DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzr and mfr1

DIOPT Version :9

Sequence 1:	NP_524852.2	Gene:	fzr / 45922	FlyBaseID:	FBgn0262699	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	NP_595081.1	Gene:	mfr1 / 2540043	PomBaseID:	SPBC1198.12	Length:	421	Species:	Schizosaccharomyces pombe

Alignment Length:	440	Identity:	208/440 - (47%)
Similarity:	278/440 - (63%)	Gaps:	25/440 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DRFIPCR-AYNNWQTNFASINKSNDNSPQTSKKQRDCGETARDSLAYSCLLKNELLGSAIDDVKT 98
            |||||.| ..|.:..:|.|. |....|..::.:::..|...|..:.   ||..||.||.
pombe     3 DRFIPIRNVSNEFNFSFQSF-KECVLSHGSNLRRKTSGTIQRQFME---LLSMELFGSQ------ 57

  Fly    99 AGEERNENAYTPAAKRSLFK--YQSPTKQDYNGECPYSLSPVSAKSQKLLRSPRKATRKISRIPF 161
              ..|:...|....||.:.|  ..:|.::.      |||||:|.:||.:||.|:|..|...:.|:
pombe    58 --ASRSRAFYYGEDKRKIEKKMLDTPDRKS------YSLSPISPQSQDMLRQPQKPKRAFPKTPY 114

  Fly   162 KVLDAPELQDDFYLNLVDWSSQNVLAVGLGSCVYLWSACTSQVTRLCDLSPDANTVTSVSWNERG 226
            |:||||.|::||||||:||...|||||||.|.:|||||.:.:|.:|.|... .|.||||.|..:|
pombe   115 KILDAPYLKNDFYLNLLDWGQSNVLAVGLASSIYLWSAASGKVVQLHDFGA-TNHVTSVLWTGKG 178

  Fly   227 NTVAVGTHHGYVTVWDVAANKQINKLNGHSARVGALAWNSDILSSGSRDRWIIQRDTRTPQLQSE 291
            ..:||||..|.:.:||:.:.|.:..|.|||.||.|||||.:.|:||.:|..|:..|.|.|...:|
pombe   179 TQLAVGTDSGVIYIWDIESTKSVRSLKGHSERVAALAWNDNTLTSGGKDEVILHHDLRAPGCCAE 243

  Fly   292 RRLAGHRQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSVNPVQSYTEHMAAVKAIAWSPHHHGLL 356
             .:..|.||:|||:|......||||||||.|:||:..|..|:..:.||.||||||.||||..|:|
pombe   244 -MMKVHEQEICGLQWDRSLGQLASGGNDNNLFVWDYRSSRPLHKFEEHTAAVKAIGWSPHQRGIL 307

  Fly   357 ASGGGTADRCIRFWNTLTGQPMQCVDTGSQVCNLAWSKHSSELVSTHGYSQNQILVWKYPSLTQV 421
            ||||||.|||:...|||||:....:||||||||:||||.|:|:|:|||:::||:.:||||||..:
pombe   308 ASGGGTIDRCLTIHNTLTGRLQNKLDTGSQVCNMAWSKTSNEIVTTHGFAKNQVSLWKYPSLKNI 372

  Fly   422 AKLTGHSYRVLYLALSPDGEAIVTGAGDETLRFWNVFSKARSQKENKSVL 471
            |.||.|:.|||||::||||::|||||||||||||.:|:|  ..||..:::
pombe   373 ANLTAHTNRVLYLSMSPDGQSIVTGAGDETLRFWKLFNK--KPKEESTLI 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr	NP_524852.2	WD40	<174..469	CDD:225201	161/294 (55%)
		WD40	178..456	CDD:238121	152/277 (55%)
		WD40 repeat	217..254	CDD:293791	15/36 (42%)
		WD40 repeat	260..296	CDD:293791	14/35 (40%)
		WD40 repeat	301..337	CDD:293791	17/35 (49%)
		WD40 repeat	344..382	CDD:293791	23/37 (62%)
		WD40 repeat	387..425	CDD:293791	22/37 (59%)
		WD40 repeat	431..457	CDD:293791	21/25 (84%)
mfr1	NP_595081.1	WD40	<134..414	CDD:225201	153/283 (54%)
		WD40	135..407	CDD:295369	150/273 (55%)
		WD40 repeat	169..206	CDD:293791	15/36 (42%)
		WD40 repeat	212..247	CDD:293791	14/35 (40%)
		WD40 repeat	252..288	CDD:293791	17/35 (49%)
		WD40 repeat	295..333	CDD:293791	23/37 (62%)
		WD40 repeat	338..376	CDD:293791	22/37 (59%)
		WD40 repeat	382..408	CDD:293791	21/25 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I1832
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	394	1.000	Inparanoid score	I397
OMA	1	1.010	-	-		QHG54440
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	1	1.000	-	-		mtm9276
orthoMCL	1	0.900	-	-		OOG6_101383
Panther	1	1.100	-	-	O	PTHR19918
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R711
SonicParanoid	1	1.000	-	-		X1507
TreeFam	1	0.960	-	-
	12	11.860