DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzr and cdc20

DIOPT Version :9

Sequence 1:	NP_524852.2	Gene:	fzr / 45922	FlyBaseID:	FBgn0262699	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	NP_998245.2	Gene:	cdc20 / 406353	ZFINID:	ZDB-GENE-040426-2044	Length:	496	Species:	Danio rerio

Alignment Length:	454	Identity:	187/454 - (41%)
Similarity:	258/454 - (56%)	Gaps:	57/454 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 NFESSTTPTSL--DRFIPCRAYNNWQTNFASINKSNDNSPQTSKKQRDCGETARDSLAYSCLLKN 86
            |.::..||:..  ||:||.|  ||.|.:.||...|.:|.|....:.    .||.:..|:|..|.
Zfish    66 NGKTQNTPSKAGGDRYIPTR--NNKQLDVASFLISKENEPVEESEP----STAPNQKAWSMSLN- 123

  Fly    87 ELLGSAIDDVK---TAGEERNENAYTPAAKRSLFKYQSPTKQDYNGECPYSLSPVSAKSQKLLRS 148
               |..|::.|   ..|:.    .|.|..      ||:..|..|: :.|   :|||.|.
Zfish   124 ---GYDIEEAKILHLGGKP----LYAPEG------YQNNLKVLYS-QVP---TPVSVKK------ 165

  Fly   149 PRKATRKISRIPFKVLDAPELQDDFYLNLVDWSSQNVLAVGLGSCVYLWSACTSQVTRLCDLSPD 213
                :|.||..|.::||||::::||||||:||..||||||||.:.||||.|....:..|..:..|
Zfish   166 ----SRYISSYPERILDAPDIRNDFYLNLMDWGRQNVLAVGLANQVYLWDAGEGDIVLLKKMEDD 226

  Fly   214 ANTVTSVSWNERGNTVAVGTHHGYVTVWDVAANKQINKLNGHSARVGALAWNSDILSSGSRDRWI 278
            ...:.||||::.||.:|:||....|.:|||...|::..::|||||||.|:||..|||||||...|
Zfish   227 NEYICSVSWSKDGNFLAIGTSDCKVELWDVQYQKRLRSMDGHSARVGCLSWNDHILSSGSRSGLI 291

  Fly   279 IQRDTRTPQLQSERRL---AGHRQEVCGLKWSPDNQYLASGGNDNRLYVW-------NQHSVNPV 333
            .|.|.|.    ::..:   .||.||||||.||||.:|||||||||.:|:|       ||    .:
Zfish   292 HQHDVRV----ADHHIFTFGGHTQEVCGLTWSPDGRYLASGGNDNMVYIWPMTTGSENQ----AI 348

  Fly   334 QSYTEHMAAVKAIAWSPHHHGLLASGGGTADRCIRFWNTLTGQPMQCVDTGSQVCNLAWSKHSSE 398
            .:.:||..||||:||.|....:|||||||:||.||.||..:|..:..:||.|||.:|.::.:..|
Zfish   349 HALSEHQGAVKALAWCPWQPNILASGGGTSDRHIRIWNASSGSCISSLDTCSQVSSLVFAPNYKE 413

  Fly   399 LVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLALSPDGEAIVTGAGDETLRFWNVFSKAR 462
            |||.||::.:::::|||||..:|.:..||..|:|.|||||||..:.:.|.|||:|.|..|.|.:
Zfish   414 LVSGHGFAHDKVVIWKYPSFAKVTEHEGHEARILNLALSPDGSTLASIAADETIRLWKCFEKEK 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr	NP_524852.2	WD40	<174..469	CDD:225201	141/299 (47%)
		WD40	178..456	CDD:238121	134/287 (47%)
		WD40 repeat	217..254	CDD:293791	14/36 (39%)
		WD40 repeat	260..296	CDD:293791	15/38 (39%)
		WD40 repeat	301..337	CDD:293791	21/42 (50%)
		WD40 repeat	344..382	CDD:293791	19/37 (51%)
		WD40 repeat	387..425	CDD:293791	14/37 (38%)
		WD40 repeat	431..457	CDD:293791	14/25 (56%)
cdc20	NP_998245.2	WD40	<194..484	CDD:225201	135/292 (46%)
		WD40	196..471	CDD:238121	132/282 (47%)
		WD40 repeat	230..267	CDD:293791	14/36 (39%)
		WD40 repeat	273..308	CDD:293791	15/38 (39%)
		WD40 repeat	313..352	CDD:293791	21/42 (50%)
		WD40 repeat	359..397	CDD:293791	19/37 (51%)
		WD40 repeat	402..440	CDD:293791	14/37 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54440
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.930