DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr and slp1

DIOPT Version :9

Sequence 1:	NP_524852.2	Gene:	fzr / 45922	FlyBaseID:	FBgn0262699	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	NP_593161.1	Gene:	slp1 / 2543222	PomBaseID:	SPAC821.08c	Length:	488	Species:	Schizosaccharomyces pombe

Alignment Length:	426	Identity:	166/426 - (38%)
Similarity:	228/426 - (53%)	Gaps:	49/426 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DRFIPCRAYNNWQTNFASINKSNDNSPQTSKKQRDCGETARDSLAYSCLLKNELLGSAIDDVKTA 99
            |||||.|.    .|..|.:|..:.:.|      .|..|:..::..:.  |...:|...:|
pombe    88 DRFIPSRP----NTANAFVNSISSDVP------FDYSESVAEACGFD--LNTRVLAFKLD----- 135

  Fly   100 GEERNENAYTPAAKRSLFKYQSPTKQDYNGECPYSLSPVSAKSQKLLRSPRKATRKISRIPFKVL 164
                     .|.||:                 |..|.....:.|:.:.:|.|  |:.:..|.:||
pombe   136 ---------APEAKK-----------------PVDLRTQHNRPQRPVVTPAK--RRFNTTPERVL 172

  Fly   165 DAPELQDDFYLNLVDWSSQNVLAVGLGSCVYLWSACTSQVTRLCDLSPDANTVTSVSWNERGNTV 229
            |||.:.||:||||:|||:.||:||.|...||:|:|.:..|:.|.: :.::..|.||.|:..|:.:
pombe   173 DAPGIIDDYYLNLLDWSNLNVVAVALERNVYVWNADSGSVSALAE-TDESTYVASVKWSHDGSFL 236

  Fly   230 AVGTHHGYVTVWDVAANKQINKLNGHSARVGALAWNSDILSSGSRDRWIIQRDTRTPQLQSERRL 294
            :||..:|.|.::||.:..::..:.||.||||.|:||..:||||||...|...|.|....|. ..|
pombe   237 SVGLGNGLVDIYDVESQTKLRTMAGHQARVGCLSWNRHVLSSGSRSGAIHHHDVRIANHQI-GTL 300

  Fly   295 AGHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSVNPVQSYTEHMAAVKAIAWSPHHHGLLASG 359
            .||..|||||.|..|...||||||||.:.:|:..|..|..:.|.|.|||||:||.|....|||:|
pombe   301 QGHSSEVCGLAWRSDGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATG 365

  Fly   360 GGTADRCIRFWNTLTGQPMQCVDTGSQVCNLAWSKHSSELVSTHGYSQNQILVWKYPS--LTQVA 422
            |||.|:.|.|||..||..:..||.||||.:|.||.||.|::||||:..|.:.:|.|.|  ||:..
pombe   366 GGTMDKQIHFWNAATGARVNTVDAGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQV 430

  Fly   423 KLTGHSYRVLYLALSPDGEAIVTGAGDETLRFWNVF 458
            .:..|..||||.||||||..:.|.|.||.|:||.|:
pombe   431 DIPAHDTRVLYSALSPDGRILSTAASDENLKFWRVY 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr	NP_524852.2	WD40	<174..469	CDD:225201	134/287 (47%)
		WD40	178..456	CDD:238121	128/279 (46%)
		WD40 repeat	217..254	CDD:293791	11/36 (31%)
		WD40 repeat	260..296	CDD:293791	15/35 (43%)
		WD40 repeat	301..337	CDD:293791	17/35 (49%)
		WD40 repeat	344..382	CDD:293791	19/37 (51%)
		WD40 repeat	387..425	CDD:293791	17/39 (44%)
		WD40 repeat	431..457	CDD:293791	16/25 (64%)
slp1	NP_593161.1	WD40	<164..487	CDD:225201	142/305 (47%)
		WD40	202..464	CDD:295369	120/263 (46%)
		WD40 repeat	225..261	CDD:293791	10/35 (29%)
		WD40 repeat	266..301	CDD:293791	15/35 (43%)
		WD40 repeat	309..343	CDD:293791	15/33 (45%)
		WD40 repeat	349..388	CDD:293791	20/38 (53%)
		WD40 repeat	393..433	CDD:293791	17/39 (44%)
		WD40 repeat	439..463	CDD:293791	14/23 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	73	1.000	Domainoid score	I2548
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54440
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820