DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr and cdc20

DIOPT Version :9

Sequence 1:	NP_524852.2	Gene:	fzr / 45922	FlyBaseID:	FBgn0262699	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	NP_988945.1	Gene:	cdc20 / 394542	XenbaseID:	XB-GENE-970663	Length:	507	Species:	Xenopus tropicalis

Alignment Length:	480	Identity:	195/480 - (40%)
Similarity:	263/480 - (54%)	Gaps:	82/480 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SSTTPTSL-----------------DRFIPCRAYNNWQTNFASI-----NKSNDNSPQTSKKQRD 69
            ||.||:..                 |||||.|  :..|.:.||.     |:..|.||...::|:
Frog    61 SSKTPSKTPGKSGPKMQGTPSRAGGDRFIPNR--SAMQMDVASFLLCKENEPADTSPTKKEQQK- 122

  Fly    70 CGETARDSLAYSCLLKNELLGSAIDDVK---TAGEERNENAYTPAAKRSLFKYQSPTKQDYNGEC 131
                     |::.    .|.|..:::.|   ..|..:|    .|..      ||:..|..|
Frog   123 ---------AWAM----NLNGFDMEEAKILRLGGRPQN----APEG------YQNNLKVLY---- 160

  Fly   132 PYSLSPVSAKSQKLL-RSPRKATRKISRIPFKVLDAPELQDDFYLNLVDWSSQNVLAVGLGSCVY 195
                      |||.. .|.:|..|.|..:|.:|||||::::|:||||:||||||.|||.|...||
Frog   161 ----------SQKTTPGSSKKTGRYIPSMPDRVLDAPDIRNDYYLNLIDWSSQNFLAVALNDSVY 215

  Fly   196 LWSACTSQVTRLCDLSPDANTVTSVSWNERGNTVAVGTHHGYVTVWDVAANKQINKLNGHSARVG 260
            ||:..|..:..|..:......::||||.:.||.:||||.:..|.:|||...|::..:..||:|||
Frog   216 LWNYATGDIILLLQMEHSEEYISSVSWIKEGNYLAVGTSNSEVQLWDVQQQKRLRNMTSHSSRVG 280

  Fly   261 ALAWNSDILSSGSRDRWIIQRDTRTPQLQSERRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVW 325
            ||:||:.|||||||...|...|.|..| .....|.||.|||||||||||.:|||||.|||.:.||
Frog   281 ALSWNNHILSSGSRTGHIHHHDVRVAQ-HHVSTLTGHTQEVCGLKWSPDGRYLASGANDNLVNVW 344

  Fly   326 -----NQHSVNPVQSYTEHMAAVKAIAWSPHHHGLLASGGGTADRCIRFWNTLTGQPMQCVDTGS 385
                 :....:|||::|:|..||||:||.|....:||:||||:||.||.||..:|..:..|||.|
Frog   345 PCVQGDSGEFSPVQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGTCLNSVDTHS 409

  Fly   386 QVCNLAWSKHSSELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLALSPDGEAIVTGAGDE 450
            |||::.||.:..||:|.||::|||:::||||::|:|.:|.||:.|||.||:||||..:.:.|.||
Frog   410 QVCSILWSTNYKELISGHGFAQNQLVLWKYPTMTRVTELKGHTARVLNLAISPDGCTVASAAADE 474

  Fly   451 TLRFWNVF----------SKARSQK 465
            |||.|..|          .||||.|
Frog   475 TLRLWKCFEVDPVTKKEKEKARSSK 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr	NP_524852.2	WD40	<174..469	CDD:225201	152/307 (50%)
		WD40	178..456	CDD:238121	141/282 (50%)
		WD40 repeat	217..254	CDD:293791	15/36 (42%)
		WD40 repeat	260..296	CDD:293791	17/35 (49%)
		WD40 repeat	301..337	CDD:293791	22/40 (55%)
		WD40 repeat	344..382	CDD:293791	18/37 (49%)
		WD40 repeat	387..425	CDD:293791	18/37 (49%)
		WD40 repeat	431..457	CDD:293791	15/25 (60%)
cdc20	NP_988945.1	WD40	198..480	CDD:238121	141/282 (50%)
		WD40 repeat	237..272	CDD:293791	15/34 (44%)
		WD40 repeat	278..315	CDD:293791	19/37 (51%)
		WD40 repeat	320..361	CDD:293791	22/40 (55%)
		WD40 repeat	368..406	CDD:293791	18/37 (49%)
		WD40 repeat	411..449	CDD:293791	18/37 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010