DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr and CCS52A2

DIOPT Version :9

Sequence 1:	NP_524852.2	Gene:	fzr / 45922	FlyBaseID:	FBgn0262699	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	NP_192929.2	Gene:	CCS52A2 / 826799	AraportID:	AT4G11920	Length:	475	Species:	Arabidopsis thaliana

Alignment Length:	450	Identity:	251/450 - (55%)
Similarity:	315/450 - (70%)	Gaps:	28/450 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 NNFESSTTPTSLDRFIPCRAYNNWQTNFASINKSNDNSPQTSKKQRDCGETARDSLAYSCLLKNE 87
            |::.|.:.|...|||||.|:    .:|||..:.::.:..:...|:...|       :|:.|||..
plant    41 NHYHSPSKPIYSDRFIPSRS----GSNFALFDLASSSPNKKDGKEDGAG-------SYASLLKTA 94

  Fly    88 LLGSAIDDVKTAGEERNE--NAYTPAAKRSLFKYQSPTKQDYNGECPYSLSPVSAKSQKLLRSPR 150
            |.|...       .|:::  |.::|:.  ::|::::.|::..|...|:....||..|.    ||.
plant    95 LFGPVT-------PEKSDVVNGFSPSG--NIFRFKTETQRSLNLYPPFDSDVVSGVSP----SPV 146

  Fly   151 KATRKISRIPFKVLDAPELQDDFYLNLVDWSSQNVLAVGLGSCVYLWSACTSQVTRLCDLSPDAN 215
            |:.|||.|.|:||||||.|||||||||||||:|||||||||:|||||:||:|:||:||||..| .
plant   147 KSPRKILRSPYKVLDAPALQDDFYLNLVDWSAQNVLAVGLGNCVYLWNACSSKVTKLCDLGVD-E 210

  Fly   216 TVTSVSWNERGNTVAVGTHHGYVTVWDVAANKQINKLNGHSARVGALAWNSDILSSGSRDRWIIQ 280
            ||.||.|..||..:|:||..|.|.:|||...|.|..:.||..|||||||:|.:|||||||:.|:|
plant   211 TVCSVGWALRGTHLAIGTSSGTVQIWDVLRCKNIRTMEGHRLRVGALAWSSSVLSSGSRDKSILQ 275

  Fly   281 RDTRTPQLQSERRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSVNPVQSYTEHMAAVKA 345
            ||.|| |.....:|.||:.|:||||||.||:.||||||||:|:||||||..||..:.||.|||||
plant   276 RDIRT-QEDHVSKLKGHKSEICGLKWSSDNRELASGGNDNKLFVWNQHSTQPVLRFCEHAAAVKA 339

  Fly   346 IAWSPHHHGLLASGGGTADRCIRFWNTLTGQPMQCVDTGSQVCNLAWSKHSSELVSTHGYSQNQI 410
            |||||||.|||||||||||||||||||.|...:.||||.||||||.|||:.:|||||||||||||
plant   340 IAWSPHHFGLLASGGGTADRCIRFWNTTTNTHLNCVDTNSQVCNLVWSKNVNELVSTHGYSQNQI 404

  Fly   411 LVWKYPSLTQVAKLTGHSYRVLYLALSPDGEAIVTGAGDETLRFWNVFSKARSQKENKSV 470
            :|||||:::::|.||||||||||||:||||:.||||||||||||||||...:||.....:
plant   405 IVWKYPTMSKLATLTGHSYRVLYLAVSPDGQTIVTGAGDETLRFWNVFPSPKSQSRESEI 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr	NP_524852.2	WD40	<174..469	CDD:225201	202/294 (69%)
		WD40	178..456	CDD:238121	192/277 (69%)
		WD40 repeat	217..254	CDD:293791	16/36 (44%)
		WD40 repeat	260..296	CDD:293791	21/35 (60%)
		WD40 repeat	301..337	CDD:293791	25/35 (71%)
		WD40 repeat	344..382	CDD:293791	30/37 (81%)
		WD40 repeat	387..425	CDD:293791	26/37 (70%)
		WD40 repeat	431..457	CDD:293791	22/25 (88%)
CCS52A2	NP_192929.2	WD40	212..451	CDD:392136	164/239 (69%)
		WD40 repeat	212..249	CDD:293791	16/36 (44%)
		WD40 repeat	255..290	CDD:293791	21/35 (60%)
		WD40 repeat	295..331	CDD:293791	25/35 (71%)
		WD40 repeat	338..373	CDD:293791	29/34 (85%)
		WD40 repeat	381..419	CDD:293791	26/37 (70%)
		WD40 repeat	425..451	CDD:293791	22/25 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	131	1.000	Domainoid score	I1676
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	490	1.000	Inparanoid score	I328
OMA	1	1.010	-	-		QHG54440
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	1	1.000	-	-		otm3096
orthoMCL	1	0.900	-	-		OOG6_101383
Panther	1	1.100	-	-	LDO	PTHR19918
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1507
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840