Protein Alignment fzr and fzr3

DIOPT Version :10

• Sequence 1: NP_524852.2
• Gene: fzr / 45922
• FlyBaseID: FBgn0262699
• Length: 478
• Species: Drosophila melanogaster
• Sequence 2: NP_588462.1
• Gene: fzr3 / 2539258
• PomBaseID: SPCC1620.04C
• Length: 509
• Species: Schizosaccharomyces pombe
• Alignment Length: 519
• Identity: 133/519 - (25%)
• Similarity: 216/519 - (41%)
• Gaps: 134/519 - (25%)

  Fly     7 EKRILKHYSPVARNLFNNFESSTTPTSLDRFIPCRAYN--------------NWQ---------T 48
            ||:||  |.       :||        ||||||.:|.:              |.|         .
pombe    44 EKKIL--YK-------SNF--------LDRFIPSKANSDAFRIMENAFTEKLNTQESLLPDILNL 91

  Fly    49 NFASINKSNDNSPQTSKK-------QRDCGETARDSLAYSCLLKNELLGSAIDDVKTAGEERNEN 106
            |...:....||..|.:.:       ||.....|..||..                     |..||
pombe    92 NVKGVLHYKDNKKQKTTRLIESTNYQRQTIHGASSSLVI---------------------EVEEN 135

  Fly   107 AYTPAAKRSLFKYQSPTKQDYNGECPYSLSPVSAKSQKLLRSPRKATRKISRIPFKVLDAPELQD 171
            .:....:.||::                                        .|.::||||.|.|
pombe   136 GHLSNMQGSLYE----------------------------------------TPLRILDAPGLLD 160

  Fly   172 DFYLNLVDWSSQNVLAVGLGSCVYLWSACTSQVTRLCDLSPDANTVTSVSWNERGNTVAVGTHHG 236
            |||::.:.||:...|||.|...|||||..:.  ..:.:|||....|:|::::..|..:|:...:|
pombe   161 DFYISPLAWSTNGELAVALAQNVYLWSEISG--PSIMELSPTTYEVSSLAYSSDGGFLAIARVNG 223

  Fly   237 YVTVWD-VAANKQINKLNGHSARVGALAW---NSDILSSGSRDRWIIQRDTRTPQLQSERRLAGH 297
            :|.:|: ...|.:.:....|...:..:||   |..:|..||.....:.|.|::...:.......|
pombe   224 FVEIWNRKTKNNRCDYKFHHDGDISCMAWSPINWTLLVGGSTGNIYVYRRTKSMMRRVHTIKKVH 288

  Fly   298 RQEVCGLKWSPDNQYLASGGNDNRLYVWNQHSVNPVQSYTEHMAAVKAIAWSPHHHGLLASGGGT 362
            :::||||:|:.|....|||||||.:.:::..|:...:.|..|:|||||:|:.|....|||.|.|:
pombe   289 QEQVCGLEWNYDGTQFASGGNDNLVCIFDIDSLENKKFYWIHLAAVKALAFCPWQKSLLAVGTGS 353

  Fly   363 ADRCIRFWNTLTGQPMQCVDTGSQVCNLAWSKHSSELVSTHGYS----QNQILVWKYPSLTQV-- 421
            .|:.|.|::|..|..:..:..|:||.::.||:...|...:.|||    .:.::|:::|.||:|
pombe   354 NDQQIYFYDTFRGHRIHSLFCGAQVTSVIWSRRYKEFCYSLGYSPEGTNSSLIVYRWPQLTKVFD 418

  Fly   422 ---AKLTG-----------HSYRVLYLALSPDGEAIVTGAGDETLRFWNVFSKARSQKENKSVL 471
               |.:.|           |::|........:||.:|....|||::|:.::.....:..|..||
pombe   419 IPSAAIDGWGQDLRTIMAIHTHRKYSNNTWEEGEYVVVANSDETVKFYKIWGNEMQEIHNDRVL 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fzr	NP_524852.2	WD40	<194..457	CDD:441893	84/286 (29%)
		WD40 repeat	217..254	CDD:293791	8/37 (22%)
		WD40 repeat	260..296	CDD:293791	8/38 (21%)
		WD40 repeat	301..337	CDD:293791	14/35 (40%)
		WD40 repeat	344..382	CDD:293791	14/37 (38%)
		WD40 repeat	387..425	CDD:293791	13/46 (28%)
		WD40 repeat	431..457	CDD:293791	7/25 (28%)
fzr3	NP_588462.1	WD40	<163..384	CDD:441893	69/222 (31%)
		WD40 repeat	164..200	CDD:293791	13/37 (35%)
		WD40 repeat	205..242	CDD:293791	7/36 (19%)
		WD40 repeat	247..285	CDD:293791	8/37 (22%)
		WD40 repeat	293..327	CDD:293791	13/33 (39%)
		WD40 repeat	334..365	CDD:293791	14/30 (47%)
		WD40 repeat	443..478	CDD:293791	7/34 (21%)