DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzr and Fzr1

DIOPT Version :9

Sequence 1:	NP_524852.2	Gene:	fzr / 45922	FlyBaseID:	FBgn0262699	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	NP_001101544.2	Gene:	Fzr1 / 314642	RGDID:	1308713	Length:	493	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	342/492 - (69%)
Similarity:	389/492 - (79%)	Gaps:	20/492 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EYEKRILK-------HYSPVARNLFNNFESSTTPTSL-----DRFIPCRAYNNWQTNFASINKSN 57
            :||:|:|:       :..|....:......:.:|.|.     |||||.||..||..||..||: |
  Rat     4 DYERRLLRQIIIQNENTVPCVSEMRRTLTPANSPVSSPSKHGDRFIPSRAGANWSVNFHRINE-N 67

  Fly    58 DNSPQTSKKQRDC-GETARDSLAYSCLLKNELLGSAIDDVK-TAGEERNENAYTPAAKRSLFKYQ 120
            :.||..::|.:|. .:..:|.||||.||||||||:.|:.|: ...|:|.....||..| .||.|.
  Rat    68 EKSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEHK-GLFTYS 131

  Fly   121 SPTKQ----DYNGECPYSLSPVSAKSQKLLRSPRKATRKISRIPFKVLDAPELQDDFYLNLVDWS 181
            ..:|:    |.|...||||||||.|||||||||||.|||||:|||||||||||||||||||||||
  Rat   132 LSSKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYLNLVDWS 196

  Fly   182 SQNVLAVGLGSCVYLWSACTSQVTRLCDLSPDANTVTSVSWNERGNTVAVGTHHGYVTVWDVAAN 246
            |.|||:||||:|||||||||||||||||||.:.::||||.|:||||.||||||.|:|.:||.||.
  Rat   197 SLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAG 261

  Fly   247 KQINKLNGHSARVGALAWNSDILSSGSRDRWIIQRDTRTPQLQSERRLAGHRQEVCGLKWSPDNQ 311
            |:::.|.||:|||||||||:|.||||||||.|:|||.|||.|||||||.||||||||||||.|:|
  Rat   262 KKLSVLEGHTARVGALAWNADQLSSGSRDRMILQRDIRTPALQSERRLQGHRQEVCGLKWSTDHQ 326

  Fly   312 YLASGGNDNRLYVWNQHSVNPVQSYTEHMAAVKAIAWSPHHHGLLASGGGTADRCIRFWNTLTGQ 376
            .||||||||:|.|||..|::|||.||||:|||||||||||.||||||||||||||||||||||||
  Rat   327 LLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQ 391

  Fly   377 PMQCVDTGSQVCNLAWSKHSSELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLALSPDGE 441
            |:||:||||||||||||||::||||||||||||||||||||||||||||||||||||||:|||||
  Rat   392 PLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLAMSPDGE 456

  Fly   442 AIVTGAGDETLRFWNVFSKARSQKENKSVLNLFANIR 478
            |||||||||||||||||||.||.||:.||||||..||
  Rat   457 AIVTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr	NP_524852.2	WD40	<174..469	CDD:225201	244/294 (83%)
		WD40	178..456	CDD:238121	230/277 (83%)
		WD40 repeat	217..254	CDD:293791	23/36 (64%)
		WD40 repeat	260..296	CDD:293791	29/35 (83%)
		WD40 repeat	301..337	CDD:293791	25/35 (71%)
		WD40 repeat	344..382	CDD:293791	35/37 (95%)
		WD40 repeat	387..425	CDD:293791	35/37 (95%)
		WD40 repeat	431..457	CDD:293791	24/25 (96%)
Fzr1	NP_001101544.2	WD40	193..471	CDD:238121	230/277 (83%)
		WD40 repeat	232..269	CDD:293791	23/36 (64%)
		WD40 repeat	275..311	CDD:293791	29/35 (83%)
		WD40 repeat	316..352	CDD:293791	25/35 (71%)
		WD40 repeat	359..397	CDD:293791	35/37 (95%)
		WD40 repeat	402..440	CDD:293791	35/37 (95%)
		WD40 repeat	446..487	CDD:293791	35/40 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353839
Domainoid	1	1.000	214	1.000	Domainoid score	I2659
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9444
Inparanoid	1	1.050	671	1.000	Inparanoid score	I703
OMA	1	1.010	-	-		QHG54440
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	1	1.000	-	-		oto95812
orthoMCL	1	0.900	-	-		OOG6_101383
Panther	1	1.100	-	-	LDO	PTHR19918
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1507
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770