DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzr and CDC20.3

DIOPT Version :9

Sequence 1:	NP_524852.2	Gene:	fzr / 45922	FlyBaseID:	FBgn0262699	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	NP_198060.2	Gene:	CDC20.3 / 832766	AraportID:	AT5G27080	Length:	442	Species:	Arabidopsis thaliana

Alignment Length:	462	Identity:	179/462 - (38%)
Similarity:	265/462 - (57%)	Gaps:	61/462 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SLDRFIPCRAYNNWQTNFASINKSNDNSPQTSKKQRDCGE-TARDSLAYSCLLKNELLGSAIDDV 96
            :||||||.|:..::  :||       |...|..::|:..| |:....||...|...:
plant    21 NLDRFIPNRSAMDF--DFA-------NYALTQGRKRNVDEITSASRKAYMTQLAVVM-------- 68

  Fly    97 KTAGEERNENAYTPAAKRSLFKYQSPTK---QDYNGECPYSLSPVSAKSQKLLRSPRKATRKISR 158
                   |:|      :..:..:::..|   ...:.:.|:. :|.|.|.::.:  |:.:.|
plant    69 -------NQN------RTRILAFRNKPKALLSSNHSDSPHQ-NPKSVKPRRYI--PQNSER---- 113

  Fly   159 IPFKVLDAPELQDDFYLNLVDWSSQNVLAVGLGSCVYLWSACTSQVTRLCDLSPDANTVTSVSWN 223
                |||||.|.|||||||:||.|.||||:.||..||||.|.:...:.|..:..|...|||::|.
plant   114 ----VLDAPGLMDDFYLNLLDWGSANVLAIALGDTVYLWDASSGSTSELVTIDEDKGPVTSINWT 174

  Fly   224 ERGNTVAVGTHHGYVTVWDVAANKQINKL-NGHSARVGALAWNSDILSSGSRDRWIIQRDTRTPQ 287
            :.|..:|||..:..|.:||..:|:|:..| .||.:|||:||||:.||::|..|..|:..|.|
plant   175 QDGLDLAVGLDNSEVQLWDFVSNRQVRTLIGGHESRVGSLAWNNHILTTGGMDGKIVNNDVR--- 236

  Fly   288 LQSE--RRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSV---NPVQS----YTEHMAAV 343
            ::|.  ....||.:||||||||...:.||||||.|.:::|:..||   .|.:.    :.||.|||
plant   237 IRSSIVGTYLGHTEEVCGLKWSESGKKLASGGNYNVVHIWDHRSVASSKPTRQWLHRFEEHTAAV 301

  Fly   344 KAIAWSPHHHGLLASGGGTADRCIRFWNTLTGQPMQCVDTGSQVCNLAWSKHSSELVSTHGYSQN 408
            :|:||.|....|||:|||..|..|:||||.||..:..|:||||||:|.||:...||:|:||::||
plant   302 RALAWCPFQATLLATGGGVGDGKIKFWNTHTGACLNSVETGSQVCSLLWSQRERELLSSHGFTQN 366

  Fly   409 QILVWKYPSLTQVAKLTGHSYRVLYLALSPDGEAIVTGAGDETLRFWNVFS---KARSQKENKSV 470
            |:.:|||||::::|:|.||:.|||::|.||:|..:.:.||||.||.||||.   |...:..:|:.
plant   367 QLTLWKYPSMSKMAELNGHTSRVLFMAQSPNGCTVASAAGDENLRLWNVFGEPPKTTKKAASKNY 431

  Fly   471 LNLFANI 477
            |.||:::
plant   432 LELFSHV 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr	NP_524852.2	WD40	<174..469	CDD:225201	140/307 (46%)
		WD40	178..456	CDD:238121	131/287 (46%)
		WD40 repeat	217..254	CDD:293791	14/37 (38%)
		WD40 repeat	260..296	CDD:293791	13/37 (35%)
		WD40 repeat	301..337	CDD:293791	18/42 (43%)
		WD40 repeat	344..382	CDD:293791	18/37 (49%)
		WD40 repeat	387..425	CDD:293791	19/37 (51%)
		WD40 repeat	431..457	CDD:293791	13/25 (52%)
CDC20.3	NP_198060.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54440
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830