DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr and FZR3

DIOPT Version :9

Sequence 1:	NP_524852.2	Gene:	fzr / 45922	FlyBaseID:	FBgn0262699	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	NP_001190305.1	Gene:	FZR3 / 831230	AraportID:	AT5G13840	Length:	481	Species:	Arabidopsis thaliana

Alignment Length:	469	Identity:	245/469 - (52%)
Similarity:	302/469 - (64%)	Gaps:	43/469 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LKHYSPVARNLFNNFESSTTPTSLDRFIPCRAYNNWQTNFASINKSNDNSPQTSKKQRDCGETAR 75
            |:.:|...|.: ::..|.:..|..|||||||:.:....     ....|..|.|..|:       .
plant    24 LETFSSSFRGI-SSLSSPSKSTCSDRFIPCRSSSRLHA-----FDLQDKEPTTPVKE-------G 75

  Fly    76 DSLAYSCLLKNELLGS--AIDDVKTAGEERNENA-YTPAAKRSLFKYQSPTKQDYNGECPYSLSP 137
            .:.|||.|||:||.||  |...:..||.:.:.:: .:|......||......           ||
plant    76 GNEAYSRLLKSELFGSDFASPLLSPAGGQGSASSPMSPCTNMLRFKTDRSNS-----------SP 129

  Fly   138 VSAKSQKLLRS----------PRKATRKISRIPFKVLDAPELQDDFYLNLVDWSSQNVLAVGLGS 192
            .|..|..:|.:          |.|..||:.:.|.||||||.||||||||:||||||||||||||:
plant   130 SSPFSPSILGNDNGHSSDSSPPPKPPRKVPKTPHKVLDAPSLQDDFYLNVVDWSSQNVLAVGLGT 194

  Fly   193 CVYLWSACTSQVTRLCDLSPDANTVTSVSWNERGNTVAVGTHHGYVTVWDVAANKQINKLNGHSA 257
            |||||:|..|:||:||||.|: ::|.||.|...|:.:::||.||.|.|||....|::..:.||..
plant   195 CVYLWTASNSKVTKLCDLGPN-DSVCSVQWTREGSYISIGTSHGQVQVWDGTQCKRVRTMGGHQT 258

  Fly   258 RVGALAWNSDILSSGSRDRWIIQRDTRTPQLQSE--RRLAGHRQEVCGLKWSPDNQYLASGGNDN 320
            |.|.|||||.|||||||||.|:|.|.|   :||:  .:|.||:.||||||||.|::.||||||||
plant   259 RTGVLAWNSRILSSGSRDRNILQHDIR---VQSDFVSKLVGHKSEVCGLKWSHDDRELASGGNDN 320

  Fly   321 RLYVWNQHSVNPVQSYTEHMAAVKAIAWSPHHHGLLASGGGTADRCIRFWNTLTGQPMQCVDTGS 385
            :|.|||.||..|:...|||.||||||.||||...||||||||||||||||||..|..:..:||||
plant   321 QLLVWNNHSQQPILKLTEHTAAVKAITWSPHQSSLLASGGGTADRCIRFWNTTNGNQLNSIDTGS 385

  Fly   386 QVCNLAWSKHSSELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLALSPDGEAIVTGAGDE 450
            |||||||||:.:|:|||||||||||::|||||:::||.|||||.||||||.||||:.||||||||
plant   386 QVCNLAWSKNVNEIVSTHGYSQNQIMLWKYPSMSKVATLTGHSMRVLYLATSPDGQTIVTGAGDE 450

  Fly   451 TLRFWNVFSKARSQ 464
            ||||||||...:.|
plant   451 TLRFWNVFPSVKMQ 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr	NP_524852.2	WD40	<174..469	CDD:225201	192/293 (66%)
		WD40	178..456	CDD:238121	184/279 (66%)
		WD40 repeat	217..254	CDD:293791	14/36 (39%)
		WD40 repeat	260..296	CDD:293791	22/37 (59%)
		WD40 repeat	301..337	CDD:293791	23/35 (66%)
		WD40 repeat	344..382	CDD:293791	26/37 (70%)
		WD40 repeat	387..425	CDD:293791	27/37 (73%)
		WD40 repeat	431..457	CDD:293791	22/25 (88%)
FZR3	NP_001190305.1	WD40	<176..462	CDD:225201	191/289 (66%)
		WD40 repeat	178..213	CDD:293791	27/34 (79%)
		WD40	197..456	CDD:238121	168/262 (64%)
		WD40 repeat	218..253	CDD:293791	14/34 (41%)
		WD40 repeat	259..296	CDD:293791	23/39 (59%)
		WD40 repeat	301..337	CDD:293791	23/35 (66%)
		WD40 repeat	344..382	CDD:293791	26/37 (70%)
		WD40 repeat	387..425	CDD:293791	27/37 (73%)
		WD40 repeat	431..457	CDD:293791	22/25 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	131	1.000	Domainoid score	I1676
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9444
Inparanoid	1	1.050	490	1.000	Inparanoid score	I328
OMA	1	1.010	-	-		QHG54440
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	1	1.000	-	-		otm3096
orthoMCL	1	0.900	-	-		OOG6_101383
Panther	1	1.100	-	-	O	PTHR19918
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1507
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840