DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzr and FZR1

DIOPT Version :9

Sequence 1:	NP_524852.2	Gene:	fzr / 45922	FlyBaseID:	FBgn0262699	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	XP_016882352.1	Gene:	FZR1 / 51343	HGNCID:	24824	Length:	528	Species:	Homo sapiens

Alignment Length:	495	Identity:	342/495 - (69%)
Similarity:	391/495 - (78%)	Gaps:	23/495 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EYEKRILK-------HYSPVARNLFNNFESSTTPTSL-----DRFIPCRAYNNWQTNFASINKSN 57
            :||:|:|:       :..|....:......:::|.|.     |||||.||..||..||..||: |
Human    36 DYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINE-N 99

  Fly    58 DNSPQTSKKQRDC-GETARDSLAYSCLLKNELLGSAIDDVK-TAGEERNENAYTPAAKRSLFKYQ 120
            :.||..::|.:|. .:..:|.||||.||||||||:.|:.|: ...|:|.....|| .|:.||.|.
Human   100 EKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTP-EKKGLFTYS 163

  Fly   121 SPTKQ----DYNGECPYSLSPVSAKSQKLLRSPRKATRKISRIPFKVLDAPELQDDFYLNLVDWS 181
            ..||:    |.|...||||||||.|||||||||||.|||||:|||||||||||||||||||||||
Human   164 LSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWS 228

  Fly   182 SQNVLAVGLGSCVYLWSACTSQVTRLCDLSPDANTVTSVSWNERGNTVAVGTHHGYVTVWDVAAN 246
            |.|||:||||:|||||||||||||||||||.:.::||||.|:||||.||||||.|:|.:||.||.
Human   229 SLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAG 293

  Fly   247 KQINKLNGHSARVGALAWNSDILSSGSRDRWIIQRDTRTPQLQSERRLAGHRQEVCGLKWSPDNQ 311
            |:::.|.||:|||||||||::.||||||||.|:|||.|||.|||||||.||||||||||||.|:|
Human   294 KKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQ 358

  Fly   312 YLASGGNDNRLYVWNQHSVNPVQSYTEHMAAVKAIAWSPHHHGLLASGGGTADRCIRFWNTLTGQ 376
            .||||||||:|.|||..|::|||.||||:|||||||||||.||||||||||||||||||||||||
Human   359 LLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQ 423

  Fly   377 PMQCVDTGSQVCNLAWSKHSSELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLALSPDGE 441
            |:||:||||||||||||||::||||||||||||||||||||||||||||||||||||||:|||||
Human   424 PLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGE 488

  Fly   442 AIVTGAGDETLRFWNVFSKARSQK---ENKSVLNLFANIR 478
            |||||||||||||||||||.||.|   |:.||||||..||
Human   489 AIVTGAGDETLRFWNVFSKTRSTKVKWESVSVLNLFTRIR 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr	NP_524852.2	WD40	<174..469	CDD:225201	243/297 (82%)
		WD40	178..456	CDD:238121	229/277 (83%)
		WD40 repeat	217..254	CDD:293791	23/36 (64%)
		WD40 repeat	260..296	CDD:293791	28/35 (80%)
		WD40 repeat	301..337	CDD:293791	25/35 (71%)
		WD40 repeat	344..382	CDD:293791	35/37 (95%)
		WD40 repeat	387..425	CDD:293791	35/37 (95%)
		WD40 repeat	431..457	CDD:293791	24/25 (96%)
FZR1	XP_016882352.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159775
Domainoid	1	1.000	217	1.000	Domainoid score	I2686
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9444
Inparanoid	1	1.050	669	1.000	Inparanoid score	I745
Isobase	1	0.950	-	0	Normalized mean entropy	S771
OMA	1	1.010	-	-		QHG54440
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	1	1.000	-	-		oto88681
orthoMCL	1	0.900	-	-		OOG6_101383
Panther	1	1.100	-	-	LDO	PTHR19918
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R711
SonicParanoid	1	1.000	-	-		X1507
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750