Protein Alignment fzr and CDC20B

DIOPT Version :10

• Sequence 1: NP_524852.2
• Gene: fzr / 45922
• FlyBaseID: FBgn0262699
• Length: 478
• Species: Drosophila melanogaster
• Sequence 2: NP_001163873.1
• Gene: CDC20B / 166979
• HGNCID: 24222
• Length: 519
• Species: Homo sapiens
• Alignment Length: 484
• Identity: 154/484 - (31%)
• Similarity: 231/484 - (47%)
• Gaps: 83/484 - (17%)

  Fly    43 YNNWQTNFA---SINKSNDNSPQTSK-KQRDCGETARDSLA--YSCLLKNELLGSAIDDVKTAGE 101
            |:::::|||   |......:||.|:: :|......:.||..  .|.....|..||.:   ||..|
Human    51 YSDFKSNFAKRLSAEVPVASSPITTRWQQSQTRALSSDSFGEEQSTTYLPEASGSVL---KTPPE 112

  Fly   102 E-------RNENAYTPA------AKRSLFKYQSPTKQDYNGECPYSLSPVSAKSQKLLRS----- 148
            :       |.|...||:      :..:|...::|...|.:.:     ..|::|.||.|:.
Human   113 KETLTLGSRKEQLKTPSKGISETSNSALHFCKAPHAMDRDWK-----ESVASKGQKCLKQLFVTQ 172

  Fly   149 --PRKATRKI-----SRIPFK-----VLD----------------APE-------LQDDFYLNLV 178
              .::|..|:     |...:|     |.|                .||       |::|:|||::
Human   173 NVVQQANGKMQLCEQSECVWKGCKDGVRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNIL 237

  Fly   179 DWSSQNVLAVGLGSCVYLWSACTSQVTRLCDLSPDANTVTSVSWNERGNTVAVGTHHGYVTVWDV 243
            |||.||::|:.|||.||:|:..........|||...|.::||||.:.|..:||||..|.|.:|||
Human   238 DWSFQNLVAIALGSAVYIWNGENHNGIENIDLSLTCNYISSVSWIKEGTCLAVGTSEGEVQLWDV 302

  Fly   244 AANKQINKLNGHSARVGALAWNSDILSSGSRDRWIIQRDTRTPQLQSERRLAG---HRQEVCGLK 305
            ...|::..:.||.:.||||:||..|||||||...:...|.|..|     ...|   |:|.||.||
Human   303 VTKKRLRNMLGHLSVVGALSWNHFILSSGSRLGRVYHHDVRVAQ-----HHVGTLRHKQAVCALK 362

  Fly   306 WSPDNQYLASGGNDNRLYVWNQHSV------NPVQSYTEHMAAVKAIAWSPHHHGLLASGGGTAD 364
            ||||.:.|:||.:|..|.:| .|..      .|::..|: ..||||:.|.|...|:||.|||..|
Human   363 WSPDGRLLSSGCSDGLLTIW-PHDPGASAQGQPLKVITQ-STAVKAMDWCPWQSGVLAIGGGMKD 425

  Fly   365 RCIRFWNTLTGQPMQCVDTGSQVCNLAWSKHSSELVSTHGYSQNQILVWKYPSLTQVAKLTGHSY 429
            ..:...:...|:.:|...|.||:|:|.|...:.|:.:..|..:|.:.||..|::::.....||..
Human   426 GRLHILDINAGKSIQTPSTNSQICSLIWLPKTKEIATGQGTPKNDVTVWTCPTVSRSGGFFGHRG 490

  Fly   430 RVLYLALSPDGEAIVTGAGDETLRFWNVF 458
            |||:|:||||...:.:.|.|.|...||.:
Human   491 RVLHLSLSPDQTRVFSAAADGTASVWNCY 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fzr	NP_524852.2	WD40	<194..457	CDD:441893	101/271 (37%)
		WD40 repeat	217..254	CDD:293791	15/36 (42%)
		WD40 repeat	260..296	CDD:293791	15/35 (43%)
		WD40 repeat	301..337	CDD:293791	16/41 (39%)
		WD40 repeat	344..382	CDD:293791	13/37 (35%)
		WD40 repeat	387..425	CDD:293791	9/37 (24%)
		WD40 repeat	431..457	CDD:293791	11/25 (44%)
CDC20B	NP_001163873.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	79..133		14/56 (25%)
		WD 1	229..266		16/36 (44%)
		WD40 repeat	235..271	CDD:293791	15/35 (43%)
		WD 2	271..310		16/38 (42%)
		WD40	<274..517	CDD:441893	94/249 (38%)
		WD40 repeat	276..313	CDD:293791	15/36 (42%)
		WD 3	311..341		15/29 (52%)
		WD40 repeat	319..350	CDD:293791	15/35 (43%)
		WD 4	353..392		17/39 (44%)
		WD40 repeat	358..399	CDD:293791	16/41 (39%)
		WD 5	399..441		15/42 (36%)
		WD40 repeat	405..443	CDD:293791	13/37 (35%)
		WD 6	443..484		12/40 (30%)
		WD40 repeat	448..486	CDD:293791	9/37 (24%)
		WD 7	487..519		15/31 (48%)