Protein Alignment fzr and fzy-1

DIOPT Version :9

• Sequence 1: NP_524852.2
• Gene: fzr / 45922
• FlyBaseID: FBgn0262699
• Length: 478
• Species: Drosophila melanogaster
• Sequence 2: NP_495051.1
• Gene: fzy-1 / 266859
• WormBaseID: WBGene00001511
• Length: 507
• Species: Caenorhabditis elegans
• Alignment Length: 488
• Identity: 115/488 - (23%)
• Similarity: 217/488 - (44%)
• Gaps: 72/488 - (14%)

  Fly    35 DRFIPCRA-------YNNWQTNFASINKSNDNS----PQTSKKQRDCGETARDSLAYSCLLKNEL 88
            |||:..|.       .|:..|:....||.|.|:    |.:.:|:...||..:.      :::::.
 Worm    48 DRFLGVRLDQDELDHANHLMTSKLYSNKENLNNSMSEPNSPEKKSVEGEALKQ------MMRHKS 106

  Fly    89 LGSAIDDVKTAGEE---RNENAYTPAAKRSLFKYQSPTKQDYNGECPYSLSPVSAKSQKLLRSPR 150
            .|:..|  ...|:.   ..:|...|.|    ..|.:..|..|:...  .::|.|        |.:
 Worm   107 TGALTD--ADDGDRILCYKKNLAPPPA----IGYINQAKVLYSTNS--VINPAS--------SVK 155

  Fly   151 KATRKISRIPFKVLDAPELQDDFYLNLVDWSSQNVLAVGLGSCVYLWSACTSQVTRLCDLSPDAN 215
            |:||.:.....||||.|.|..|.|...:||...|.:||.||..:|||:..|..:..|.:.:...|
 Worm   156 KSTRHVKETATKVLDGPGLTKDLYSRHLDWGCHNWVAVALGHELYLWNTETCVIKNLFEDNAPTN 220

  Fly   216 --TVTSVSWNERGNTVAVGTHHGYVTVWDVAANK------QINKLN-GHSARVGALAWNSD-ILS 270
              .:|||.|::.|..:::|...|.|.::|....|      ::..|. |.::|..::||... :::
 Worm   221 EGLITSVRWSQEGRYISLGYASGAVKIYDPNRPKTTEYVRELRTLRVGGASRCASIAWRKQGVMT 285

  Fly   271 SGSRDRWIIQRDTRTPQ--LQSERRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSV--- 330
            .|.:...|:..|.|..|  :.|.....||.::|..|:||.|.....||.:|....:|:...|
 Worm   286 CGYKSGDIVNHDVRISQHVVSSWGGDNGHCRDVTALEWSADENMCVSGSSDRTAKIWDGRHVRGS 350

  Fly   331 ------NPVQSYTEHMAAVKAIAWSPHHHGLLASGGGTADRCIRFWNTLTG----QPMQCVDTGS 385
                  .|:.:..||...|:...:.....|:||:|||..|..::.|:....    :.:...:||.
 Worm   351 TVIQDPEPMFTIDEHTGQVRTAQFCSFRDGILATGGGINDGTVKLWDVKRQFQKVRELNVCETGG 415

  Fly   386 QVCNLAWSKHSSELV--STHGYSQNQILVWKYPSLTQVA-KLTGHSYRVLYLALSPDGEAIVTGA 447
             |..:.:::..||::  |..|:    :.::::.:..::: ::...:..::.|..||..|.:: |.
 Worm   416 -VGGIVFNRPYSEMLTASDDGF----LRIYRFNANYKLSHEIQASNEPIMDLVGSPFDEVLI-GD 474

  Fly   448 GDETLRFWNVFS--KARSQKENKSVLNLFANIR 478
            .:|||:.:.:|:  |:.:..:..:..|:..|:|
 Worm   475 MEETLKVFQLFNVDKSTNILDRTAPKNVGLNVR 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fzr	NP_524852.2	WD40	<174..469	CDD:225201	76/324 (23%)
		WD40	178..456	CDD:238121	73/305 (24%)
		WD40 repeat	217..254	CDD:293791	11/43 (26%)
		WD40 repeat	260..296	CDD:293791	8/38 (21%)
		WD40 repeat	301..337	CDD:293791	11/44 (25%)
		WD40 repeat	344..382	CDD:293791	8/41 (20%)
		WD40 repeat	387..425	CDD:293791	5/40 (13%)
		WD40 repeat	431..457	CDD:293791	8/25 (32%)
fzy-1	NP_495051.1	WD40	<197..490	CDD:225201	67/298 (22%)
		WD40	221..484	CDD:295369	60/268 (22%)
		WD40 repeat	225..268	CDD:293791	11/42 (26%)
		WD40 repeat	273..312	CDD:293791	8/38 (21%)
		WD40 repeat	319..363	CDD:293791	10/43 (23%)
		WD40 repeat	369..409	CDD:293791	9/39 (23%)
		WD40 repeat	416..452	CDD:293791	5/39 (13%)
		WD40 repeat	459..482	CDD:293791	8/23 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S771
OMA	1	1.010	-	-		QHG54440
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.770