSKHSSELVSTHGYSQNQILVW 413
            .|....|||:|||..|..|:||||.||..:..|:||||||:|.|||...||:|:||::|||:.:|
plant   315 CPFQASLLATGGGVGDGKIKFWNTHTGACLNSVETGSQVCSLLWSKSERELLSSHGFTQNQLTLW 379

  Fly   414 KYPSLTQVAKLTGHSYRVLYLALSPDGEAIVTGAGDETLRFWNVFS---KARSQKENKSVLNLFA 475
            ||||:.::|:|.||:.|||::|.||||..:.:.|||||||.||||.   |...:..:|...:.||
plant   380 KYPSMVKMAELNGHTSRVLFMAQSPDGCTVASAAGDETLRLWNVFGEPPKTTKKAASKKYTDPFA 444

  Fly   476 NI 477
            ::
plant   445 HV 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr	NP_524852.2	WD40	<174..469	CDD:225201	144/305 (47%)
		WD40	178..456	CDD:238121	135/285 (47%)
		WD40 repeat	217..254	CDD:293791	13/37 (35%)
		WD40 repeat	260..296	CDD:293791	14/35 (40%)
		WD40 repeat	301..337	CDD:293791	20/42 (48%)
		WD40 repeat	344..382	CDD:293791	18/37 (49%)
		WD40 repeat	387..425	CDD:293791	20/37 (54%)
		WD40 repeat	431..457	CDD:293791	15/25 (60%)
CDC20.5	NP_198109.2	WD40	<140..428	CDD:225201	137/288 (48%)
		WD40 repeat	177..214	CDD:293791	12/36 (33%)
		WD40 repeat	219..251	CDD:293791	13/31 (42%)
		WD40 repeat	261..303	CDD:293791	19/41 (46%)
		WD40 repeat	309..345	CDD:293791	19/35 (54%)
		WD40 repeat	353..391	CDD:293791	20/37 (54%)
		WD40 repeat	397..421	CDD:293791	14/23 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54440
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830